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  • 1
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Bonding of silicon directly to silicon is possible with proper preparation of the two surfaces to be bonded. The advantage of such a method is that a bonding agent is not required, and direct bonding avoids figure errors introduced by thickness variations in a bonding agent. We have succeeded in bonding a 3-inch-diameter diced (1 mm × 1 mm) silicon(111) oriented wafer to a silicon concave spherical form having a 3-m radius. A very good rms figure error of 0.059 millirad over the entire area of the analyzer was measured. The suitability for x-ray inelastic scattering due to introduced strain is, however, still an open question. Whether or not deleterious strain is unavoidably introduced during the bonding process is a question we will answer with availability of photons on sector 3 of the SRI CAT at the Advanced Photon Source. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 8593-8597 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Large negative magnetoresistance (MR) is observed in Fe–xCr–10Co (x=10,20,30,40,50,- 60,70, and 80 wt %) ternary heterogeneous alloy films prepared by the IBS (ion beam sputter) deposition process. All the as-deposited films consisted of the α phase alone. After aging treatment, the α phase is decomposited into two phases: the α1 (Fe–Co rich phase) and α2 (Cr rich phase). In the granular alloy, the GMR effect is obtained by virtue of the interface scattering between α1 and α2. After isothermal aging at 400 °C for 1 h, the largest MR of −27% appears around the Cr content of 60 wt % at 77 K and 14 kOe. The MR ratio of Fe–50Cr–10Co and Fe–70Cr–10Co is −12% and −20%, respectively, at the same condition. The MR ratio is also obviously effected by the Cr (or Fe) content in the alloy system. © 1996 American Institute of Physics.
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 4523-4527 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this study, the giant magnetoresistance (MR) effect was observed in Fe–XCr–Co (WFe/WCo=1, X=27, 40, 50, 60, 70, and 80 wt %) ternary heterogeneous alloy films. After aging, the separated phases and lattice images of the α1 (Fe–Co rich phase) and α2 (Cr rich phase) were further determined by high resolution transmission electron microscope. Experimental results indicate that the MR variations in Fe–Cr–Co thin films alloys were associated with the heterogeneous microstructure. By isothermal aging at 550 °C for 80 min, the largest MR of −43% appears for the film with the composition of 40(Fe/Co)–60Cr at 77 K under a field of 14 kOe. At the same treatment condition, the MR ratios of 50(Fe/Co)–50Cr and 30(Fe/Co)–70Cr are −13.2% and −21.3%, respectively. Cr content, therefore, significantly affected the MR ratio. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 60 (1986), S. 3732-3734 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Asymmetry introduced to an otherwise planar phased array Bragg cell transducer design results in the elimination of one of two steering acoustic wave fronts. Therefore, all of the acoustic power is applied to the acousto-optic interaction process. In addition, a factor of 1.8 improvement in wide-band acousto-optic Bragg cell interaction efficiency is realized over the planar phased array design. The technique to establish the asymmetry was to use a periodic silver film as a quarter-wave step. This new technique is particularly suitable for the construction of wideband Bragg cells at microwave frequencies.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1291-1296 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A multiorifice spray generator with two different modes of operation is developed. The impulse jet operation mode covers a wide range of droplet frequencies and produces arrays of droplets with controllable spacing, but with a wide size spectrum. This ejector also operates in pressurized flow mode. In this mode, optimum disturbance frequency breaks up the liquid jets into uniform size droplets, resulting in a monosized spray. Precise control of fuel flow rate and droplet size is achieved.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 1509-1511 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In situ epitaxial growth of YBa2Cu3O7−x superconducting thin films on (100)BaF2 substrates has been successful by an off-axis dc planar magnetron sputtering method. The zero-resistance temperatures of these thin films are about 81–84 K with transition width of 1.5 K. The characteristics of the films were examined by x-ray diffraction, reflection high energy electron diffraction, Rutherford backscattering spectroscopy ion channeling techniques, and scanning electron microscopy. The experimental results suggest that BaF2 is a promising material as substrates or buffer layers for the epitaxial growth of high Tc superconducting thin films, especially in high frequency applications. Discussions on the heteroepitaxy of the YBCO/BaF2 system are propounded.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 317-321 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This article presents the giant magnetoresistance (GMR) effect and microstructure of Fe-60Cr-XCo ternary heterogeneous alloy films. After ion beam sputtering, the films are heat treated at a temperature within the miscibility gap. The separated phases and lattice images of the α1 (Fe–Co rich phase) and α2 (Cr rich phase) are further determined by high resolution transmission electron microscopy. In the granular alloy, the GMR effect is obtained by the interface scattering between the phases of α1 and α2. By isothermal aging at 550 °C for 80 min, the largest MR ratio of −62% appears for the film with the composition of Fe-60Cr-15Co at 77 K under a field of 14 kOe. For the same treatment, the MR ratios of Fe-60Cr-10Co and Fe-60Cr-20Co are −39% and −43%, respectively. The Co content and heat treatment condition in the alloy system obviously affect the MR ratio. © 1997 American Institute of Physics.
