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  • BioMed Central  (30)
  • Nature Publishing Group (NPG)  (21)
  • American Institute of Physics (AIP)  (5)
  • Royal Society of Chemistry (RSC)  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Interfacial dynamics and formation of porous structures (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 4324-4331 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A computer simulation study of a two-dimensional two-component resistor network model is presented. The model is constructed to elucidate the relationship between interfacial dynamics and formation of porous structures. The interfacial dynamics, which are stochastic in nature, have been studied and the effect of both global and regional characteristics in interfacial dynamics on the resulting morphologies has been investigated. In the simulation, the advancing interface exhibits either an unstable front as dictated by the Mullins–Sekerka instability, or a stable one that is roughened by kinetic noise. The relevance of the simulation to the experimental observations of porous silicon formation is demonstrated and the implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.352816
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The realizations of quantum groups of An−1 and Cn types in q-deformed oscillator systems at classical and quantum levels (1991)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 32 (1991), S. 3241-3245 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: In the classical q-deformed oscillators system, the Poisson bracket realizations of the quantum enveloping algebras of An−1 and Cn types are given in the symplectic space (V,Ω) (without deformation). When the oscillators system is canonically quantized, the Lie bracket realizations of the quantum enveloping algebras of An−1 and Cn types are obtained. The Hopf structures of these quantum enveloping algebras are supplied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.529484
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    Paper (German National Licenses)
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  • 3
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    Specific ion effects of ionic liquids on enzyme activity and stability (2011)
    Royal Society of Chemistry (RSC)
    Details
    Publication Date: 2011-06-04
    Description: Ionic liquids composed of chaotropic cations (favorably with H-bonding capability) and kosmotropic anions are favored for biocatalysis. Jing-Qi Lai, Zhuang Li, Yan-Hong Lu, Zhen Yang ( from Green Chem.) Jing-Qi Lai, Green Chem., 2011, DOI: 10.1039/C1GC15140A To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1463-9262
    Electronic ISSN: 1463-9270
    Topics: Chemistry and Pharmacology
    Published by Royal Society of Chemistry (RSC)
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  • 4
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    Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis (2011)
    Royal Society of Chemistry (RSC)
    Details
    Publication Date: 2011-06-17
    Description: A novel BLAP (alkaline protease from Bacillus licheniformis) catalyzed synthesis of 2H-1-benzopyran-2-one derivatives was achieved by domino reaction. Chang-Heng Wang, Zhi Guan, Yan-Hong He ( from Green Chem.) Chang-Heng Wang, Green Chem., 2011, DOI: 10.1039/C0GC00799D To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1463-9262
    Electronic ISSN: 1463-9270
    Topics: Chemistry and Pharmacology
    Published by Royal Society of Chemistry (RSC)
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  • 5
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    Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces (2013)
    BioMed Central
    Details
    Publication Date: 2013-07-18
    Description: Background: Hyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease. Therefore, we studied the prevalence of HUA and associated risk factors in the population of two provinces in northern China. Methods: Based on the research of Chinese Physiological Constant and Health Conditions conducted in 2008--2010, we enrolled 29,639 subjects in a randomized, stratified study in four sampling areas in Heilongjiang Province and the Inner Mongolia Autonomous Region. We collected 13,140 serum samples to determine biochemical indicators including uric acid(UA), glucose, blood lipids, liver function, and renal function, and finally a representative sample of 8439 aged 18 years and older was determined. We also defined and stratified HUA, hypertension, diabetes, obesity and lipid abnormalities according to international guidelines. Results: There were significant differences in the UA levels between different genders and regions. The total prevalence of HUA is 13.7%. Men had a higher prevalence of HUA than women (21% vs. 7.9%; P 〈 0.0001). As age increased, HUA prevalence decreased in men but rose in women. The suburbs of big cities had the highest HUA prevalence (18.7%), and in high-prevalence areas the proportion of women with HUA also increased. A stepwise logistic regression model was used to filter out twelve HUA risk factors, including age, gender, residence, hypercholesterolemia, hypertriglyceridemia, impaired fasting glucose, hypertension, obesity, abdominal obesity, CKD, drinking and sleeping. After adjusting for these factors, the odds ratio of HUA was 1.92 times higher in men than in women. Compared with agricultural and pastoral areas, the odds ratio of having HUA was 2.14 for participants in the suburbs of big cities and 1.57 in the center of big cities. Conclusions: The prevalence of HUA is high in northern China. The differences in HUA prevalence by geographic region suggested that unbalanced economic development and health education, therefore HUA prevention measures should be strengthened to improve quality of life and reduce health care costs.
