In:
Science, American Association for the Advancement of Science (AAAS), Vol. 287, No. 5461 ( 2000-03-24), p. 2274-2277
Abstract:
Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX 3 CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX 3 CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX 3 CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX 3 CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.287.5461.2274
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2000
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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