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  • BioMed Central  (30)
  • American Chemical Society (ACS)  (17)
  • Berlin, Heidelberg :Springer Berlin / Heidelberg,  (2)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (2)
  • 1
    Online Resource
    Online Resource
    Advances in Machine Learning and Cybernetics : 4th International Conference, ICMLC 2005, Guangzhou, China, August 18-21, 2005, Revised Selected Papers. (2006)
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Details
    Keywords: Machine learning -- Congresses. ; Cybernetics -- Congresses. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (1128 pages)
    Edition: 1st ed.
    ISBN: 9783540335856
    Series Statement: Lecture Notes in Computer Science Series ; v.3930
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3067690
    DDC: 006.31
    Language: English
    Note: Intro -- Preface -- Organization -- Table of Contents -- Author Index.
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  • 2
    Online Resource
    Online Resource
    Decoding the Mechanisms of Antikythera Astronomical Device. (2015)
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Details
    Keywords: Engineering. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (286 pages)
    Edition: 1st ed.
    ISBN: 9783662484470
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4068779
    DDC: 681.111
    Language: English
    Note: Intro -- Preface -- Contents -- 1 A Sketch of Ancient Western Astronomy -- 1.1 Historical Development of Western Astronomy -- 1.1.1 Egyptian Civilization -- 1.1.2 Mesopotamian Civilization -- 1.1.3 Aegean Civilization -- 1.1.3.1 Minoan and Mycenaean Civilization -- 1.1.3.2 Dark Age -- 1.1.3.3 Classical Age -- 1.1.3.4 Ionia School -- 1.1.3.5 Pythagoras School -- 1.1.3.6 Plato School -- 1.1.3.7 Hellenistic Age -- 1.2 Astronomical Cycles and Calendars -- 1.2.1 Egyptian Calendar -- 1.2.2 Metonic Cycle -- 1.2.3 Callippic Cycle -- 1.2.4 Saros Cycle -- 1.2.5 Exeligmos Cycle -- 1.3 Ancient Astronomical Theories -- 1.3.1 Solar Theory -- 1.3.2 Lunar Theory -- 1.3.3 Planetary Theory -- 1.4 Remarks -- References -- 2 Ancient Astronomical Instruments -- 2.1 Classifications Based on Functions -- 2.1.1 Observation Application -- 2.1.2 Measuring Position and Distance Application -- 2.1.3 Measuring Time Application -- 2.1.4 Computing Application -- 2.1.5 Demonstration Application -- 2.2 Jacob's Staff -- 2.3 Astrolabe -- 2.4 Sundial -- 2.5 Calendrical Device -- 2.5.1 Astrolabe with Calendrical Gearing -- 2.5.2 Sundial with Calendrical Gearing -- 2.6 Planetarium, Astrarium, and Astronomical Clock -- 2.7 Orrery -- 2.8 Comparisons of Astronomical Instruments -- 2.9 Remarks -- References -- 3 Amazing Discovery of Archaeology -- 3.1 Origination and Process of the Discovery -- 3.1.1 Historical Background of Salvage -- 3.1.2 Story of the Antikythera Finding -- 3.2 Introduction of the Excavations -- 3.3 Known Antikythera Astronomical Device -- 