In:
Science, American Association for the Advancement of Science (AAAS), Vol. 369, No. 6501 ( 2020-07-17), p. 250-251
Abstract:
Numerous cancer types can metastasize to a remote and inhospitable part of the human central nervous system (CNS): the subarachnoid or leptomeningeal space. This covers the surface of the nervous system and contains the cerebrospinal fluid (CSF). The CSF is largely hypocellular in healthy humans and has limited metabolic resources. It provides protective buoyancy for the brain and permits circulation of micronutrients and growth factors in the ventricular system. The CSF constitutes a relatively accessible proxy of the health of the CNS, and it is routinely sampled by physicians through a lumbar puncture. On page 276 of this issue, Chi et al. ( 1 ) reveal how human cancer cells thrive in this specialized anatomical location by hijacking a high-affinity iron transport system. This work highlights how studying tumor cell properties in the context of the challenges posed by the microenvironment can reveal unknown biology and possible approaches to therapy.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.abb7041
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2020
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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