Publikationsdatum:
2016-06-22
Beschreibung:
Background— Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. Methods and Results— Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4–7 years), puberty (8–12 years), and postpuberty (13–20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 ( ITGA11 , located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty ( P =2.86 x 10 –8 ) and rs872256 during puberty ( P =8.67 x 10 –9 ). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P 〈5 x 10 –3 . Using a P value threshold of 〈5 x 10 –3 , we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms. Conclusions— Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
Schlagwort(e):
Epidemiology, Genetic, Association Studies, High Blood Pressure, Meta Analysis
Print ISSN:
1942-325X
Digitale ISSN:
1942-3268
Thema:
Medizin
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