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  • Wiley-Blackwell  (3)
  • American Chemical Society  (1)
  • American Institute of Physics (AIP)  (1)
  • Institute of Physics (IOP)  (1)
  • The American Association for Cancer Research (AACR)  (1)
Publikationsart
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Erscheinungszeitraum
  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 6763-6772 
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2016-11-16
    Beschreibung: DArk Matter Particle Explorer (DAMPE) is the first Chinese astronomical satellite, successfully launched on Dec. 17 2015. As the most important payload of DAMPE, the BGO calorimeter contains 308 bismuth germanate crystals, with 616 photomultiplier tubes, one coupled to each end of every crystal. Environmental tests have been carried out to explore the environmental adaptability of the flight model of the BGO calorimeter. In this work we report the results of the vibration tests. During the vibration tests, no visible damage occurred in the mechanical assembly. After random or sinusoidal vibrations, the change of the first order natural frequency of BGO calorimeter during the modal surveys is less than 5%. The shift ratio of Most Probable Value of MIPs changes in cosmic-ray tests are shown, the mean value of which is about −4%. The comparison of results of cosmic-ray tests before and after the vibration shows no significant change in the performance of the BGO calorimeter. All th...
    Print ISSN: 1674-1137
    Thema: Physik
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Publikationsdatum: 2017-10-10
    Beschreibung: Lymph node (LN) metastasis is commonly associated with systemic distant organ metastasis in human breast cancer and is an important prognostic predictor for survival of breast cancer patients. However, whether tumor-draining LNs (TDLNs) play a significant role in modulating the malignancy of cancer cells for distant metastasis remains controversial. Using a syngeneic mouse mammary tumor model, we found that breast tumor cells derived from TDLN have higher malignancy and removal of TDLNs significantly reduced distant metastasis. Up-regulation of oncogenic Il-17rb in cancer cells derived from TDLNs contributes to their malignancy. TGF-β1 secreted from regulatory T cells (Tregs) in the TDLNs mediated the up-regulation of Il-17rb through downstream Smad2/3/4 signaling. These phenotypes can be abolished by TGF-β1 neutralization or depletion of Tregs. Consistently, clinical data showed that the up-regulation of IL-17RB in cancer cells from LN metastases correlated with the increased prevalence of Tregs as well as the aggressive growth of tumors in mouse xenograft assay. Together, these results indicate that Tregs in TDLNs play an important role in modulating the malignancy of breast cancer cells for distant metastasis. Blocking IL-17RB expression could therefore be a potential approach to curb the process. Treg-secreted TGF-β1 in the tumor-draining LN (TDLN) microenvironment up-regulates IL-17RB expression in breast cancer cells, thereby enhancing their metastatic potential.
    Print ISSN: 1757-4676
    Digitale ISSN: 1757-4684
    Thema: Medizin
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Publikationsdatum: 2018-08-16
    Beschreibung: Src homology region 2 (SH2) domain–containing phosphatase 1 (SHP-1, also known as PTPN6) is a nonreceptor protein tyrosine phosphatase that acts as a negative regulator of inflammation. Emerging evidence indicates that SHP-1 plays a role in inhibiting the progression of hepatocellular carcinoma (HCC). However, the role of SHP-1 in hepatocarcinogenesis remains unknown. Here, we find that levels of SHP-1 are significantly downregulated in human HCC tissues compared with those in noncancerous tissues (P 〈 0.001) and inversely correlate with tumor diameters (r = −0.4130, P = 0.0002) and serum α-fetoprotein levels (P = 0.047). Reduced SHP-1 expression was associated with shorter overall survival of patients with HCC with HBV infection. Overexpression of SHP-1 suppressed proliferation, migration, invasion, and tumorigenicity of HCC cells, whereas knockdown of SHP-1 enhanced the malignant phenotype. Moreover, knockout of Ptpn6 in hepatocytes (Ptpn6HKO) enhanced hepatocarcinogenesis induced by diethylnitrosamine (DEN) as well as metastasis of primary liver cancer in mice. Furthermore, systemic delivery of SHP-1 by an adenovirus expression vector exerted a therapeutic effect in an orthotopic model of HCC in NOD/SCID mice and DEN-induced primary liver cancers in Ptpn6HKO mice. In addition, SHP-1 inhibited the activation of JAK/STAT, NF-κB, and AKT signaling pathways, but not the MAPK pathway in primary hepatocytes from DEN-treated mice and human HCC cells. Together, our data implicate SHP-1 as a tumor suppressor of hepatocarcinogenesis and HCC progression and propose it as a novel prognostic biomarker and therapeutic target of HCC.Significance: The nonreceptor protein tyrosine phosphatase SHP-1 acts as a tumor suppressor in hepatocellular carcinoma. Cancer Res; 78(16); 4680–91. ©2018 AACR.
