In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 691 ( 2023-04-12)
Abstract:
Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV, respectively) are mosquito-borne alphaviruses that can cause severe neurological and systemic disease in humans and equids. There is no approved vaccine or therapeutic available to treat human alphavirus infections. Cao et al . now describe the identification and optimization of a quinazolinone, BDGR-49, that showed potent antiviral activity against VEEV and EEEV in vitro and outstanding prophylactic and therapeutic efficacy in mouse models of VEEV and EEEV. BDGR-49 also showed promising pharmacokinetic profiles and evidence of brain penetration. Together these findings highlight BDGR-49 as a promising compound for treating encephalitic alphavirus infection. —CF
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abl9344
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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