3.3.1 Front Plate -- 3.3.2 Back Plate -- 3.3.3 Display Pointers -- 3.3.3.1 Axial Rotation -- 3.3.3.2 Radial Rotation -- 3.3.3.3 Axial Rotation and Radial Sliding -- 3.3.4 Interior Structure of Mechanisms -- 3.4 Relative Historical Background and Records -- 3.5 Remarks -- References -- 4 Modern Reconstruction Research. , 4.1 Early Mentions -- 4.2 Reconstruction Work by Price -- 4.3 Reconstruction Work by Edmund and Morgan -- 4.4 Reconstruction Work by Wright -- 4.5 Reconstruction Work by Freeth et al. -- 4.6 Others' Research After AD 2000 -- References -- 5 Reconstruction Design Methodology -- 5.1 Reconstruction Research -- 5.2 Reconstruction Design Methodology -- 5.2.1 Design Specifications -- 5.2.2 Generalized Chains -- 5.2.3 Specialized Chains -- 5.2.4 Reconstruction Designs -- 5.3 Historical Archives of Antikythera Device -- 5.3.1 Detected Evidence -- 5.3.2 Decoded Information -- 5.3.3 Ancient Astronomy -- 5.3.4 Ancient Astronomical Instruments -- 5.3.5 Modern Kinematic and Mechanism Analyses -- 5.4 Reconstruction Research by Yan and Lin -- 5.4.1 Concepts of Mechanical Designs -- 5.4.1.1 Mechanical Members -- Link or Kinematic Link (KL) -- Gear (KG) -- 5.4.1.2 Joints -- Revolute Joint (JR) -- Pin-in-Slot Joint (JA) -- Gear Joint () -- 5.4.1.3 Degrees of Freedom -- 5.4.1.4 Topological Structure -- 5.4.2 Date Subsystem -- 5.4.3 Eclipse Prediction Subsystem -- 5.4.4 Calendrical Subsystem -- 5.4.5 Lunar Subsystem -- 5.4.6 Solar Subsystem -- 5.4.7 Planetary Subsystem -- 5.4.8 Summary -- 5.5 Comparisons Among Different Reconstruction Researches -- 5.5.1 Comparison with Price's Design -- 5.5.2 Comparison with Edmund and Morgan's Design -- 5.5.3 Comparison with Wright's Design -- 5.5.4 Comparison with the Design of Freeth et al. -- 5.6 Remarks -- References -- 6 Reconstruction Designs of the Calendrical Subsystem -- 6.1 Historical Archives of the Calendrical Subsystem -- 6.2 Design Process of the Calendrical Subsystem -- 6.2.1 Design Specifications -- 6.2.2 Generalized Chains -- 6.2.3 Specialized Chains -- 6.2.3.1 Ground Link (Member 1) -- 6.2.3.2 Callippic Cycle Link (Member 5) -- 6.2.3.3 Olympiad Cycle Link (Member 4) -- 6.2.3.4 Input Link (Member 2). , 6.2.3.5 Metonic Cycle Link (Member 3) -- 6.2.3.6 Transmission Link (Link 6) -- 6.2.4 Reconstruction Designs -- 6.2.4.1 Tooth Calculation of the Feasible Designs -- Feasible Reconstruction Design of Fig. a -- Feasible Reconstruction Design of Fig. b -- 6.3 Remarks -- References -- 7 Reconstruction Designs of the Lunar Subsystem -- 7.1 Historical Archives of the Lunar Subsystem -- 7.1.1 Kinematic Analysis of the Lunar Theory -- 7.1.2 Kinematic Analysis of Epicyclic Gear Trains -- 7.2 Design Process of the Lunar Subsystem -- 7.2.1 Design Specifications -- 7.2.2 Generalized Chains -- 7.2.3 Specialized Chains -- 7.2.3.1 Pin-in-Slot Device (Members 3, 5, and 6, and Joint JA) -- 7.2.3.2 Anomalistic Link (Member 4) -- 7.2.3.3 Ground Link (Member 1) -- 7.2.3.4 Sidereal Link