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  • American Association for the Advancement of Science (AAAS)  (8)
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  • American Association for the Advancement of Science (AAAS)  (8)
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  • 1
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2022
    In:  Science Advances Vol. 8, No. 34 ( 2022-08-26)
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 8, No. 34 ( 2022-08-26)
    Abstract: A soft-robotic ciliated epidermis achieves reconfigurable coordinated fluid manipulation on various three-dimensional surfaces.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2022
    detail.hit.zdb_id: 2810933-8
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  • 2
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2021
    In:  Science Robotics Vol. 6, No. 53 ( 2021-04-28)
    In: Science Robotics, American Association for the Advancement of Science (AAAS), Vol. 6, No. 53 ( 2021-04-28)
    Abstract: Small-scale soft-bodied machines that respond to externally applied magnetic field have attracted wide research interest because of their unique capabilities and promising potential in a variety of fields, especially for biomedical applications. When the size of such machines approach the sub-millimeter scale, their designs and functionalities are severely constrained by the available fabrication methods, which only work with limited materials, geometries, and magnetization profiles. To free such constraints, here, we propose a bottom-up assembly-based 3D microfabrication approach to create complex 3D miniature wireless magnetic soft machines at the milli- and sub-millimeter scale with arbitrary multimaterial compositions, arbitrary 3D geometries, and arbitrary programmable 3D magnetization profiles at high spatial resolution. This approach helps us concurrently realize diverse characteristics on the machines, including programmable shape morphing, negative Poisson’s ratio, complex stiffness distribution, directional joint bending, and remagnetization for shape reconfiguration. It enlarges the design space and enables biomedical device-related functionalities that are previously difficult to achieve, including peristaltic pumping of biological fluids and transport of solid objects, active targeted cargo transport and delivery, liquid biopsy, and reversible surface anchoring in tortuous tubular environments withstanding fluid flows, all at the sub-millimeter scale. This work improves the achievable complexity of 3D magnetic soft machines and boosts their future capabilities for applications in robotics and biomedical engineering.
    Type of Medium: Online Resource
    ISSN: 2470-9476
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2021
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  • 3
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 6, No. 9 ( 2020-02-28)
    Abstract: Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant chemotherapy is underutilized in gastric cancer management, because of the lack of biomarkers for patient selection and a limited understanding of resistance mechanisms. Here, we performed whole-genome, whole-exome, and RNA sequencing on 84 clinical samples (including matched pre- and posttreatment tumors) from 35 patients whose responses to neoadjuvant chemotherapy were rigorously defined. We observed increased microsatellite instability and mutation burden in nonresponse tumors. Through comparisons of response versus nonresponse tumors and pre- versus posttreatment samples, we found that C10orf71 mutations were associated with treatment resistance, which was supported by drug response data and potentially through inhibition of cell cycle, and that MYC amplification correlated with treatment sensitivity, whereas MDM2 amplification showed the opposite pattern. Neoadjuvant chemotherapy also reshapes tumor-immune signaling and microenvironment. Our study provides a critical basis for developing precision neoadjuvant regimens.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2020
    detail.hit.zdb_id: 2810933-8
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  • 4
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2019
    In:  Science Advances Vol. 5, No. 8 ( 2019-08-02)
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 5, No. 8 ( 2019-08-02)
    Abstract: Organic-inorganic hybrid halide perovskites are emerging as promising materials for next-generation light-emitting diodes (LEDs). However, the poor stability of these materials has been the main obstacle challenging their application. Here, we performed first-principles calculations, revealing that the molecule dissociation energy of Dion-Jacobson (DJ) structure using 1,4-bis(aminomethyl)benzene molecules as bridging ligands is two times higher than the typical Ruddlesden-Popper (RP) structure based on phenylethylammonium ligands. Accordingly, LEDs based on the DJ structure show a half-lifetime over 100 hours, which is almost two orders of magnitude longer compared with those based on RP structural quasi–two-dimensional perovskite. To the best of our knowledge, this is the longest lifetime reported for all organic-inorganic hybrid perovskites operating at the current density, giving the highest external quantum efficiency (EQE) value. In situ tracking of the film composition in operation indicates that the DJ structure was maintained well after continuous operation under an electric field.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    detail.hit.zdb_id: 2810933-8
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  • 5
    In: Energy Material Advances, American Association for the Advancement of Science (AAAS), Vol. 4 ( 2023-01)
    Abstract: Green production of functional nano-oxides on a large scale is crucial for the modern manufacturing industries. Traditional hydrothermal methods and ball milling are usually time-consuming and require long-term energy input with undesired by-products. Herein, an ultrafast laser-induced high-pressure photochemistry manufacturing technique is developed to massively produce planar-aligned graphene-coated two-dimensional (2D) SnO 2 nanoplatelet on carbon nanotube (CNT) paper under the green chemistry guidelines. The unique design of Z-axis confinement added to the ultrafast laser irradiation provides an exceptional high temperature of 1772 K and a high pressure of 24 GPa in the localized laser plasma plume. This transient nonequilibrium condition controls the formation of 2D SnO 2, and the ablated C atoms cool down afterward as in-situ “glue” to intactly seal the oxides on the CNT substrate. The resultant hierarchical Graphene@2D SnO 2 @CNT paper anode for Li-ion battery has an outstanding capacity of 819 mAh g −1 (1637 mAh cm −3 ) at 0.5 A g −1 and retains 622 mAh g −1 (1245 mAh cm −3 ) at 5.0 A g −1 . The high capacity at 0.5 A g −1 has a retention of 92% after 600 cycles. This work provides an environmental-friendly scalable manufacturing technique to produce functional nanocomposites in 1 step.