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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  • 6
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    Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration (2015)
    BioMed Central
    Details
    Publication Date: 2015-08-14
    Description: Background: Ductal carcinoma in situ (DCIS) is a non-obligate precursor lesion of invasive breast cancer in which approximately half the patients will progress to invasive cancer. Gaining a better understanding of DCIS progression may reduce overtreatment of patients. Expression of the pro-inflammatory cytokine interleukin-6 increases with pathological stage and grade, and is associated with poorer prognosis in breast cancer patients. Carcinoma associated fibroblasts (CAFs), which are present in the stroma of DCIS patients are known to secrete pro-inflammatory cytokines and promote tumor progression. Methods: We hypothesized that IL-6 paracrine signaling between DCIS cells and CAFs mediates DCIS proliferation and migration. To test this hypothesis, we utilized the mammary architecture and microenvironment engineering or MAME model to study the interactions between human breast CAFs and human DCIS cells in 3D over time. We specifically inhibited autocrine and paracrine IL-6 signaling to determine its contribution to early stage tumor progression. Results: Here, DCIS cells formed multicellular structures that exhibited increased proliferation and migration when cultured with CAFs. Treatment with an IL-6 neutralizing antibody inhibited growth and migration of the multicellular structures. Moreover, selective knockdown of IL-6 in CAFs, but not in DCIS cells, abrogated the migratory phenotype. Conclusion: Our results suggest that paracrine IL-6 signaling between preinvasive DCIS cells and stromal CAFs represent an important factor in the initiation of DCIS progression to invasive breast carcinoma.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 7
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    PRL-3 Promotes the Malignant Progression of Melanoma via Triggering Dephosphorylation and Cytoplasmic Localization of NHERF1 (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-08-14
    Description: PRL-3 Promotes the Malignant Progression of Melanoma via Triggering Dephosphorylation and Cytoplasmic Localization of NHERF1 Journal of Investigative Dermatology 135, 2273 (September 2015). doi:10.1038/jid.2015.154 Authors: Xian-Ying Fang, Ran Song, Wei Chen, Yuan-Yuan Yang, Yan-Hong Gu, Yong-Qian Shu, Xu-Dong Wu, Xue-Feng Wu, Yang Sun, Yan Shen & Qiang Xu
    Print ISSN: 0022-202X
    Electronic ISSN: 1523-1747
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 8
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    RNA-seq analysis reveals the role of red light in resistance against Pseudomonas syringae pv. tomato DC3000 in tomato plants (2015)
    BioMed Central
    Details
    Publication Date: 2015-02-28
    Description: Background: Plants attenuate their responses to a variety of bacterial and fungal pathogens, leading to higher incidences of pathogen infection at night. However, little is known about the molecular mechanism responsible for the light-induced defence response; transcriptome data would likely facilitate the elucidation of this mechanism. Results: In this study, we observed diurnal changes in tomato resistance to Pseudomonas syringae pv. tomato DC3000 (Pto DC3000), with the greatest susceptibility before midnight. Nightly light treatment, particularly red light treatment, significantly enhanced the resistance; this effect was correlated with increased salicylic acid (SA) accumulation and defence-related gene transcription. RNA-seq analysis revealed that red light induced a set of circadian rhythm-related genes involved in the phytochrome and SA-regulated resistance response. The biosynthesis and signalling pathways of multiple plant hormones (auxin, SA, jasmonate, and ethylene) were co-ordinately regulated following Pto DC3000 infection and red light, and the SA pathway was most significantly affected by red light and Pto DC3000 infection. This result indicates that SA-mediated signalling pathways are involved in red light-induced