and Output Link (Members 2 and 7) -- 7.2.3.5 Revolute Joints (Joints JR) -- 7.2.3.6 Gear Joints (JG) -- 7.2.4 Reconstruction Designs -- 7.3 Remarks -- References -- 8 Reconstruction Designs of the Solar Subsystem -- 8.1 Historical Archives of the Solar Subsystem -- 8.1.1 Possible Arrangements of the Driving Power -- 8.1.2 Kinematic Analysis of the Solar Theory -- 8.1.3 Eccentric System of the Solar Motion -- 8.1.4 Epicyclic System of the Solar Motion -- 8.1.4.1 Four-Bar Mechanism with 5 Joints -- 8.1.4.2 Five-Bar Mechanism with 7 Joints -- 8.2 Design Process of the Solar Subsystem -- 8.2.1 Type 1 Design of the Solar Subsystem -- 8.2.2 Type 2 Design of the Solar Subsystem -- 8.2.3 Type 3 Design of the Solar Subsystem -- 8.2.3.1 Ground Link (Member 1) -- 8.2.3.2 Input Link (Member 2) -- 8.2.3.3 Output Link (Member 3) -- 8.2.3.4 Transmission Links (Members 4 and 5) -- 8.2.3.5 Pin-in-Slot Joint (Joint JA) -- 8.2.3.6 Revolute Joints (Joint JR) -- 8.2.3.7 Gear Joints (Joint JG) -- 8.3 Remarks -- References -- 9 Reconstruction Designs of the Planetary Subsystem. , 9.1 Historical Archives of the Planetary Subsystem -- 9.1.1 Type 1 Design: Mechanism with One Gear Joint -- 9.1.2 Type 2 Design: Mechanism with Two Gear Joints -- 9.1.2.1 All Planet Gears Are Adjacent to Each Other by a Gear Joint -- 9.1.2.2 Two Planet Gears Are Adjacent to Each Other by a Pin-in-Slot Joint -- 9.2 Design Process of the Planetary Subsystem -- 9.2.1 Type 1 Design of the Planetary Subsystem -- 9.2.2 Type 2 Design of the Planetary Subsystem -- 9.2.2.1 Ground Link (Member 1) -- 9.2.2.2 Output Link (Member 3) -- 9.2.2.3 Input Link (Member 2) -- 9.2.2.4 Transmission Links (Members 4 and 5) -- 9.2.2.5 Pin-in-Slot Joint (Joint JA) -- 9.2.2.6 Gear Joints (Joint JG) -- 9.2.2.7 Revolute Joints (Joint JR) -- 9.3 Remarks -- References -- 10 Reconstruction Designs of the Moon Phase Display Device -- 10.1 Historical Archives of the Moon Phase Display Device -- 10.1.1 Related Evidence and Available Designs -- 10.1.2 Possible Driving Power Arrangements -- 10.1.3 Possible Design Types -- 10.2 Design Process of the Moon Phase Display Device -- 10.2.1 Example 1: Ordinary Gear Trains -- 10.2.2 Example 2: Epicyclic Gear Trains with 1-DOF -- 10.2.3 Example 3: Epicyclic Gear Trains with 2-DOF -- References -- 11 Assembly Work and Models -- 11.1 Complete Interior Mechanisms -- 11.1.1 Assembly Constraints of the Lost Mechanisms -- 11.1.1.1 Driving Power of Lost Mechanisms -- 11.1.1.2 Gear Sizes -- 11.1.1.3 Types of Planets -- 11.1.1.4 Epicyclic System of Superior Planets -- 11.1.2 Assembly Work -- 11.2 3D Reconstruction Model -- 11.2.1 Tooth Calculation -- 11.2.1.1 Calendrical Subsystem -- 11.2.1.2 Solar Subsystem -- 11.2.1.3 Planetary Subsystem -- 11.2.2 Detail Designs of Gears -- 11.2.3 Space Arrangement -- 11.2.4 Simulation Model -- References -- Appendix A All 48 Feasible Designs of CompleteInterior Mechanisms -- Appendix B Detailed Design of Model 9. , Index.
