In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 9, No. 401 ( 2017-08-02)
Abstract:
Allergen-specific type 2 helper T (T H 2) cells play a central role in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. One major factor limiting the use of such atopic disease–causing T cells as both therapeutic targets and clinically useful biomarkers is the lack of an accepted methodology to identify and differentiate these cells from overall nonpathogenic T H 2 cell types. We have described a subset of human memory T H 2 cells confined to atopic individuals that includes all allergen-specific T H 2 cells. These cells are terminally differentiated CD4 + T cells (CD27 − and CD45RB − ) characterized by coexpression of CRT H 2, CD49d, and CD161 and exhibit numerous functional attributes distinct from conventional T H 2 cells. Hence, we have denoted these cells with this stable allergic disease–related phenotype as the T H 2A cell subset. Transcriptome analysis further revealed a distinct pathway in the initiation of pathogenic responses to allergen, and elimination of these cells is indicative of clinical responses induced by immunotherapy. Together, these findings identify a human T H 2 cell signature in allergic diseases that could be used for response-monitoring and designing appropriate immunomodulatory strategies.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.aam9171
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2017
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