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  • Institute of Physics Publishing (IOP)  (11)
  • Oxford University Press  (11)
  • American Institute of Physics (AIP)  (6)
  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 70 (1991), S. 4649-4651 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Waveguides which are single mode at a wavelength of 1.32 μm, and which have linear electro-optic properties, have been fabricated by spin coating polymers onto etched indium phosphide. The side-chain polymer, which comprises the core of the waveguide, develops linear electro-optic properties following an electric field alignment process. A phase modulator has been fabricated by this method and was found to have a switching voltage of 30 V, for a π phase change. The total insertion loss of the device was measured between single-mode lensed fibers to be 9.4 dB. The electro-optic coefficient of the core polymer was calculated from the switching voltage using the geometry of the device and found to range from 6 to 11×10−12 m/V.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 4644-4648 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Kinetics of structure formation in electrorheological (ER) suspensions are characterized by the time required to form percolating fibers following application of an external electric field. Experimental results are compared with predictions from simulations using an electrostatic polarization model for ER suspensions. Results from the two approaches agree, with large response times at small concentrations, decreasing to 10 ms at large concentrations and field strengths of 2 kV/mm.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Neutron scattering measurements of the critical fluctuations associated with the spin-density-wave transition at the Néel temperature, TN≈312 K, in a single-Q chromium crystal are reported. Critical fluctuations are observed emanating from allowed magnetic satellite positions and from satellite positions, corresponding to absent magnetic domains, at which no elastic scattering occurs. The inelastic scattering from these "silent satellites'' grows rapidly with increasing temperature, becoming equal to the allowed single-Q satellite scattering at TN. The line shapes of the inelastic scattering at both the allowed and silent satellites are found to be intrinsically asymmetric, reflecting the underlying nesting geometry of the Fermi surface. Energy scans at the silent satellite positions reveal a weakly temperature dependent, characteristic energy below which the observed scattering intensity falls rapidly to zero. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 2749-2751 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We describe an interdigital linear electro-optic modulator produced from a novel polymer. The polymer was formed into a thin phase grating by simultaneous application of heat and a periodic electric field. The first maximum generated by diffraction of 633-nm HeNe laser light passing through the grating was electrically modulated to a depth of over 17%. The performance of the modulator is compared with a quadratic electro-optic modulator having the same electrode structure but where the polymer was replaced by nitrobenzene. It is estimated that the application of a thermopoling field strength of 20 V/μm to the polymer would impart a linear electro-optic coefficient of about 30 pm/V, which is comparable to the largest coefficient of lithium niobate.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 34 (1993), S. 4692-4703 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Nonclassical symmetry solutions of physically relevant partial differential equations are considered via the reduction methods of Bluman and Cole and Clarkson and Kruskal. Consistency conditions will be provided to show that, if satisfied, these two methods are equivalent in the sense that they lead to the same symmetry solutions. The Boussinesq equation and Burgers' equation are used as illustrative examples. Exact solutions, one of which is new, will be presented for Burgers' equation obtained from the Bluman and Cole method, yet not obtainable by Clarkson and Kruskal's method.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 3987-3989 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have used multilayer mirror optimization methods to enhance the coupling of pump light into vertical-cavity surface-emitting lasers (VCSELs). With previously reported devices, pump light was coupled into VCSEL cavities through interference notches in the mirror reflectance spectrum. This approach is sensitive to temperature dependent reflectance spectrum shifts. We have created devices with a wide pump-band window of low reflectance. We report the simulation, growth, and optically pumped lasing of such optimized low-ripple VCSELs. Further, broadband pump windows open the possibility of spectrally-broad optical pumps and they eliminate need for costly tunable pump lasers. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2013-06-23
    Description: Membrane proteins are estimated to be the targets of 50% of drugs that are currently in development, yet we have few membrane protein crystal structures. As a result, for a membrane protein of interest, the much-needed structural information usually comes from a homology model. Current homology modelling software is optimized for globular proteins, and ignores the constraints that the membrane is known to place on protein structure. Our Memoir server produces homology models using alignment and coordinate generation software that has been designed specifically for transmembrane proteins. Memoir is easy to use, with the only inputs being a structural template and the sequence that is to be modelled. We provide a video tutorial and a guide to assessing model quality. Supporting data aid manual refinement of the models. These data include a set of alternative conformations for each modelled loop, and a multiple sequence alignment that incorporates the query and template. Memoir works with both α-helical and β-barrel types of membrane proteins and is freely available at http://opig.stats.ox.ac.uk/webapps/memoir .