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  • 3
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    Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces (2013)
    BioMed Central
    Details
    Publication Date: 2013-07-18
    Description: Background: Hyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease. Therefore, we studied the prevalence of HUA and associated risk factors in the population of two provinces in northern China. Methods: Based on the research of Chinese Physiological Constant and Health Conditions conducted in 2008--2010, we enrolled 29,639 subjects in a randomized, stratified study in four sampling areas in Heilongjiang Province and the Inner Mongolia Autonomous Region. We collected 13,140 serum samples to determine biochemical indicators including uric acid(UA), glucose, blood lipids, liver function, and renal function, and finally a representative sample of 8439 aged 18 years and older was determined. We also defined and stratified HUA, hypertension, diabetes, obesity and lipid abnormalities according to international guidelines. Results: There were significant differences in the UA levels between different genders and regions. The total prevalence of HUA is 13.7%. Men had a higher prevalence of HUA than women (21% vs. 7.9%; P 〈 0.0001). As age increased, HUA prevalence decreased in men but rose in women. The suburbs of big cities had the highest HUA prevalence (18.7%), and in high-prevalence areas the proportion of women with HUA also increased. A stepwise logistic regression model was used to filter out twelve HUA risk factors, including age, gender, residence, hypercholesterolemia, hypertriglyceridemia, impaired fasting glucose, hypertension, obesity, abdominal obesity, CKD, drinking and sleeping. After adjusting for these factors, the odds ratio of HUA was 1.92 times higher in men than in women. Compared with agricultural and pastoral areas, the odds ratio of having HUA was 2.14 for participants in the suburbs of big cities and 1.57 in the center of big cities. Conclusions: The prevalence of HUA is high in northern China. The differences in HUA prevalence by geographic region suggested that unbalanced economic development and health education, therefore HUA prevention measures should be strengthened to improve quality of life and reduce health care costs.
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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  • 4
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    Herbal compound "Songyou Yin" attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells (2013)
    BioMed Central
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    Publication Date: 2013-04-28
    Description: Background: Activated hepatic stellate cells (aHSCs) play an important role in the progression of hepatocellular carcinoma (HCC). Here, we determined if cytokines secreted in response to the herbal compound "Songyou Yin" (SYY) treatment of aHSCs could influence invasiveness and metastatic capabilities of hepatoma cells. Methods: Primary rat hepatic stellate cells (HSCs) were isolated, activated, divided into SYY treated and untreated (nSYY) groups, and conditioned media (CM-SYY and CM-nSYY, respectively) were collected. The hepatoma cell line, McA-RH7777 was cultured for 4 weeks with SYY, CM-SYY, and CM-nSYY, designated McA-SYY, McA-SYYCM and McA-nSYYCM. The invasiveness and metastatic capabilities were evaluated using Matrigel invasion assay in vitro and pulmonary metastasis in vivo. Matrix metalloproteinase-2 (MMP-2), MMP-9, E-cadherin, N-cadherin, and vimentin protein levels in McA-SYYCM and McA-nSYYCM were evaluated by Western blot. Cytokine levels in conditioned media were tested using enzyme-linked immunosorbent assay (ELISA). Results: Matrigel invasion assay indicated that the number of McA-SYYCM cells passing through the basement membrane was less than in McA-nSYYCM cells (P 〈 0.01). Similar results were also observed in vivo for lung metastasis. McA-SYYCM cells showed less pulmonary metastasis capabilities than McA-nSYYCM cells (P 〈 0.001). The reduced expression of MMP-2 and reversed epithelial to mesenchymal transition with E-cadherin upregulation, and N-cadherin and vimentin downregulation were also found in McA-SYYCM compared to McA-nSYYCM. Metastasis-promoting cytokines hepatocyte growth factor, interleukin-6, transforming growth factor-beta1, and vascular endothelial growth factor were markedly decreased in CM-SYY compared to CM-nSYY. Conclusions: SYY attenuates hepatoma cell invasiveness and metastasis capabilities through downregulating cytokines secreted by activated hepatic stellate cells.
