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  • 1
    Electronic Resource
    Electronic Resource
    Pure malignant immature teratoma of the ovary: the role of chemotherapy and second-look surgery (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fifteen patients with pure malignant immature teratoma of the ovary were treated at the Institut Gustave Roussy over a 17-year period. Chemotherapy was delivered as primary postoperative therapy in 11 patients. Four other patients received chemotherapy as part of their salvage treatment for recurrent disease. A second-look laparotomy was performed in eight patients. Histological findings were: no tumor in three patients, mature teratoma in four patients, and immature grade 1 teratoma in one patient. The latter five patients had persistent radiologic abnormalities at the end of chemotherapy. Twelve patients remain free of disease 24–228 months from initiation of chemotherapy. Two children were delivered from the two patients who attempted pregnancy. All three patients who died of progressive disease had a grade 3 immature teratoma. We conclude that the treatment of pure immature teratoma of the ovary should include primary conservative surgery and cisplatin-based chemotherapy. Second-look surgery is mandatory in patients with persistant radiologic abnormalities at the completion of chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05060432.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intravaginal amputation of the uterine cervix with frozen section examination of the endocervical margin: a review of 414 consecutive patients (1996)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 6 (1996), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report our institutional experience with the accuracy and usefulness of cervical amputations with frozen section evaluation of the endocervical margin in the management of preinvasive squamous epithelial lesions. Four hundred and fourteen consecutive patients, who underwent amputation of the cervix because of a preinvasive epithelial lesion, or discrepancy between cytologic and biopsy findings especially when colposcopic evaluation was unsatisfactory, had frozen section evaluation of the endocervical margin. Medical records were reviewed and pathologic findings were compared with those obtained on paraffin embedded sections. Frozen section analysis of the upper endocervical margin led to the diagnosis of a residual lesion in 90 (21.7%) cases. In 59 (14.2%) of these cases a further excision was performed during the same operative procedure leading to complete resection in 34 (8.2%) cases. In 403 (97.3%) cases the diagnosis based on the frozen section was corroborated by the permanent sections. For the diagnosis of insufficient cervical resection, the sensitivity and specificity of frozen sections were 93.8% and 99.7% respectively. We conclude that frozen section evaluation of the upper endocervical margin at the time of cervical amputation is a reliable procedure that increases the rate of complete resection. The risks associated with additional anesthesia are then reduced, as are inconvenience to the patients and costs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1996.06060452.x
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  • 3
    Electronic Resource
    Electronic Resource
    Particle velocity fluctuations and correlation lengths in dilute sedimenting suspensions (2002)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 14 (2002), S. 2339-2349 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We measure the instantaneous velocity of particles sedimenting in a three-dimensional container at low particulate Reynolds numbers. We aim at characterizing the main specificities of the particle velocity fluctuations. We obtain the local and instantaneous Eulerian velocity field from particle image velocimetry: a thin Yag laser light sheet (about two diameters thick) illuminates the particles from one side of the cell to the other. Our measurements are therefore spatially localized and, together with the squared cross sections of the cells, these are the two main originalities of our instrumentation. Four different cells and three different particle sizes give access to aspect ratios (cell width W over particle radius a) ranging from about 50 up to 800. We confirm the existence of eddy-like structures for the velocity fluctuations. The structure size is found to be almost independent of the volume fraction Φ for 6.25×10−4〈Φ〈5×10−2 for a fixed aspect ratio W/a, in seeming contradiction with the results of Segrè et al. [Phys. Rev. Lett. 79, 2574 (1997)]. The velocity fluctuations' profiles are close to parabolic for the smallest aspect ratios but display a plateau value in the central part of the cell for higher aspect ratios. The unexpected result of our experiments is the large distance of influence of the boundaries: in fact, the plateau values are observed to saturate for aspect ratios larger than a few hundreds for Φ=1×10−2, for example. Moreover, the saturated plateau values scale as φ0.45±0.05, in contrast with the φ1/3 scaling observed in most previous works. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1483302
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  • 4
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    Cohort Profile: The Swiss Childhood Cancer Survivor Study (2013)
    Oxford University Press
    Details
    Publication Date: 2013-01-04
    Print ISSN: 0300-5771
    Electronic ISSN: 1464-3685
    Topics: Medicine
    Published by Oxford University Press
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  • 5
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    Proteome-Scale Antibody Responses and Outcome of Mycobacterium tuberculosis Infection in Nonhuman Primates and in Tuberculosis Patients (2012)
    Oxford University Press
    Details
    Publication Date: 2012-08-09
    Description: Background. Biomarkers of progression from latent Mycobacterium tuberculosis infection to active tuberculosis are needed. We assessed correlations between infection outcome and antibody responses in macaques and humans by high-throughput, proteome-scale serological studies. Methods. Mycobacterium tuberculosis proteome microarrays were probed with serial sera from macaques representing various infection outcomes and with single-point human sera from tuberculosis suspects. Fluorescence intensity data were analyzed by calculating Z scores and associated P values. Temporal changes in macaque antibody responses were analyzed by polynomial regression. Correlations between human responses and sputum bacillary burden were assessed by quantile and hurdle regression. Results. Macaque outcome groups exhibited distinct antibody profiles: early, transient responses in latent infection and stable antibody increase in active and reactivation disease. In humans, antibody levels and reactive protein numbers increased with bacillary burden. Responses to a subset of 10 proteins were more tightly associated with disease state than reactivity to the broader reactive proteome. Conclusions. Integration of macaque and human data reveals dynamic properties of antibody responses in relation to outcome and leads to actionable findings for translational research. These include the potential of antibody responses to detect acute infection and preclinical tuberculosis and to identify serodiagnostic proteins for the spectrum of bacillary burden in tuberculosis.
