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  • 1
    Electronic Resource
    Electronic Resource
    Design and development of an interferometer with improved angular tolerance and its application to x–y theta measurement (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 4633-4638 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Plane mirror interferometers are widely used in the measurement of x–y motions. Although large range planar motion can be measured, it suffers from very tight angular tolerance. In this article an interferometer system having improved angular range and linear resolution is developed. In the system, a tilted laser beam is incident to a plane mirror attached to a moving stage and an additional retroreflector and a plane mirror are placed off the stage to help return the measuring beam. In such a design both the resolution and angular tolerance are improved. Meanwhile, large travel ranges along both the x and y directions remain. The optical principle pertinent to the proposed optical configuration is explained and an optical path analysis is performed to establish the relation between the optical path change and the motion to be measured. Based on the established relation, design of system parameters and workspace analysis are also discussed. Experimental results including resolution test and scaling procedure are then demonstrated. Using the developed interferometer an x–y theta measurement scheme is introduced. In the proposed scheme, using three interferometers the rotation angle of an x–y theta stage can be obtained first and it can then be used to compensate errors of the measured linear motion. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1326058
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  • 2
    Electronic Resource
    Electronic Resource
    Thermodynamics of trapped interacting bosons in one dimension (2001)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 42 (2001), S. 765-772 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: On the basis of Bethe ansatz solution of bosons with δ-function interaction in a one-dimensional potential well, the thermodynamics equilibrium of the system in finite temperature is studied by using the strategy of Yang and Yang. The thermodynamics quantities, such as specific heat, etc., are obtained for the cases of the strong coupling and weak coupling limits respectively. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1331562
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  • 3
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    A comparison and evaluation of five biclustering algorithms by quantifying goodness of biclusters for gene expressi on data (2012)
    BioMed Central
    Details
    Publication Date: 2012-07-24
    Description: Background: Several biclustering algorithms have been proposed to identify biclusters, in which genes share similar expression patterns across a number of conditions. However, different algorithms would yield different biclusters and further lead to distinct conclusions. Therefore, some testing and comparisons between these algorithms are strongly required. Methods: In this study, five biclustering algorithms (i.e. BIMAX, FABIA, ISA, QUBIC and SAMBA) were compared with each other in the cases where they were used to handle two expression datasets (GDS1620 and pathway) with different dimensions in Arabidopsis thaliana (A. thaliana)GO (gene ontology) annotation and PPI (protein-protein interaction) network were used to verify the corresponding biological significance of biclusters from the five algorithms. To compare the algorithms' performance and evaluate quality of identified biclusters, two scoring methods, namely weighted enrichment (WE) scoring and PPI scoring, were proposed in our study. For each dataset, after combining the scores of all biclusters into one unified ranking, we could evaluate the performance and behavior of the five biclustering algorithms in a better way. Results: Both WE and PPI scoring methods has been proved effective to validate biological significance of the biclusters, and a significantly positive correlation between the two sets of scores has been tested to demonstrate the consistence of these two methods.A comparative study of the above five algorithms has revealed that: (1) ISA is the most effective one among the five algorithms on the dataset of GDS1620 and BIMAX outperforms the other algorithms on the dataset of pathway. (2) Both ISA and BIMAX are data-dependent. The former one does not work well on the datasets with few genes, while the latter one holds well for the datasets with more conditions. (3) FABIA and QUBIC perform poorly in this study and they may be suitable to large datasets with more genes and more conditions. (4) SAMBA is also data-independent as it performs well on two given datasets. The comparison results provide useful information for researchers to choose a suitable algorithm for each given dataset.
    Electronic ISSN: 1756-0381
    Topics: Biology , Computer Science
    Published by BioMed Central
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  • 4
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    Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus (2013)
    BioMed Central
    Details
    Publication Date: 2013-07-17
    Description: Background: Transmissible gastroenteritis coronavirus (TGEV) is an enteropathogenic coronavirus that causes diarrhea in pigs, which is correlated with high morbidity and mortality in suckling piglets. Information remains limited about the comparative protein expression of host cells in response to TGEV infection. In this study, cellular protein response to TGEV infection in swine testes (ST) cells was analyzed, using the proteomic method of two-dimensional difference gel electrophoresis (2D DIGE) coupled with MALDI-TOF-TOF/MS identification. Results: 33 differentially expressed protein spots, of which 23 were up-regulated and 10 were down-regulated were identified. All the protein spots were successfully identified. The identified proteins were involved in the regulation of essential processes such as cellular structure and integrity, RNA processing, protein biosynthesis and modification, vesicle transport, signal transduction, and the mitochondrial pathway. Western blot analysis was used to validate the changes of alpha tubulin, keratin 19, and prohibitin during TGEV infection. Conclusions: To our knowledge, we have performed the first analysis of the proteomic changes in host cell during TGEV infection. 17 altered cellular proteins that differentially expressed in TGEV infection were identified. The present study provides protein-related information that should be useful for understanding the host cell response to TGEV infection and the underlying mechanism of TGEV replication and pathogenicity.
