In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 688 ( 2023-03-22)
Abstract:
Musculoskeletal tissue engineering approaches require a reliable source of precursor cells. Hochmann et al . report that despite having some transcriptional similarities, the inherent differentiation potential of different stromal cell types is constrained by their enhancer landscapes. In contrast to stromal cells derived from white adipose tissue or umbilical cord, only bone marrow–derived cells had an epigenetic signature permitting their differentiation into functional hypertrophic cartilage discs capable of ameliorating a critical-size bone defect model after transplantation into mice. These findings have ramifications for the development of regenerative cell–based musculoskeletal therapies. —CAC
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abm7477
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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