In:
Science Advances, American Association for the Advancement of Science (AAAS), Vol. 6, No. 44 ( 2020-10-30)
Abstract:
Aberrant number and/or dysfunction of CD4 + Foxp3 + Regulatory T cells (T regs ) are associated with the pathogenesis of rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural T regs (nT regs ) prefer to accumulate in inflamed joints and transdifferentiate to T H 17 cells under the stimulation of inflamed synovial fibroblasts (SFs). In this study, we made a head-to-head comparison of both T reg subsets and demonstrated that induced T regs (iT regs ), but not nT regs , retained Foxp3 expression and regulatory function on T effector cells (T effs ) after being primed with inflamed SFs. In addition, iT regs inhibited proliferation, inflammatory cytokine production, migration, and invasion ability of collagen-induced arthritis (CIA)–SFs in vitro and in vivo. Moreover, we noted that iT regs directly targeted inflamed SFs to treat autoimmune arthritis, while nT regs failed to do this. Thus, manipulation of the iT reg subset may have a greater potential for prevention or treatment of patients with RA.
Type of Medium:
Online Resource
ISSN:
2375-2548
DOI:
10.1126/sciadv.abb0606
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2020
detail.hit.zdb_id:
2810933-8
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