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  • American Institute of Physics (AIP)  (4)
  • Blackwell Science, Ltd  (2)
  • American Heart Association (AHA)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 2471-2475 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We investigated theoretically the geminate electron–ion recombination in the limit of large electron mean free path by using the concept of diffusion in energy space. The energy diffusion equation is derived and the energy diffusion coefficient is evaluated. An analytical expression for the escape probability of the electron–ion pair is derived. It reproduces the numerical results very well which were obtained previously by using a Monte Carlo method. Experimental implications of the present theoretical findings are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 3003-3010 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Significant large-scale modification of the surface of Al–Si conductors was observed, due to electromigration in wide lines and under low stress conditions. After electromigration stressing the Al layers showed local thickness variations, i.e., damage by thinning. The mechanism underlying this damage causes substantial metal transport. Nevertheless, damage by thinning has received little attention in the past. Thinning was observed: (1) in a number of different alloys (Al–Si, Al–Cu, Al–Si–V, and Al–Si–V–Pd), (2) with a number of different underlayers [SiO2, W–Ti (no vacuum break after Al deposition) and W–Ti (oxidized surface before Al deposition)], (3) over an extended temperature range, (4) over a range of current density, and (5) in structures with and without passivation. The results show that thinning is a general phenomenon. An activation energy of approximately 0.5 eV was determined for the temperature dependence of a combined mechanism of concurrent thinning plus voiding in Al99Si1. Several alternatives are examined to explain the observations, namely mass movement along dislocations, Al bulk diffusion, and diffusion at the interface between the Al and its oxide. It is shown that diffusion at the Al/Al oxide interface most probably plays an important role in the damage mechanism, even under stress conditions where grain boundary diffusion is traditionally thought to dominate. Results also showed that alloying of Al with Pd can reduce the effects of damage by thinning. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 55-57 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The energy levels of very short-period (GaAs)n-(AlAs)n superlattices (n≤4) were investigated by photoluminescence (PL). The results show that these superlattices are type II but the lowest conduction bands are Xx,y for n≤3 and Xz for n=4, respectively. (Here Xz is the valley with k parallel to the growth axis.) In both cases the X valleys are very close to each other. PL decay, PL excitation, and PL under uniaxial stress confirm this identification. Al0.5Ga0.5As shows very different behavior, showing that even for n=1 our samples are true superlattices.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 953-962 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The exact eigenvalues for the ground state and the excitation spectra were obtained for a system with two electrons on two sites, taking into account the transfer energy, the Coulomb repulsion on the same site, and the intersite correlation energy. The vibrational modes couple linearly to the electronic density. We discuss the interplay of these interactions resulting in different phases of distorted and undistorted eigenstates with corresponding localized and delocalized electronic wave functions and accompanying charge transfer. Several simple approximation schemes generalizable to larger systems are evaluated. The comparison with the exact results shows that their validity depends strongly on the system parameters. The according limits of applicability are discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The immunocytochemical localization of the plasma membrane H+-ATPase in epidermal cells of tomato roots was studied using a monoclonal antibody raised against purified maize P-type H+-ATPase. Plants subjected to iron starvation exhibited increased proton extrusion that was confined to the root elongation zones. Immunogold labelling of the H+-ATPase on the plasma membrane was considerably higher in rhizodermal cells within zones with intense proton extrusion than in non-acidifying areas of the roots. Transfer cells were formed in rhizodermal cells of Fe-deficient plants. Quantitative determination of immunolabelling revealed that the density of PM H+-ATPase in transfer cells was about twice that of ordinary epidermal cells. In transfer cells, H+-ATPase was most abundant on the plasma membrane lining the labyrinthine invaginations of the peripheral cell wall. While the number of immunologically detectable ATPase molecules in transfer cells was not spatially correlated with proton extrusion activity, the frequency of transfer cells was considerably higher in acidifying root areas relative to non-active segments. Split-root experiments indicated that both the steady-state level of plasma membrane H+-ATPase and proton extrusion activity are systemically regulated, indicating inter-organ regulation of rhizosphere acidification. Exogenous application of the auxin analog 2,4-dichlorophenoxyacetic acid and the ethylene precursor 1-aminocyclopropane-1-carboxlic acid caused the formation of transfer cells at a frequency similar to that observed in Fe-deficient roots. However, the number of proton pumps was not affected by the hormone treatment, suggesting that both responses are regulated independently. It is concluded that transfer cells in the rhizodermis may be important but not crucial for rhizosphere acidification.
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Parkinson's disease is characterized not only by a progressive loss of dopaminergic neurons in the substantia nigra but also by a degeneration of locus coeruleus noradrenergic neurons. The present study addresses the question of whether a partial neurodegeneration of dopaminergic neurons using 6-hydroxydopamine in rat, not sufficient to produce motor disturbances, is potentiated by prior selective denervation of locus coeruleus noradrenergic terminal fields using N-ethyl-2-bromobenzylamine. Two types of denervations, one causing dopamine deficiency alone and the other causing noradrenaline and dopamine deficiency, were performed. Noradrenaline, 5-hydroxytryptamine, 5-hydroxyindole acetic acid, dopamine and its metabolites were analysed in various brain regions. Behaviour was evaluated by catalepsy tests and activity box. N-ethyl-2-bromobenzylamine selectively depleted noradrenaline from neurons of locus coeruleus origin. Decreased dopamine content in the striatum, substantia nigra and pre-frontal cortex was observed after dopaminergic lesion with 6-hydroxydopamine (42.9%). Additional locus coeruleus noradrenaline depletion with N-ethyl-2-bromobenzylamine aggravated the dopamine depletion (61.2%). The lesion in the noradrenergic and dopaminergic neurodegenerated group was not sufficient to induce consistent catalepsy and akinesia. However, after a subthreshold dose of haloperidol (0.1 mg/kg), the expression of catalepsy and akinesia was strong in the dual-lesioned group and less in the 6-hydroxydopamine-lesioned group. These results indicate that denervation of locus coeruleus noradrenergic terminals with N-ethyl-2-bromobenzylamine potentiates the 6-hydroxydopamine-induced partial dopaminergic neurodegeneration and parkinsonian symptoms. Based on the present findings and existing reports, it can be concluded that noradrenergic neurons of locus coeruleus have neuromodulatory and neuroprotective properties on the dopaminergic neurons of basal ganglia and that noradrenergic degeneration may contribute to the aetiology and pathophysiology of Parkinson's disease.
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  • 7
    Publication Date: 2012-08-28
    Description: Background and Purpose— Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke. Methods— We analyzed 2500 young (18–55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method. Deep WMHs on MRI were classified by the Fazekas score. Multivariate analysis was performed using a regression model with random effects. Results— Mean eGFR was 96.7 mL/min in those with WMH Grade 0 to 1 (none to mild), 90.7 mL/min in WMH Grade 2 (moderate), and 89 mL/min in WMH Grade 3 (severe). Univariate analysis revealed WMH to be associated with age ( P 〈0.001), hypertension ( P 〈0.001), cardiovascular disease ( P =0.015), overweight (body mass index 〉25 kg/m 2 ; P =0.013), current smoking ( P =0.044), and eGFR ( P =0.009). In multivariate analysis, age, hypertension, and eGFR remained associated with WMH severity. Conclusions— In young patients with acute ischemic stroke, lower eGFR values in the normal range are associated with the presence of moderate to severe WMH. Clinical Trial Registration— URL: http://clinicaltrials.gov . Unique Identifier: NCT00414583.
    Keywords: Risk Factors for Stroke
    Print ISSN: 0039-2499
    Electronic ISSN: 1524-4628
    Topics: Medicine
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