    Electronic ISSN: 1477-5956
    Topics: Medicine
    Published by BioMed Central
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  • 5
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    Influence of glucocorticoids on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (2014)
    BioMed Central
    Details
    Publication Date: 2014-07-16
    Description: Background: Glucocorticoid has been used extensively in clinical applications, because of its several pharmacologic actions, which include immunosuppression, anti-inflammation, anti-shock, and relief of asthma. However, the long-term or high-dose application of glucocorticoid can induce adverse effects such as osteoporosis, which is known in this case as glucocorticoid-induced osteoporosis (GIOP). It is a secondary osteoporosis that results in easy fracturing, and even disability. Therefore it became a thorny issue. Methods: The rat model of glucocorticoid-induced osteoporosis (GIOP) was replicated to isolate BMSCs. Rats were assigned into four groups: normal, normal induction, GIOP, and GIOP induction. The growth cycle was monitored by using flow cytometry. Osteogenic differentiation was compared by using alkaline phosphatase (ALP) staining with a modified calcium cobalt method. The quantitative detection of osteoprotegerin and the receptor activator of nuclear factor kappa-B ligand (RANKL) was conducted by using enzyme-linked immunoassay. Finally, renal Klotho mRNA expression was assessed by using RT-PCR. Results: BMSC proliferation was reduced in GIOP rats. The ALP-positive expression of normal BMSCs to the osteogenic induction solution was stronger than that of BMSCs from GIOP rats (P 〈 0.01). Osteoprotegerin expression was significantly higher in the normal induction group than in the normal, GIOP (P 〈 0.01), and GIOP induction groups (P 〈 0.05). RANKL expression was significantly higher in the normal induction group than in the other groups (P 〈 0.01) and significantly higher in the normal group than in the GIOP and GIOP induction groups (P 〈 0.01). RT-PCR analysis showed that renal Klotho mRNA expression was significantly reduced in the GIOP group compared with the normal group (P 〈 0.01). Conclusion: BMSC proliferation, osteogenic differentiation, and reactive activity to an osteogenic inductor were reduced in GIOP rats. Klotho mRNA expression decreased during GIOP induction.
    Electronic ISSN: 1471-2474
    Topics: Medicine
    Published by BioMed Central
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  • 6
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    Evaluation and clinical significance of the stomach age model for evaluating aging of the stomach-a multicenter study in China (2014)
    BioMed Central
    Details
    Publication Date: 2014-06-29
    Description: Background: A higher prevalence of chronic atrophic gastritis (CAG) occurs in younger adults in Asia. We used Stomach Age to examine the different mechanisms of CAG between younger adults and elderly individuals, and established a simple model of cancer risk that can be applied to CAG surveillance. Methods: Stomach Age was determined by FISH examination of telomere length in stomach biopsies. Deltapsim was also determined by flow cytometry. Sixty volunteers were used to confirm the linear relationship between telomere length and age while 120 subjects were used to build a mathematical model by a multivariate analysis. Overall, 146 subjects were used to evaluate the validity of the model, and 1,007 subjects were used to evaluate the relationship between prognosis and Deltaage (calculated from the mathematical model). ROC curves were used to evaluate the relationship between prognosis and Deltaage and to determine the cut-off point for Deltaage. Results: We established that a tight linear relationship between the telomere length and the age. The telomere length was obvious different between patients with and without CAG even in the same age. Deltapsim decreased in individuals whose Stomach Age was greater than real age, especially in younger adults. A mathematical model of Stomach Age (real age + Deltaage) was successfully constructed which was easy to apply in clinical work. A higher Deltaage was correlated with a worse outcome. The criterion of Deltaage 〉3.11 should be considered as the cut-off to select the subgroup of patients who require endoscopic surveillance. Conclusion: Variation in Stomach Age between individuals of the same biological age was confirmed. Attention should be paid to those with a greater Stomach Age, especially in younger adults. The Deltaage in the Simple Model can be used as a criterion to select CAG patients for gastric cancer surveillance.
