In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 712 ( 2023-09-06)
Abstract:
Chronic kidney disease (CKD) is associated with increased vascular calcification, but the underlying mechanisms are poorly understood. Here, Amaya-Garrido and colleagues performed a proteomic analysis on two cohorts of patients, one with stage 3-4 CKD and one with stage 5 CKD on dialysis, finding that increased calprotectin was associated with increased risk of CV complications and mortality. In a 5/6 nephrectomy mouse model of CKD on a high-phosphate diet, administration of the calprotectin inhibitor paquinimod could prevent increased vascular calcification without affecting renal function or calprotectin abundance, with similar findings observed after treatment of aged apolipoprotein E–deficient mice on a high-phosphate diet. These findings suggest that inhibition of calprotectin might help to prevent vascular calcification in high-risk patients. —Melissa Norton
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abn5939
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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