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 8
    Publication Date: 2013-04-24
    Description: Time for primary review: 15 days Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where they are translocated into the lysosomal lumen and degraded via the lysosome-associated membrane protein type 2A (LAMP-2A). Mutations in LAMP2 that inhibit autophagy result in Danon disease characterized by hypertrophic cardiomyopathy. The ryanodine receptor type 2 (RyR2) plays a key role in cardiomyocyte excitation–contraction and its dysfunction can lead to cardiac failure. Whether RyR2 is degraded by CMA is unknown. Methods and results To induce CMA, cultured neonatal rat cardiomyocytes were treated with geldanamycin (GA) to promote protein degradation through this pathway. GA increased LAMP-2A levels together with its redistribution and colocalization with Hsc70 in the perinuclear region, changes indicative of CMA activation. The inhibition of lysosomes but not proteasomes prevented the loss of RyR2. The recovery of RyR2 content after incubation with GA by siRNA targeting LAMP-2A suggests that RyR2 is degraded via CMA. In silico analysis also revealed that the RyR2 sequence harbours six KFERQ motifs which are required for the recognition Hsc70 and its degradation via CMA. Our data suggest that presenilins are involved in RyR2 degradation by CMA. Conclusion These findings are consistent with a model in which oxidative damage of the RyR2 targets it for turnover by presenilins and CMA, which could lead to removal of damaged or leaky RyR2 channels.
    Print ISSN: 0008-6363
    Electronic ISSN: 1755-3245
    Topics: Medicine
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  • 9
    Publication Date: 2015-02-26
    Description: The Mysore Parthenon Birth Cohort was established to examine the long-term effects of maternal glucose tolerance and nutritional status on cardiovascular disease risk factors in the offspring. During 1997–98, 830 of 1233 women recruited from the antenatal clinics of the Holdsworth Memorial Hospital (HMH), Mysore, India, underwent an oral glucose tolerance test. Of these, 667 women delivered live babies at HMH. Four babies with major congenital anomalies were excluded, and the remaining 663 were included for further follow-up. The babies had detailed anthropometry at birth and at 6–12-monthly intervals subsequently. Detailed cardiovascular investigations were done at ages 5, 9.5 and 13.5 years in the children, and in the parents at the 5-year and 9.5-year follow-ups. This ongoing study provides extensive data on serial anthropometry and body composition, physiological and biochemical measures, dietary intake, nutritional status, physical activity measures, stress reactivity measures and cognitive function, and socio-demographic parameters for the offspring. Data on anthropometry, cardiovascular risk factors and nutritional status are available for mothers during pregnancy. Anthropometry and risk factor measures are available for both parents at follow-up.
    Print ISSN: 0300-5771
    Electronic ISSN: 1464-3685
    Topics: Medicine
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  • 10
    Publication Date: 2016-03-24
    Description: Using a radio-quiet subsample of the Sloan Digital Sky Survey spectroscopic quasar catalogue, spanning redshifts 0.5–3.5, we derive the mean millimetre and far-infrared quasar spectral energy distributions (SEDs) via a stacking analysis of Atacama Cosmology Telescope and Herschel -Spectral and Photometric Imaging REceiver data. We constrain the form of the far-infrared emission and find 3–4 evidence for the thermal Sunyaev–Zel'dovich (SZ) effect, characteristic of a hot ionized gas component with thermal energy (6.2 ± 1.7) x 10 60  erg. This amount of thermal energy is greater than expected assuming only hot gas in virial equilibrium with the dark matter haloes of (1–5) x 10 12 h –1 M that these systems are expected to occupy, though the highest quasar mass estimates found in the literature could explain a large fraction of this energy. Our measurements are consistent with quasars depositing up to $(14.5 \pm 3.3)\tau _8^{-1}$  per cent of their radiative energy into their circumgalactic environment if their typical period of quasar activity is 8 x 10 8 yr. For high quasar host masses, ~10 13 h –1 M , this percentage will be reduced. Furthermore, the uncertainty on this percentage is only statistical and additional systematic uncertainties enter at the 40 per cent level. The SEDs are dust dominated in all bands and we consider various models for dust emission. While sufficiently complex dust models can obviate the SZ effect, the SZ interpretation remains favoured at the 3–4 level for most models.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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