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  • 8
    Publication Date: 2015-10-09
    Description: Objective Although both innate and adaptive responses to microbiota have been implicated in the pathogenesis of IBD, it is still largely unknown how they are regulated during intestinal inflammation. In this report, we investigated the role of microRNA (miR)-10a, a small, non-coding RNA, in the regulation of innate and adaptive responses to microbiota in IBD. Methods miR-10a expression was analysed in the inflamed mucosa of IBD patients treated with or without antitumour necrosis factor (anti-TNF) monoclonal antibodies (mAb) (infliximab) by qRT-PCR. Human monocyte-derived dendritic cells (DC) and IBD CD4 + T cells were transfected with miR-10a precursor to define their effect on the function of DC and CD4 + T cells. Results The expression of miR-10a was markedly decreased, while NOD2 and interleukin (IL)-12/IL-23p40 were significantly increased, in the inflamed mucosa of IBD patients compared with those in healthy controls. Commensal bacteria, TNF and interferon- inhibited human DC miR-10a expression in vitro . Anti-TNF mAb treatment significantly promoted miR-10a expression, whereas it markedly inhibited NOD2 and IL-12/IL-23p40 in the inflamed mucosa. We further identified NOD2, in addition to IL-12/IL-23p40, as a target of miR-10a. The ectopic expression of the miR-10a precursor inhibited IL-12/IL-23p40 and NOD2 in DC. Moreover, miR-10a was found to markedly suppress IBD T helper (Th)1 and Th17 cell responses. Conclusions Our data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses. Thus, miR-10a could play a role in the pathogenesis and progression of IBD.
    Print ISSN: 0017-5749
    Electronic ISSN: 1468-3288
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 9
    Publication Date: 2013-03-02
    Description: Objective This study investigated the epigenetic role of PRL-3, a key metastasis gene in colorectal cancer (CRC), as a regulator of histone demethylation and the functions of Jumonji domain-containing protein 1B (JMJD1B) and JMJD2B in the progression of CRC. Methods PRL-3-associated proteins were analysed using functional distribution and category enrichment analysis. Western blotting and immunofluorescence were used to detect nuclear PRL-3. The relationship between PRL-3 and JMJD1B or JMJD2B and the roles of JMJD1B, JMJD2B and PRL-3 in histone demethylation were determined after these proteins were knocked down using RNA interference. Case–control studies on JMJD1B and JMJD2B in patients with CRC were performed using immunohistochemical analysis. The in vitro functional effects of JMJD2B and JMJD1B were examined further. Results JMJD1B and JMJD2B, two histone demethylases, were enriched among PRL-3-associated proteins. Nuclear PRL-3 was observed in CRC cells and clinical samples of CRC. The expression of nuclear PRL-3 was increased in patients with CRC at more advanced Dukes' stages. PRL-3 was involved in the regulation of histone methylation by affecting the activities of JMJD1B and JMJD2B. A low expression of the JMJD1B protein was positively correlated with the lymph node status (p=0.032), Dukes' classification (p=0.008) and TNM staging (p=0.022) of patients with CRC. A high expression of JMJD2B was positively correlated with the lymph node status (p=0.03), Dukes' classification (p=0.036) and tumour invasion (p=0.003) of patients with CRC. A loss-of-function analysis confirmed that JMJD2B promoted the proliferation, colony formation and migration of human CRC cells. Conclusion Our data reveal a new role for PRL-3 as a key regulator of histone demethylation. JMJD1B seems to be a candidate tumour suppressor and JMJD2B seems to be a potential oncoprotein in the development and progression of CRC.
    Keywords: Colon cancer
    Print ISSN: 0017-5749
    Electronic ISSN: 1468-3288
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 10
    Publication Date: 2015-10-10
    Description: FePd (001) films, prepared by an electron beam deposition system on MgO(100), exhibit a perpendicular magnetic anisotropy (1.7 × 10 7  erg/cc) with a high order parameter (0.92). The relation between stacking faults induced by the strain relaxation, which act as strong domain wall pinning sites, and the perpendicular coercivity of (001) oriented L 1 0 FePd films prepared at different temperatures have been investigated. Perpendicular coercivity can be apparently enhanced by raising the stacking fault densities, which can be elevated by climbing dissociation of total dislocation. The increased stacking fault densities (1.22 nm −2 ) with large perpendicular coercivity (6000 Oe) are obtained for samples prepared at 650 °C. This present work shows through controlling stacking fault density in FePd film, the coercivity can be manipulated, which can be applied in future magnetic devices.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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