In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 630 ( 2022-02-02)
Abstract:
Improving early detection of lung cancer is key to improving outcomes. On the basis of their exploratory single-cell RNA sequencing suggesting dysregulated lipid metabolism in early lung cancer tissue, Wang et al . performed lung plasma lipidomic profiling and found that nine lipids were commonly dysregulated in patients with early-stage lung tumors. The authors validated the ability of these nine lipids to detect early-stage cancer across multiple independent cohorts largely composed of nonsmokers with stage I adenocarcinomas, as compared with healthy individuals or individuals with benign tumors. This study shows promise for the clinical detection of early-stage lung cancer in patients.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abk2756
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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