    Electronic ISSN: 1472-6882
    Topics: Medicine
    Published by BioMed Central
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  • 5
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    RNA-seq analysis reveals the role of red light in resistance against Pseudomonas syringae pv. tomato DC3000 in tomato plants (2015)
    BioMed Central
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    Publication Date: 2015-02-28
    Description: Background: Plants attenuate their responses to a variety of bacterial and fungal pathogens, leading to higher incidences of pathogen infection at night. However, little is known about the molecular mechanism responsible for the light-induced defence response; transcriptome data would likely facilitate the elucidation of this mechanism. Results: In this study, we observed diurnal changes in tomato resistance to Pseudomonas syringae pv. tomato DC3000 (Pto DC3000), with the greatest susceptibility before midnight. Nightly light treatment, particularly red light treatment, significantly enhanced the resistance; this effect was correlated with increased salicylic acid (SA) accumulation and defence-related gene transcription. RNA-seq analysis revealed that red light induced a set of circadian rhythm-related genes involved in the phytochrome and SA-regulated resistance response. The biosynthesis and signalling pathways of multiple plant hormones (auxin, SA, jasmonate, and ethylene) were co-ordinately regulated following Pto DC3000 infection and red light, and the SA pathway was most significantly affected by red light and Pto DC3000 infection. This result indicates that SA-mediated signalling pathways are involved in red light-induced resistance to pathogens. Importantly, silencing of nonexpressor of pathogensis-related genes 1 (NPR1) partially compromised red light-induced resistance against Pto DC3000. Furthermore, sets of genes involved in redox homeostasis (respiratory burst oxidase homologue, RBOH; glutathione S-transferases, GSTs; glycosyltransferase, GTs), calcium (calmodulin, CAM; calmodulin-binding protein, CBP), and defence (polyphenol oxidase, PPO; nudix hydrolase1, NUDX1) as well as transcription factors (WRKY18, WRKY53, WRKY60, WRKY70) and cellulose synthase were differentially induced at the transcriptional level by red light in response to pathogen challenge. Conclusions: Taken together, our results suggest that there is a diurnal change in susceptibility to Pto DC3000 with greatest susceptibility in the evening. The red light induced-resistance to Pto DC3000 at night is associated with enhancement of the SA pathway, cellulose synthase, and reduced redox homeostasis.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 6
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    Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies (2015)
    BioMed Central
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    Publication Date: 2015-03-08
    Description: Background: Alcohol consumption has been inconsistently associated with the risk of ovarian cancer. The purpose of this study was to summarize the data from prospective cohort studies on the relationship between alcohol consumption and ovarian cancer using a meta-analytic approach. Methods: We performed electronic searches of PubMed, Embase, and the Cochrane Library in May 2014 to identify studies that examined the effects of alcohol consumption on the incidence of ovarian cancer. Only prospective cohort studies that reported effect estimates about the incidence of ovarian cancer with 95% confidence intervals (CIs) of alcohol intake were included. Results: Collectively, we included 13 prospective studies that reported on data from 1,996,841 individuals and included 5,857 cases of ovarian cancer. Alcohol consumption had little to no effect on ovarian cancer incidence when compared to non-drinkers (risk ratio [RR], 1.03; 95% CI, 0.96–1.10; P = 0.473). Similarly, low (RR, 0.96; 95% CI, 0.93–1.00; P = 0.059), moderate (RR, 1.08; 95% CI, 0.92–1.27; P = 0.333), and heavy (RR, 0.99; 95% CI, 0.88–1.12; P = 0.904) alcohol consumption was not associated with the risk of ovarian cancer. Furthermore, subgroup analyses suggested that low alcohol intake was associated with a reduced risk of ovarian cancer whereas heavy alcohol intake was associated with an increased risk of ovarian cancer in multiple subpopulations. Conclusions: Our study suggests that alcohol intake is not associated with an increased risk of ovarian cancer. Subgroup analyses indicated that alcohol consumption might be associated with the risk of ovarian cancer in specific population or in studies with specific characteristics.
