In:
Diabetes, American Diabetes Association, Vol. 27, No. 5 ( 1978-05-01), p. 539-542
Kurzfassung:
The binding of insulin to a specific receptor on IM-9-cultured human lymphocytes was studied in vitro under conditions simulating diabetic ketoacidosis. Compared with control incubations at pH 7.4, binding was reduced by 19 per cent at pH 7.1 and by 48 per cent at pH 6.8. Addition of β-hydroxybutyrate, at concentrations similar to those seen clinically, “restored” insulin binding toward normal. We suggest that, by counteracting the effects of acidosis, ketoacids themselves maintain normal insulin-receptor binding in diabetic ketoacidosis. These data also illustrate that small molecules, present in vivo, can significantly alter the interactions between a hormone and its receptor in vitro.
Materialart:
Online-Ressource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.27.5.539
Sprache:
Englisch
Verlag:
American Diabetes Association
Publikationsdatum:
1978
ZDB Id:
1501252-9
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