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  • BioMed Central  (17)
  • American Institute of Physics (AIP)  (7)
  • American Geophysical Union  (1)
  • Molecular Diversity Preservation International (MPDI)  (1)
  • 1
    Publication Date: 2022-10-26
    Description: Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 125(5), (2020): e2020JC016123, doi:10.1029/2020JC016123.
    Description: The processes underlying the strong Kuroshio encountering a cape at the southernmost tip of Taiwan are examined with satellite‐derived chlorophyll and temperature maps, a drifter trajectory, and realistic model simulations. The interaction spurs the formation of submesoscale cyclonic eddies that trap cold and high‐chlorophyll water and the formation of frontal waves between the free stream and the wake flow. An observed train of eddies, which have relative vorticity about one to four times the planetary vorticity (f), is shed from the recirculation that occurs in the immediate lee of the cape as a result of flow separation. These propagate downstream at a speed of 0.5–0.6 m s−1. Farther downstream, the corotation and merging of two or three adjacent eddies are common owing to the topography‐induced slowdown of eddy propagation farther downstream. It is found that the relative vorticity of a corotating system (1.2f) is 70% weaker than that of a single eddy due to the increase of eddy diameter from ~16 to ~33 km, in agreement with Kelvin's circulation theorem. The shedding period of the submesoscale eddies is strongly modulated by either diurnal or semidiurnal tidal flows, which typically reach 0.2–0.5 m s−1, whereas its intrinsic shedding period is insignificant. The frontal waves predominate in the horizontal free shear layer emitted from the cape, as well as a density front. Energetics analysis suggests that the wavy features result primarily from the growth of barotropic instability in the free shear layer, which may play a secondary process in the headland wake.
    Description: Yu‐Hsin Cheng was supported by the CWB of Taiwan through Grant 1062076C. Ming‐Huei Chang was supported by the Ministry of Science and Technology of Taiwan (MOST) under Grants 103‐2611‐M‐002‐018, 105‐2611‐M‐002‐012, and 107‐2611‐M‐002‐015. Sen Jan was supported with MOST Grants 101‐2611‐M‐002‐018‐MY3, 103‐2611‐M‐002‐011, and 105‐2119‐M‐002‐042. Magdalena Andres was supported by the U.S. Office of Naval Research Grant N000141613069.
    Description: 2020-10-23
    Keywords: Kuroshio ; Submesoscale eddy ; Headland ; Recirculation ; Eddy corotation ; Barotropic instability
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 3550-3557 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Destruction of benzene in a benzene/Ar mixture subjected to a pulsed glow discharge was studied. The destruction efficiency was much improved compared to a dc glow discharge, and the destruction efficiency increased with decreasing pulse width at a constant pulse frequency. Diagnostics experiments were conducted to elucidate the destruction mechanisms involved. The results show that excitation transfer from the metastable states of Ar to benzene in the afterglow of the discharge was primarily responsible for the destruction of benzene. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2012-09-30
    Description: Background: Chronic kidney disease (CKD) is more prevalent in Taiwan than in most countries. This population-based cohort study evaluated the dementia risk associated with CKD. Methods: Using claims data of 1,000,000 insured residents covered in the universal health insurance of Taiwan, we selected 37049 adults with CKD newly diagnosed from 2000--2006 as the CKD cohort. We also randomly selected 74098 persons free from CKD and other kidney diseases, frequency matched with age, sex and the date of CKD diagnosed. Incidence and hazard ratios (HRs) of dementia were evaluated by the end of 2009. Results: Subjects in the CKD cohort were more prevalent with comorbidities than those in the non-CKD cohort (p
    Electronic ISSN: 1471-2369
    Topics: Medicine
    Published by BioMed Central
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  • 4
    Publication Date: 2014-07-24