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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  • 7
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    Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration (2015)
    BioMed Central
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    Publication Date: 2015-08-14
    Description: Background: Ductal carcinoma in situ (DCIS) is a non-obligate precursor lesion of invasive breast cancer in which approximately half the patients will progress to invasive cancer. Gaining a better understanding of DCIS progression may reduce overtreatment of patients. Expression of the pro-inflammatory cytokine interleukin-6 increases with pathological stage and grade, and is associated with poorer prognosis in breast cancer patients. Carcinoma associated fibroblasts (CAFs), which are present in the stroma of DCIS patients are known to secrete pro-inflammatory cytokines and promote tumor progression. Methods: We hypothesized that IL-6 paracrine signaling between DCIS cells and CAFs mediates DCIS proliferation and migration. To test this hypothesis, we utilized the mammary architecture and microenvironment engineering or MAME model to study the interactions between human breast CAFs and human DCIS cells in 3D over time. We specifically inhibited autocrine and paracrine IL-6 signaling to determine its contribution to early stage tumor progression. Results: Here, DCIS cells formed multicellular structures that exhibited increased proliferation and migration when cultured with CAFs. Treatment with an IL-6 neutralizing antibody inhibited growth and migration of the multicellular structures. Moreover, selective knockdown of IL-6 in CAFs, but not in DCIS cells, abrogated the migratory phenotype. Conclusion: Our results suggest that paracrine IL-6 signaling between preinvasive DCIS cells and stromal CAFs represent an important factor in the initiation of DCIS progression to invasive breast carcinoma.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 8
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    Metal Oxide-Based Selective Enrichment Combined with Stable Isotope Labeling-Mass Spectrometry Analysis for Profiling of Ribose Conjugates (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-07-01
    Description: Analytical Chemistry DOI: 10.1021/acs.analchem.5b01614
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 9
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    Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion (2015)
    BioMed Central
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    Publication Date: 2015-09-18
    Description: IntroductionThere are an estimated 60,000 new cases of ductal carcinoma in situ (DCIS) each year. A lack of understanding in DCIS pathobiology has led to overtreatment of more than half of patients. We profiled the temporal molecular changes during DCIS transition to invasive ductal carcinoma (IDC) using in vivo DCIS progression models. These studies identified B cell lymphoma-9 (BCL9) as a potential molecular driver of early invasion. BCL9 is a newly found co-activator of Wnt-stimulated β-catenin-mediated transcription. BCL9 has been shown to promote progression of multiple myeloma and colon carcinoma. However BCL9 role in breast cancer had not been previously recognized. Methods: Microarray and RNA sequencing were utilized to characterize the sequential changes in mRNA expression during DCIS invasive transition. BCL9-shRNA knockdown was performed to assess the role of BCL9 in in vivo invasion, epithelial-mesenchymal transition (EMT) and canonical Wnt-signaling. Immunofluorescence of 28 patient samples was used to assess a correlation between the expression of BCL9 and biomarkers of high risk DCIS. The cancer genome atlas data were analyzed to assess the status of BCL9 gene alterations in breast cancers. Results: Analysis of BCL9, by RNA and protein showed BCL9 up-regulation to be associated with DCIS transition to IDC. Analysis of patient DCIS revealed a significant correlation between high nuclear BCL9 and pathologic characteristics associated with DCIS recurrence: Estrogen receptor (ER) and progesterone receptor (PR) negative, high nuclear grade, and high human epidermal growth factor receptor2 (HER2). In vivo silencing of BCL9 resulted in the inhibition of DCIS invasion and reversal of EMT. Analysis of the TCGA data showed BCL9 to be altered in 26 % of breast cancers. This is a significant alteration when compared to HER2 (ERBB2) gene (19 %) and estrogen receptor (ESR1) gene (8 %). A significantly higher proportion of basal like invasive breast cancers compared to luminal breast cancers showed BCL9 amplification. Conclusion: BCL9 is a molecular driver of DCIS invasive progression and may predispose to the development of basal like invasive breast cancers. As such, BCL9 has the potential to serve as a biomarker of high risk DCIS and as a therapeutic target for prevention of IDC.
    Print ISSN: 1465-5411
    Electronic ISSN: 1465-542X
    Topics: Medicine
    Published by BioMed Central
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  • 10
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    The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue (2015)
    BioMed Central
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    Publication Date: 2015-09-18
    Description: Background: I t is established that adipose-derived stem cells (ADSCs) produce and secrete cytokines/growth factors that antagonize mucosal injury. However, the exact molecular basis underlying the treatment effects exerted by ADSCs is ill understood, and whether ADSCs cooperate with adipose tissue particles to improve mucosal function in patients with empty nose syndrome (ENS) has not been explored. We investigated the impact of ADSCs on nasal mucosa, the associated mechanisms, and their use in the treatment of patients with ENS. Results: The nasal endoscope and mucociliary clearance assessments were significantly improved (P 
    Electronic ISSN: 2045-3701
    Topics: Biology
    Published by BioMed Central
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