    Print ISSN: 0008-5472
    Digitale ISSN: 1538-7445
    Thema: Medizin
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Publikationsdatum: 2014-09-12
    Beschreibung: It is challenging to investigate the magnetic anisotropy of Fe/Si(001) film in the case a limited magnetic field strength, when both coherent rotation and domain wall displacement coexist in the magnetization reversal process. Owing to the domain wall displacement, the magnetization reversal switching field is far lower than the magnetic anisotropy field, and, consequently, only the magnetization reversal process near easy axis can be treated as coherent rotation. Here, we record the slope of the magnetic torque curve of an iron film grown on a Si(001) substrate measured near the easy axis by anisotropic magnetoresistance (AMR) to separate the coherent rotation of magnetization reversal process from domain wall displacement. Furthermore, the magnitudes of various magnetic anisotropy constants were derived from the magnetic torque curves. Our work suggests that the AMR at low fields can clearly separate the detailed contributions of various magnetic anisotropies when domain wall displacement existed in Fe(001) ultrathin film. We also report on the hysteresis behavior of such films as measured by magneto-optic Kerr effect.
    Print ISSN: 0003-6951
    Digitale ISSN: 1077-3118
    Thema: Physik
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Publikationsdatum: 2017-02-16
    Beschreibung: A series of confirmed and suspected dammed palaeo-lake sedimentary successions is scattered within the middle Yarlung Tsangpo valley in Tibet. However, the chronology, the genesis of the dam and its location, the water level of the dammed lake, the process of dam failure and the spatiotemporal relationships between the sedimentary successions remain controversial. Here, we focus on one sedimentary succession of the suspected dammed palaeo-lake at Xigazê. We measured the grain-size distribution, magnetic susceptibility, organic and inorganic carbon content, and δ 13 C org and δ 15 N total ratios of the sediments. In addition, we measured the δ 18 O shell and δ 13 C shell values of modern and fossil Radix sp. shells, and the δ 18 O water and δ 13 C DIC values of the ambient water with different hydrological regimes. The results indicate that the δ 18 O shell values of modern Radix sp. and the δ 18 O water of the ambient water body significantly depend on its hydrological status. In addition, a strong positive relationship was observed between δ 18 O shell values of modern Radix sp. shells and the δ 18 O water of the ambient water on the Tibetan Plateau. According to this correlation, the δ 18 O water values of the palaeo-water body are reconstructed using the δ 18 O shell values of Radix sp. fossil shells in the Xigazê section. Further, based on the δ 18 O shell values of fossil Radix sp., the reconstructed δ 18 O water of the palaeo-water body and the specific habitats of Radix sp., we infer that the sedimentary succession in the Xigazê broad valley was mainly formed within the backwater terminal zone of a dammed palaeo-lake and that the elevation of the water level of the lake was approximately 3811 m a.s.l. AMS 14 C dating indicates that the deposits of the dammed palaeo-lake were formed at about 33–22 cal. ka BP. Finally, the presence of Radix sp. fossil shells within the Xigazê section suggests that Radix sp. survived the late Last Glacial Period on the Tibetan Plateau.
    Print ISSN: 0300-9483
    Digitale ISSN: 1502-3885
    Thema: Geographie , Geologie und Paläontologie
    Publiziert von Wiley-Blackwell
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Publikationsdatum: 2013-02-19
    Beschreibung: A multi-drug resistant Escherichia coli C21 was isolated from a chicken in China. It was shown to be positive for the presence of the bla TEM-1 , bla CTX-M-55 and rmtB genes by PCR. This strain was examined by phylogenetic grouping, conjugation experiments, plasmid analysis, PCR-based replicon typing and multi-locus sequence typed (MLST). The genetic environment of bla CTX-M-55 was investigated by PCR mapping. The strain belonged to phylogroup A, ST156. The bla CTX-M-55 and rmtB genes were found to be present in separate plasmids that belonged to the IncI1 and IncN families, respectively. These antibiotic-resistant plasmids could be transferred to the recipient strain alone or together. A new arrangement of IS Ecp1 Δ-IS 1294- ΔIS Ecp1-bla CTX-M-55 -ORF 477 , in which the IS Ecp1 element was disrupted by another IS 1294 element, was identified initially. Conjugative transfer and IS elements found in this study could lead to the rapid dissemination of bla CTX-M-55 and rmtB among strains of Enterobacteriaceae , which could pose a threat to animal husbandry and public health.
    Print ISSN: 0233-111X
    Digitale ISSN: 1521-4028
    Thema: Biologie
    Publiziert von Wiley-Blackwell
    Standort Signatur Einschränkungen Verfügbarkeit
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