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  • American Association for the Advancement of Science (AAAS)  (2)
  • 1
    Online Resource
    Online Resource
    Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
    American Association for the Advancement of Science (AAAS) ; 2004
    In:  Science Vol. 303, No. 5657 ( 2004-01-23), p. 531-534
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 303, No. 5657 ( 2004-01-23), p. 531-534
    Abstract: What are the components that control the assembly of subcellular organelles in eukaryotic cells? Although membranes can clearly be distorted by cytosolic factors, very little is known about the intrinsic mechanisms that control the biogenesis, shape, and organization of organellar membranes. Here, we found that the unconventional phospholipid lysobisphosphatidic acid (LBPA) could induce the formation of multivesicular liposomes that resembled the multivesicular endosomes that exist where this lipid is found in vivo. This process depended on the same pH gradient that exists across endosome membranes in vivo and was selectively controlled by Alix. In turn, Alix regulated the organization of LBPA-containing endosomes in vivo.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1092425
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2004
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Regulation of the EGF Transcriptional Response by Endocytic Sorting
    American Association for the Advancement of Science (AAAS) ; 2012
    In:  Science Signaling Vol. 5, No. 215 ( 2012-03-13)
    Details
    In: Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 5, No. 215 ( 2012-03-13)
    Abstract: Ligand binding to the epidermal growth factor receptor (EGFR) on the cell surface activates the extracellular signal–regulated kinase (ERK) cascade. Activated, ligand-bound receptors are internalized, and this process may contribute to termination of signaling or enable signaling from intracellular sites. ESCRT (endosomal sorting complex required for transport) complexes may contribute to termination of signaling by sorting receptors into intraluminal vesicles of multivesicular endosomes from which the receptors continue into lysosomes for degradation. We showed that depletion of ESCRTs, which causes the retention of the EGFR in endosomes, increased the activation of the EGFR and its downstream kinases but had little effect on the overall profile and amplitude of the EGF-induced transcriptional response. In contrast, interfering with receptor endocytosis or ubiquitination to keep the EGFR at the cell surface stimulated increases in the abundance of many EGF-induced transcripts, similar to those induced by EGFR overexpression. We also found that the complete EGF transcriptional program was rapidly activated after ligand binding to the receptor. We conclude that the transcriptional response is elicited primarily by receptor molecules at the cell surface.
    Type of Medium: Online Resource
    ISSN: 1945-0877 , 1937-9145
    URL: Article
    DOI: 10.1126/scisignal.2002351
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2012
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