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  • Wiley-Blackwell  (114)
  • Blackwell Publishing Ltd  (42)
  • American Institute of Physics (AIP)  (14)
  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To identify the reasons behind failures to prevent the development of Rhesus (D) haemolytic disease of the newborn.Design Retrospective analysis of the case records of all pregnancies that resulted in the birth of an infant with a positive direct antiglobulin test on the cord red cells born to Rh(D) negative women between 1 April 1985 and 31 March 1990.Setting Obstetric units in the South East Scotland region and the South East Scotland Regional Blood Transfusion Service Antenatal Laboratory.Main outcome measures The causes and clinical consequences of maternal immunisation to the Rhesus (D) antigen.Results Between 1985 and 1990, 80 pregnancies resulted in the birth of an infant sensitised with anti-D on the cord red cells. There were no deaths due to haemolytic disease, but considerable resources were deployed in obstetric and neonatal care for these pregnancies. Sufficient data were available to categorise the cause of maternal immunisation in 70 pregnancies. Seven cases were due to immunisation by pregnancy before 1970. Sixty-three cases could be attributed to failure of the Rhesus programme: 10 cases (16%) were due to failure to implement the programme adequately, the other 53 cases (84%) were due to failure of the current guidelines to provide adequate protection. Late immunisation in an uncomplicated pregnancy was the single commonest identifiable cause.Conclusions It is likely that substantial further reductions in Rhesus (D) immunisation and haemolytic disease of the newborn will require changes in the Rhesus prevention programme. In particular the role of antenatal prophylaxis requires detailed consideration.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 2606-2611 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Multistability of Langmuir monolayers, in particular those composed of fatty acids, is reflected by a very rich and complicated phase diagram. We argue that strain-tilt-backbone coupling determines the behavior described by that diagram. Following the solid state approach, we show that a natural order parameter set is defined by thermal averages of spherical harmonics and strain tensor components. In addition, we show that the backbone order parameter can be conveniently represented by an elastic dipole tensor. Treating Langmuir monolayers as disordered solids, we have derived an orientational entropy contribution to the free energy. The swiveling transition between L2(L2h) and L2′(L2*) phases is discussed in detail and is conveniently described in terms of the proposed order parameters. We discuss why the change in the distortion direction of the 2D unit cell tracks the change in tilt direction of the molecules, and also why the cell dimensions involved in the swiveling transition are the same in both phases. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 8653-8665 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Metropolis–Monte Carlo algorithms are developed to analyze the strand separation transition in circular superhelical DNA molecules. Moves that randomize the locations of unpaired regions are required in order to diminish correlations among the sampled states. This approach enables accurate simulations to be performed in reasonable computational times. Sufficient conditions to guarantee the formal correctness of the complete algorithm are proven to hold. The computation time required scales at most quadratically with molecular length, and is approximately independent of linking difference. Techniques are developed to estimate the sample size and other calculation parameters needed to achieve a specified accuracy. When the results of Monte Carlo calculations that use shuffling operations are compared with those from statistical mechanical calculations, excellent agreement is found. The Monte Carlo methodology makes possible calculations of transition behavior in cases where alternative approaches are intractable, such as in long molecules under circumstances where several runs of open base pairs occur simultaneously. It also allows the analysis of transitions in cases where the base pair separation energies vary in complex manners, such as through near-neighbor interactions, or the presence of modified bases, abasic sites, or bound molecules. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 68 (1961), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 6594-6596 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A pivot algorithm is used to numerically investigate the shape properties of linear polymers, with and without excluded volume, in two and three dimensions. The high computational efficiency of the pivot algorithm has allowed us to obtain data which is four to eight times more accurate than our previous Brownian dynamics simulations, while employing considerably less computational resources. The accurate data for long polymer chains highlight the inadequacy of the d expansion of polymer shapes to first order only.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 3976-3980 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The average asymmetry of two-, four-, and five-dimensional linear and ring polymers, with and without excluded volume, is investigated numerically via Brownian dynamics. It is found that the average asymmetry of nonexcluded volume chains is in good agreement with theoretical predictions in all dimensions studied. The distribution of the average asymmetry is also determined. This distribution indicates that two-dimensional ring chains are likely to be nearly symmetrical. Moreover, the distribution of the maximum eigenvalues of the tensor of the moment of inertia is also in agreement with the theoretical predictions.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 85 (1986), S. 6728-6731 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The shapes of two- , four- , and five-dimensional linear and ring polymers, with and without excluded volume, are investigated numerically via Brownian dynamics. It is found that the asphericity of nonexcluded volume linear polymers is in agreement with theoretical predictions in all dimensions. Agreement with available theoretical predictions is also obtained for two-dimensional nonexcluded volume ring polymers. Moreover, it is shown that excluded volume polymers become more ideal (i.e., closer to nonexcluded volume polymers) as the dimension is increased.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A magnetic pickup coil diagnostic set is used to measure the position of the plasma column in the Texas Experimental Tokamak Upgrade (TEXT-U) project. The output from this coil set is used in a digital feedback system to control the plasma position. To provide a fast time response for the feedback system, one complete coil set is located on the interior of the vacuum vessel. Another set with a slower time response is located on the outside of the vessel. To simplify and speed up data processing, the coils are constructed so that the X and Y coordinates of the plasma current centroid are each determined using the signals from only two separate coils. For each coordinate one coil is used to measure a tangential (relative to the coil surface) magnetic field component, while the second coil measures a normal field component. Due to physical constraints, the coils are not continuous around the vacuum vessel. The presence of gaps in the coils causes pickup of the external current flowing in the divertor coil windings during TEXT-U diverted discharges. This pickup has been successfully nulled out by adding a divertor current Rogowski coil to the X position coil circuit. The data indicate that these coils, along with the digital feedback system, are useful tools for flexible position control over a wide range of TEXT-U plasma parameters. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 98 (1993), S. 1611-1612 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Brownian dynamics simulations are made for continuum, excluded, and nonexcluded volume, uniform H-comb polymers in three dimensions. It is found that the end-to-end distance and radius of gyration of the inner branches are expanded more than those of the outer branches for excluded volume combs. The ratio of the end-to-end distance scaling amplitudes appears to be a universal quantity in agreement with the conjecture of Gaunt et al. [J. Phys. A 19, L811 (1986)]. Moreover, the ratio of the radii of gyration scaling amplitudes seems to be universal. The expansion effect is smaller in three dimensions than in two dimensions.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 9170-9171 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Brownian dynamics simulations are made for continuum, excluded volume, uniform H-comb polymers in two and three dimensions. It is found that the radius of gyration power law exponent is 1.50±0.01 and 1.22±0.01 in two and three dimensions, respectively. The g ratio of continuum H-combs is in excellent agreement with lattice Monte Carlo, experimental data, and renormalization group predictions in three dimensions; in two dimensions the leading order renormalization group predictions are unreliable.
    Type of Medium: Electronic Resource
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