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  • American Diabetes Association  (5)
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  • American Diabetes Association  (5)
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  • 1
    Online Resource
    Online Resource
    Effect of Pituitary Ablation on Diabetic Retinopathy Studied by Fluorescence Angiography
    American Diabetes Association ; 1970
    In:  Diabetes Vol. 19, No. 10 ( 1970-10-01), p. 703-714
    Details
    In: Diabetes, American Diabetes Association, Vol. 19, No. 10 ( 1970-10-01), p. 703-714
    Abstract: 1. Seventeen patients with diabetic retinopathy were studied before, and at various times following yttrium-90 implantation of the pituitary by means of fluorescence angiograms. 2. The studies demonstrated improvement in capillary abnormalities including microaneurysms, capillary dilatation and small areas of capillary nonperfusion following both partial and maximal pituitary ablation. 3. Study of microaneurysm turnover rates showed a significant de crease in the formation of new ones as compared with the rates of patients followed as controls to the pituitary implanted ones. Disappearance of existing microaneurysms was also accelerated, but this did not reach statistical significance. 4. Abnormalities in small (20–50 μ) arteries improved, while large arterial disease continued in spite of pituitary ablation. 5. New vessels often regressed but they only disappeared completely if the ablation was complete. 6. No retina returned to complete normality following pituitary ablation. 7. The most marked effect of pituitary ablation was the slowing down of the rate of formation of new microvascular lesions.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/diab.19.10.703
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 1970
    detail.hit.zdb_id: 1501252-9
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Cotton-wool Spots in Diabetic Retinopathy
    American Diabetes Association ; 1969
    In:  Diabetes Vol. 18, No. 10 ( 1969-10-01), p. 691-704
    Details
    In: Diabetes, American Diabetes Association, Vol. 18, No. 10 ( 1969-10-01), p. 691-704
    Abstract: In nineteen patients with diabetic retinopathy the appearance and life history of cotton-wool spots were studied by serial color photographs and fluorescence angiograms. Cotton-wool spots are a feature of both mild and severe diabetic retinopathy but, while their appearance is similar to that in hypertension, the associated capillary abnormalities are more severe. On fluorescence angiograms cottonwool spots are associated with arteriolar occlusion with an area of capillary closure and are surrounded by abnormal dilated capillaries. Capillary abnormalities precede the development of arteriolar occlusion which is necessary for the development of cotton-wool spots. Cotton-wool spots persist for long periods. Their mean half-life is 8.1 months in patients under forty years of age and 17.2 months in patients over the age of forty. Even when cotton-wool spots disappear, capillary closure persists. Following yttrium90 implantation of the pituitary gland the half-life of cotton-wool spots was 2.3 months.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/diab.18.10.691
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 1969
    detail.hit.zdb_id: 1501252-9
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  • 3
    Online Resource
    Online Resource
    Assimilation of D and L I-C-14 Glucose into the Retina, Brain and Other Tissues
    American Diabetes Association ; 1971
    In:  Diabetes Vol. 20, No. 8 ( 1971-08-01), p. 519-521
    Details
    In: Diabetes, American Diabetes Association, Vol. 20, No. 8 ( 1971-08-01), p. 519-521
    Abstract: Distribution of D and L l-C-14-glucose radioactivity was measured in retina, brain and other tissues by a combustion technic at short intervals following an intravenous injection in rat, rabbit and guinea pigs. Five minutes after injection, the ratios of D/L radioactivity in the retina of the three species were 23.7, 11.6 and 8.3, respectively. Similar high ratios were found in the brain but not in voluntary muscle or liver. The explanation may lie in the special characteristics of capillaries in brain and retina, which have tight intracellular junctions. Substances that enter fhe brain and retina must therefore cross the endothelial cells and cannot diffuse between them as in other tissues. The results suggest the presence of a stereospecific carrier for glucose in the endothelial cells which controls entry of glucose into the retina, as it appears to in the brain.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/diab.20.8.519
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 1971
    detail.hit.zdb_id: 1501252-9
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  • 4
    Online Resource
    Online Resource
    Reversal of Retinal Vascular Changes in Diabetes
    American Diabetes Association ; 1965
    In:  Diabetes Vol. 14, No. 3 ( 1965-03-01), p. 121-127
    Details
    In: Diabetes, American Diabetes Association, Vol. 14, No. 3 ( 1965-03-01), p. 121-127
    Abstract: Serial retinal photographs have been taken of a fourteenyear-old girl with long-standing, poorly controlled diabetes mellitus who presented with severe hypercholesterolemia. Selective fluorescence contrast photography revealed masses of dilated hairpin capillary loops in the retina. Over a period of eight months of strict diabetic control the retinal vasculature returned to normal. The findings are discussed with reference to the origin and reversibility of retinal vascular changes in diabetes.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/diab.14.3.121
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 1965
    detail.hit.zdb_id: 1501252-9
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  • 5
    Online Resource
    Online Resource
    Arterial Fluorescein Studies in Diabetic Retinopathy
    American Diabetes Association ; 1967
    In:  Diabetes Vol. 16, No. 1 ( 1967-01-01), p. 1-10
    Details
    In: Diabetes, American Diabetes Association, Vol. 16, No. 1 ( 1967-01-01), p. 1-10
    Abstract: Fifteen patients with diabetic retinopathy were studied by fluorescence angiography after injections of sodium fluorescein into the innominate artery. This method allows individual capillaries to be visualized in life and restudied at intervals. Microaneurysms were the most conspicuous feature. Many were situated on vessels at the edge of areas of capillary closure but others were located on capillaries which appeared otherwise normal. Regions of capillary closure were common and occurred even in the milder retinopathies. The areas involved ranged from about 0.1 mm. up to 5 mm. in diameter. Other capillary changes included general dilatation, shunt vessel formation and new vessel systems. Abnormalities of arterioles were seen in severe retinopathy. Three patients who had extensive destruction of the perimacular capillary bed also had occlusion of arterioles and venules surrounding the macula. These observations are discussed in relation to the pathogenesis of diabetic retinal vascular disease.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/diab.16.1.1
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 1967
    detail.hit.zdb_id: 1501252-9
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