In:
Science, American Association for the Advancement of Science (AAAS), Vol. 376, No. 6594 ( 2022-05-13), p. 695-696
Abstract:
Our understanding of how cells form distinct tissues and organs and interact with each other is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the landscapes of individual cell types, along with their abundance and interactions, in homeostasis and diseased conditions ( 1 – 5 ), but these studies are often limited to a single organ. A systematic comparison of cell types across different tissues is needed to understand shared and variable transcriptional features and how these specializations are important for organ function. On pages 711, 712, and 713 of this issue, The Tabula Sapiens Consortium ( 6 ), Eraslan et al. ( 7 ), and Domínguez Conde et al. ( 8 ), respectively, as well as Suo et al. ( 9 ), report pan-tissue single-cell transcriptome atlases covering more than a million cells, including 500 cell types, across more than 30 human tissues from 68 donors. These four studies apply rigorous ontologies to consistently annotate and compare single cells between organs.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.abq2116
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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