In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 641 ( 2022-04-20)
Abstract:
Synthetic scaffolds are an attractive option for dressings to treat skin wounds because they are shelf stable, have tunable and defined chemical compositions, and are more affordable than naturally derived scaffolds or cell-based dermal substitutes. Here, Patil and colleagues investigated the role of scaffold hydrophilicity in polythioketal-based polyurethane (PTK-UR) foam scaffold resorption and promotion of tissue regeneration in wound healing. They found that hydrophilic scaffolds with seven ethylene glycol units between the thioketal bonds in the polymer backbone exhibited optimal reactive oxygen species–dependent degradation and porcine skin wound healing, including ischemic flap excisional wounds. Results support further investigation of PTK-UR formulations as alternatives to commercially available wound matrices.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abm6586
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
Permalink