resistance to pathogens. Importantly, silencing of nonexpressor of pathogensis-related genes 1 (NPR1) partially compromised red light-induced resistance against Pto DC3000. Furthermore, sets of genes involved in redox homeostasis (respiratory burst oxidase homologue, RBOH; glutathione S-transferases, GSTs; glycosyltransferase, GTs), calcium (calmodulin, CAM; calmodulin-binding protein, CBP), and defence (polyphenol oxidase, PPO; nudix hydrolase1, NUDX1) as well as transcription factors (WRKY18, WRKY53, WRKY60, WRKY70) and cellulose synthase were differentially induced at the transcriptional level by red light in response to pathogen challenge. Conclusions: Taken together, our results suggest that there is a diurnal change in susceptibility to Pto DC3000 with greatest susceptibility in the evening. The red light induced-resistance to Pto DC3000 at night is associated with enhancement of the SA pathway, cellulose synthase, and reduced redox homeostasis.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 9
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    A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-11-01
    Description: Article Using molecular markers is a useful way to predict the prognosis of cancer patients. Here, Wei et al. describe a five gene methylation signature that can predict the prognosis of renal clear cell cancer and validate its use in multiple patient cohorts. Nature Communications doi: 10.1038/ncomms9699 Authors: Jin-Huan Wei, Ahmed Haddad, Kai-Jie Wu, Hong-Wei Zhao, Payal Kapur, Zhi-Ling Zhang, Liang-Yun Zhao, Zhen-Hua Chen, Yun-Yun Zhou, Jian-Cheng Zhou, Bin Wang, Yan-Hong Yu, Mu-Yan Cai, Dan Xie, Bing Liao, Cai-Xia Li, Pei-Xing Li, Zong-Ren Wang, Fang-Jian Zhou, Lei Shi, Qing-Zuo Liu, Zhen-Li Gao, Da-Lin He, Wei Chen, Jer-Tsong Hsieh, Quan-Zhen Li, Vitaly Margulis, Jun-Hang Luo
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia (2015)
    BioMed Central
    Details
    Publication Date: 2015-10-22
    Description: Background: Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gene regulated by promoter hypermethylation in various types of human cancers although the expression and promoter methylation of GATA4 in pediatric AML is still unclear. Methods: Transcriptional expression levels of GATA4 were evaluated by semi-quantitative and real-time PCR. Methylation status was investigated by methylation-specific PCR (MSP) and bisulfate genomic sequencing (BGS). The prognostic significance of GATA4 expression and promoter methylation was assessed in 105 cases of Chinese pediatric acute myeloid leukemia patients with clinical follow-up records. Results: MSP and BGS analysis showed that the GATA4 gene promoter is hypermethylated in AML cells, such as the HL-60 and MV4-11 human myeloid leukemia cell lines. 5-Aza treatment significantly upregulated GATA4 expression in HL-60 and MV4-11 cells. Aberrant methylation of GATA4 was observed in 15.0 % (3/20) of the normal bone marrow control samples compared to 56.2 % (59/105) of the pediatric AML samples. GATA4 transcript levels were significantly decreased in AML patients (33.06 ± 70.94; P = 0.011) compared to normal bone marrow/idiopathic thrombocytopenic purpura controls (116.76 ± 105.39). GATA4 promoter methylation was correlated with patient leukocyte counts (WBC, white blood cells) (P = 0.035) and minimal residual disease MRD (P = 0.031). Kaplan-Meier survival analysis revealed significantly shorter overall survival time in patients with GATA4 promoter methylation (P = 0.014). Conclusions: Epigenetic inactivation of GATA4 by promoter hypermethylation was observed in both AML cell lines and pediatric AML samples; our study implicates GATA4 as a putative tumor suppressor gene in pediatric AML. In addition, our findings imply that GATA4 promoter methylation is correlated with WBC and MRD. Kaplan-Meier survival analysis revealed significantly shorter overall survival in pediatric AML with GATA4 promoter methylation but multivariate analysis shows that it is not an independent factor. However, further research focusing on the mechanism of GATA4 in pediatric leukemia is required.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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