In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 659 ( 2022-08-24)
Abstract:
Although some of the symptoms of Alzheimer’s disease (AD) are conserved among patients, multiple phenotypes exist, including amnestic, visuospatial, language, and behavioral/dysexecutive. Understanding the mechanisms mediating the different behavioral phenotypes will help the development of specific treatments. Here, Therriault and colleagues studied the pattern of tau pathology spreading in multiple cohorts of patients with different phenotypes and showed that each phenotype was associated with a specific connectivity-based pattern of tau aggregation. The results suggest that intrinsic brain connectivity drives tau aggregation pattern, thus determining the behavioral phenotype of the disease.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abc8693
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
Permalink