    Print ISSN: 0022-1899
    Electronic ISSN: 1537-6613
    Topics: Medicine
    Published by Oxford University Press on behalf of The Infectious Diseases Society of America (IDSA).
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  • 6
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    The cell-wall active mannuronan C5-epimerases in the model brown alga Ectocarpus: From gene context to recombinant protein (2016)
    Oxford University Press
    Details
    Publication Date: 2016-10-08
    Description: Mannuronan C5-epimerases (ManC5-Es) catalyze in brown algae the remodeling of alginate, a major cell-wall component which is involved in many biological functions in these organisms. ManC5-Es are present as large multigenic families in brown algae, likely indicating functional specificities and specializations. ManC5-Es control the distribution pattern of (1–4) linked β- d -mannuronic acid (M) and α- l -guluronic acid (G) residues in alginates, giving rise to widely different polysaccharide compositions and sequences, depending on tissue, season, age, or algal species. As such they are also a source of powerful new tools for the biotechnological and enzymatic processing of alginates, to match the growing interest for food hydrocolloids and in biomedical and nanotechnological applications. We report here the first heterologous production of a ManC5-E of brown algal origin that is successfully refolded in an active form. The activity was measured by 1 H NMR and by an indirect enzymatic assay using a known bacterial alginate lyase. The transcript expression as a function of the developmental program of the brown alga Ectocarpus , together with the bioinformatic analyses of the corresponding gene context of this multigenic family, is also presented.
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 7
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    Experimental demonstration of laser imprint reduction using underdense foams (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-04-08
    Description: Reducing the detrimental effect of the Rayleigh-Taylor (RT) instability on the target performance is a critical challenge. In this purpose, the use of targets coated with low density foams is a promising approach to reduce the laser imprint. This article presents results of ablative RT instability growth measurements, performed on the OMEGA laser facility in direct-drive for plastic foils coated with underdense foams. The laser beam smoothing is explained by the parametric instabilities developing in the foam and reducing the laser imprint on the plastic (CH) foil. The initial perturbation pre-imposed by the means of a specific phase plate was shown to be smoothed using different foam characteristics. Numerical simulations of the laser beam smoothing in the foam and of the RT growth are performed with a suite of paraxial electromagnetic and radiation hydrodynamic codes. They confirmed the foam smoothing effect in the experimental conditions.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 8
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    Cohort Profile: The French Childhood Cancer Survivor Study For Leukaemia (LEA Cohort) (2015)
    Oxford University Press
    Details
    Publication Date: 2015-02-26
    Description: The main aim of the Leucémies de l’Enfant et l’Adolescent (LEA) project (Childhood and Adolescent Leukaemia) is to study the determinants (medical, socioeconomic, behavioural and environmental) of medium- and long-term outcomes of patients treated for childhood acute leukaemia (AL). The LEA study began in 2004 and is based on a French multicentric prospective cohort. Included are children treated for AL since January 1980 (incident and prevalent cases), surviving at month 24 for myeloblastic AL and lymphoblastic AL grafted in first complete remission or at month 48 for lymphoblastic AL not grafted in first complete remission. Information is collected during specific medical visits and notably includes the following data: socioeconomic data, AL history, physical late effects (such as fertility, cardiac function and metabolic syndrome) and quality of life. Data are collected every 2 years until the patient is 20 years old and has had a 10-year follow-up duration from diagnosis or last relapse. Thereafter, assessments are planned every 4 years. In active centres in 2013, eligible patients number more than 3000. The cohort has already included 2385 survivors, with rate of exhaustiveness of almost 80%. Data access can be requested from principal coordinators and must be approved by the steering committee.
    Print ISSN: 0300-5771
    Electronic ISSN: 1464-3685
    Topics: Medicine
    Published by Oxford University Press
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