    Type of Medium: Online Resource
    ISSN: 2692-7640
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2023
    detail.hit.zdb_id: 3072998-1
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  • 6
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2021
    In:  Science Advances Vol. 7, No. 27 ( 2021-07-02)
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 7, No. 27 ( 2021-07-02)
    Abstract: Soft-bodied locomotion in fluid-filled confined spaces is critical for future wireless medical robots operating inside vessels, tubes, channels, and cavities of the human body, which are filled with stagnant or flowing biological fluids. However, the active soft-bodied locomotion is challenging to achieve when the robot size is comparable with the cross-sectional dimension of these confined spaces. Here, we propose various control and performance enhancement strategies to let the sheet-shaped soft millirobots achieve multimodal locomotion, including rolling, undulatory crawling, undulatory swimming, and helical surface crawling depending on different fluid-filled confined environments. With these locomotion modes, the sheet-shaped soft robot can navigate through straight or bent gaps with varying sizes, tortuous channels, and tubes with a flowing fluid inside. Such soft robot design along with its control and performance enhancement strategies are promising to be applied in future wireless soft medical robots inside various fluid-filled tight regions of the human body.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2021
    detail.hit.zdb_id: 2810933-8
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  • 7
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2022
    In:  Ecosystem Health and Sustainability Vol. 8, No. 1 ( 2022-12-31)
    In: Ecosystem Health and Sustainability, American Association for the Advancement of Science (AAAS), Vol. 8, No. 1 ( 2022-12-31)
    Abstract: Wetlands account for up to 70% of the natural source of methane (CH 4 ) in terrestrial ecosystems on a global scale. Soil microbes are the ultimate producers and biological consumers of CH 4 in wetlands. Therefore, simulating microbial mechanisms of CH 4 production and consumptionwould improve the predictability of CH 4 flux in wetland ecosystems. In this study, we applied a microbial-explicit model, the CLM-Microbe, to simulate CH 4 flux in three major natural wetlands in northeastern China. The CLM-Microbe model was able to capture the seasonal variation of gross primary productivity (GPP), dissolved organic carbon (DOC), and CH 4 flux. The CLM-Microbe model explained more than 40% of the variation in GPP and CH 4 flux across sites. Marsh wetlands had higher CH 4 flux than mountain peatlands. Ebullition dominated the CH 4 transport pathway in all three wetlands. The methanogenesis dominates while methanotroph makes a minor contribution to the CH 4 flux, making all wetlands a CH 4 source. Sensitivity analysis indicated that microbial growth and death rates are the key factors governing CH 4 emission and vegetation physiological properties ( flnr ) and maintenance respiration predominate GPP variation. Explicitly simulating microbial processes allows genomic information to be incorporated, laying a foundation for better predicting CH 4 dynamics under the changing environment.
    Type of Medium: Online Resource
    ISSN: 2096-4129 , 2332-8878
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2022
    detail.hit.zdb_id: 2815489-7
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  • 8
    Online Resource
    Online Resource
    American Association for the Advancement of Science (AAAS) ; 2023
    In:  Ecosystem Health and Sustainability
    In: Ecosystem Health and Sustainability, American Association for the Advancement of Science (AAAS)
    Type of Medium: Online Resource
    ISSN: 2332-8878
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2023
    detail.hit.zdb_id: 2815489-7
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