    Electronic ISSN: 1472-6890
    Topics: Medicine
    Published by BioMed Central
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  • 7
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    Device performance simulations of multilayer black phosphorus tunneling transistors (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-11-17
    Description: We report a theoretical investigation of ballistic transport in multilayer black phosphorus (BP) tunneling transistors (TFETs) with HfO 2 as the gate oxide. First-principles calculations show that monolayer BP can be preserved well on HfO 2 (111) surface. For a better device performance, the optimum layer and transport direction at different channel lengths are investigated. It is shown that BP TFETs have larger drain current in the armchair direction (AD) than in the zigzag direction, and the current difference can be several orders of magnitude. On-state current can be enhanced in the BP TFETs using thicker BP film, while the minimal leakage current is increased at the same time. To reduce the leakage current and subthreshold swing in the multilayer BP TFETs, lower source/drain doping concentration and smaller drain voltage should be applied. Compared to monolayer MoS 2 , MoSe 2 , and MoTe 2 TFETs monolayer BP TFETs in AD can reach larger on-state current at the same I on / I off ratio.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 8
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    Experimental investigation on the energy deposition and expansion rate under the electrical explosion of aluminum wire in vacuum (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-12-25
    Description: Experimental investigations on the electrical explosion of aluminum wire using negative polarity current in vacuum are presented. Current pulses with rise rates of 40 A/ns, 80 A/ns, and 120 A/ns are generated for investigating the influence of current rise rate on energy deposition. Experimental results show a significant increase of energy deposition into the wire before the voltage breakdown with the increase of current rise rate. The influence of wire dimension on energy deposition is investigated as well. Decreasing the wire length allows more energy to be deposited into the wire. The energy deposition of a 0.5 cm-long wire explosion is ∼2.5 times higher than the energy deposition of a 2 cm-long wire explosion. The dependence of the energy deposition on wire diameter demonstrates a maximum energy deposition of 2.7 eV/atom with a diameter of ∼18  μ m. Substantial increase in energy deposition is observed in the electrical explosion of aluminum wire with polyimide coating. A laser probe is applied to construct the shadowgraphy, schlieren, and interferometry diagnostics. The morphology and expansion trajectory of exploding products are analyzed based on the shadowgram. The interference phase shift is reconstructed from the interferogram. Parallel dual wires are exploded to estimate the expansion velocity of the plasma shell.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 9
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    Kabuki syndrome: a Chinese case series and systematic review of the spectrum of mutations (2015)
    BioMed Central
    Details
    Publication Date: 2015-04-22
    Description: Background: Kabuki syndrome is a rare hereditary disease affecting multiple organs. The causative genes identified to date are KMT2D and KDMA6. The aim of this study is to evaluate the clinical manifestations and the spectrum of mutations of KMT2D. Methods: We retrospectively retrieved a series of eight patients from two hospitals in China and conducted Sanger sequencing for all of the patients and their parents if available. We also reviewed the literature and plotted the mutation spectrum of KMT2D. Results: The patients generally presented with typical clinical manifestations as previously reported in other countries. Uncommon symptoms included spinal bifida and Dandy-Walker malformation. With respect to the mutations, five mutations were found in five patients, including two frameshift indels, one nonsense mutation and two missense mutations. Conclusions: This is the first case series on Kabuki syndrome in Mainland China. Unusual symptoms, such as spinal bifida and Dandy-Walker syndrome, suggested that neurological developmental defects may accompany Kabuki syndrome. This case series helps broaden the mutation spectrum of Kabuki syndrome and adds information regarding the manifestations of Kabuki syndrome.
    Electronic ISSN: 1471-2350
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 10
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    Broad autism phenotype features of Chinese parents with autistic children and their associations with severity of social impairment in probands (2015)
    BioMed Central
    Details
    Publication Date: 2015-07-24
    Description: Background: Parents of children with autism have higher rates of broad autism phenotype (BAP) features than parents of typically developing children (TDC) in Western countries. This study was designed to examine the rate of BAP features in parents of children with autism and the relationship between parental BAP and the social impairment of their children in a Chinese sample. Methods: A total of 299 families with autistic children and 274 families with TDC participated in this study. Parents were assessed using the Broad Autism Phenotype Questionnaire (BAPQ), which includes self-report, informant-report, and best-estimate versions. Children were assessed using the Chinese version of the Social Responsiveness Scale (SRS). Results: Parents of children with autism were significantly more likely to have BAP features than were parents of TDC; mothers and fathers in families with autistic children had various BAP features. The total scores of the informant and best-estimate BAPQ versions for fathers were significantly associated with their children’s SRS total scores in the autism group, whereas the total scores of the three BAPQ versions for mothers were significantly associated with their children’s SRS total scores in the TDC group. In the autism group, the total SRS scores of children with “BAP present” parents (informant and best-estimate) were higher than the total SRS scores of children with“BAP absent” parents. In the TDC group, the total SRS scores of children with “BAP present” parents were higher than the total SRS scores of children with“BAP absent” parents (best-estimate). Conclusions: Parents of autistic children were found to have higher rates of BAP than parents of TDC in a sample of Chinese parents. The BAP features of parents are associated with their children’s social functioning in both autism families and TDC families, but the patterns of the associations are different.
    Electronic ISSN: 1471-244X
    Topics: Medicine
    Published by BioMed Central
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