    Description: The cellular signal transduction is commonly believed to rely on the direct “contact” or “binding” of the participating molecule reaction that depends positively on the corresponding molecule concentrations. In living systems, however, it is somewhat difficult to precisely match the corresponding rapid “binding,” depending on the probability of molecular collision, existing in the cellular receptor-ligand interactions. Thus, a question arises that if there is another mechanism (i.e., bindingless ) that could promote this signal communication. According to this hypothesis, we report a cellular model based on the examination of intracellular calcium concentration to explore whether the unidentified signal delivery in cells exists, via a microfluidic device. This device was designed to isolate the cells from directly contacting with the corresponding ligands/molecules by the particular polydimethylsiloxane (PDMS) membranes with different thicknesses. Results show a significant increment of calcium mobilization in human prostate cancer PC-3 cells by the stimulation of endothelin-1, even up to a separated distance of 95  μ m. In addition, these stimulated signals exhibited a bump-shaped characteristics depending on the membrane thickness. When the PDMS membrane is capped by SiO 2 , a particular trait that resembles the ballistic signal conduction was observed. A theoretical model was developed to describe the signal transport process across the PDMS membrane. Taken together, these results indicate that the unidentified signal (ligand structural information) delivery could occur in cells and be examined by the proposed approach, exhibiting a bindingless communication manner. Moreover, this approach and our finding may offer new opportunities to establish a robust and cost-effective platform for the study of cellular biology and new drug development.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 5
    Publication Date: 2014-06-08
    Description: Background: Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1 rs13306731) in lipid metabolism-related genes, aimed to shed light on the influence of these SNPs on individual susceptibility to MI. Methods: Genotyping of the three SNPs (rs2302685, rs6687605 and rs13306731) was performed in 285 MI cases and 650 control subjects using polymerase chain reaction-ligation detection reaction (PCR-LDR) method. The association of these SNPs with MI and lipid profiles was performed with SPSS software. Results: Multivariate logistic regression analysis showed that C allele (OR = 1.62, P = 0.039) and the combined CT/CC genotype (OR = 1.67, P = 0.035) of LRP6 rs2302685 were associated with increased MI risk, while the other two SNPs had no significant effect. Further stratified analysis uncovered a more evident association with MI risk among younger subjects (
    Electronic ISSN: 1476-511X
    Topics: Biology
    Published by BioMed Central
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  • 6
    Publication Date: 2014-06-10
    Description: Silver nanorod (Ag NR) arrays with average diameter about 18 nm and period about 50 nm were electrodeposited in anodic aluminum oxide (AAO) templates. The filling factor of Ag NRs in the AAO nanopores could be adjusted by the deposition temperature. The filling factor increased to ∼98% when the deposition temperature decreased to 1 °C. As the filling factor increased, the plasmon absorption intensity of Ag NR arrays was greatly enhanced, and the longitudinal surface plasmon resonance increased faster. Meanwhile, the AgNR:AAO exhibit strong photoluminescence at ∼570 nm, obviously different with that of the bare AAO at ∼495 nm. Our observation revealed the strong near-field plasmon coupling among the Ag NR arrays.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 7
    Publication Date: 2013-05-05
    Description: Background: Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatases have been implicated in a number of tumorigenesis and metastasis processes and are highly conserved. However, the understanding of PRL expression profiles during embryonic development is very limited. Results: In this study, we demonstrated and characterized the comprehensive expression pattern of Drosophila PRL, amphioxus PRL, and zebrafish PRLs during embryonic development by either whole mount immunostaining or in situ hybridization. Our results indicate that Drosophila PRL is mainly enriched in developing mid-guts and central nervous system (CNS) in embryogenesis. In amphioxus, initially PRL gene is expressed ubiquitously during early embryogenesis, but its expression become restricted to the anterior neural tube in the cerebral vesicle. In zebrafish, PRL-1 and PRL-2 share similar expression patterns, most of which are neuronal lineages. In contrast, the expression of zebrafish PRL-3 is more specific and preferential in muscle. Conclusions: This study, for the first time, elucidated the embryonic expression pattern of Drosophila, amphioxus, and zebrafish PRL genes. The shared PRL expression pattern in the developing CNS among diverse animals suggests that PRL may play conserved roles in these animals for CNS development.
