In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 8, No. 87 ( 2023-09-29)
Abstract:
Organelle cross-talk plays a fundamental role in cell biology, but how this cross-talk controls tumor-infiltrating CD8 + T cells (TILs) is not understood. Yang et al . investigate the role of MFN2 in CD8 + TILs, identifying that mitochondrial interaction with the endoplasmic reticulum (ER) is required for metabolic fitness and antitumor activity. Through interaction with SERCA2 on the ER, MFN2 was required for mitochondria-ER contact and Ca 2+ homeostasis. MFN2 expression was associated with better survival in patients with cancer, and promoting MFN2 expression in CD8 + T cells improved response to immune checkpoint blockade in mice. Together, these findings identify a critical role for MFN2 in regulating the metabolism, function, and survival of CD8 + T cells and suggest that boosting MFN2 expression is an attractive avenue for improving immunotherapy. —Hannah Isles
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abq2424
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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