    Electronic ISSN: 1471-213X
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 8
    Publication Date: 2013-06-25
    Description: Background: To compare the value of ultrasonography for diagnosing carpal tunnel syndrome (CTS) in patients with and without diabetes mellitus (DM). Methods: Eighty non-DM and 40 DM patients with electromyography-confirmed CTS were assessed and underwent high-resolution ultrasonography of the wrists. Cross-sectional area (CSA) and flattening ratio (FR) of the median nerve were measured at the carpal tunnel outlet (D) and wrist crease (W). Results: The 80 non-DM and 40 DM patients had 81 and 59 CTS-hands, respectively. The CSA_D and CSA_W were significantly larger in the CTS-hands and DM-CTS-hands compared to the normal control (p 〈 0.001). However, there is no difference of CSA_D and CSA_W between DM and non-DM CTS patients. Receiver operating characteristics [ROC] curve analysis revealed that CSA_W 〉=13 mm2 was the most powerful predictor of CTS in DM (area under curve [AUC] = 0.72; sensitivity 72.9%, specificity 61.9%) and non-DM (AUC = 0.72; sensitivity 78.5%, specificity 53.2%) patients. The CSA positively correlated with the distal motor latency of the median compound motor action potential (CMAP), distal sensory latency of the median sensory nerve action potential (SNAP), and latency of the median F wave, but negatively correlated with the amplitude of the median CMAP, amplitude of the median SNAP, and sensory NCV of the median nerve. Stepwise logistic regression revealed that CSA_W (OR 1.21, 95% CI 1.07-1.38; p = 0.003) was independently associated with CTS in DM patients and any 1 mm2 increase in CSA_W increased the rate of CTS by 28%. Conclusions: The CSA of the median nerve at the outlet and wrist crease are significantly larger in CTS hands in both DM and non-DM patients compared to normal hands. The CSA of the median nerve by ultrasonography may be a diagnostic tool for evaluating CTS in DM and non-DM patients.
    Electronic ISSN: 1471-2377
    Topics: Medicine
    Published by BioMed Central
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  • 9
    Publication Date: 2013-05-11
    Description: Background: The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza Bge., DS). This medicine is extensively used to treat cardiovascular disease. Methods: Twelve samples extracted and fractionated from SZ, DS and the formula (SZ+DS) were analyzed. The concentrations of eight phenolic compounds were determined by high performance liquid chromatography. Oxygen radical absorbance capacity (ORAC) assay and 1,1-diphenyl-2-picrylhydrazyl assay were conducted to explore the antioxidant activities of the samples and of the 15 phenolic compounds detected. Correlation analysis of the antioxidant activity of herb samples and their phenolic components was performed. Results: The main phenolic component in all SZ+DS samples was salvianolic acid B, which exhibited strong antioxidant activity (ORAC value: 16.73 +/- 2.53, IC50 value: 8.80 +/- 0.06 muM) compared with the other phenolic compounds. For all samples, there was a positive relationship between their total phenolic components and their antioxidant activities. Conclusions: Phenolic compounds were the bioactive components of the herb samples, and salvianolic acid B was identified as the main bioactive compound in the SZ+DS formula.
    Electronic ISSN: 1472-6882
    Topics: Medicine
    Published by BioMed Central
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  • 10
    Publication Date: 2012-12-13
    Description: Background: Diabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan's insurance data. Methods: We identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios (ORs) and 95% confidence intervals (CI) of esophageal cancer associated with DM, sex, age. co-morbidities and medications. Results: Cases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM (OR 0.99, 95% CI 0.71-1.37), but significantly associated with alcoholism (OR 14.1, 95% CI 7.87-25.4), esophageal ulcer (OR 10.1, 95% CI 5.70-17.9), esophageal reflux (OR 3.47, 95% CI 2.14-5.26) and uses of NSAIDs (OR 2.73, 95% CI 1.80-4.13). An elevated risk of esophageal cancer appeared in DM patients taking insulin (OR 2.57, 95% CI 1.08-6.15) or sulfonyurea (OR 3.80, 95% CI 1.16-12.5). Conclusions: Patients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.
    Electronic ISSN: 1471-230X
    Topics: Medicine
    Published by BioMed Central
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