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  • Woods Hole Oceanographic Institution  (2)
  • American Association for the Advancement of Science (AAAS)  (1)
  • 1
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    Tables and graphs of measurements made across four Cape Cod beaches 1957-1958 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-26
    Description: Originally issued as Reference No. 61-4, series later renamed WHOI-.
    Description: The primary purpose of this report is to present tables of measurements made across four Cape Cod beaches.
    Description: The field work was supported entirely by the Geography Branch of the Office of Naval Research under contract number Nonr-1254 (00) (NR-388 - 018).
    Keywords: Beaches
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
    Format: application/pdf
    Location Call Number Limitation Availability
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    PAPER (OA)
  • 2
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    Erosion of the cliffs of Outer Cape Cod : tables and graphs (2014)
    Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-26
    Description: Originally issued as Reference No. 64-21, series later renamed WHOI-.
    Description: The following tables and graphs place in convenient storage the results of several years of careful surveying and at the same time provide rudimentary interpretation of resuIts by comparing erosion rates. The reader will find listed in the bibliography pertinent published papers which analyze these coastal erosion data in great detail.
    Description: This work has been supported by the Geography Branch of the Office of Naval Research, Contract Number Nonr 1254 (00), (NR-388-018), and by Nonr 2196 (00).
    Keywords: Erosion ; Coast changes
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
    Format: application/pdf
    Location Call Number Limitation Availability
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    PAPER (OA)
  • 3
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    Facile profiling of molecular heterogeneity by microfluidic digital melt (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-09-27
    Description: This work presents a digital microfluidic platform called HYPER-Melt (high-density profiling and enumeration by melt) for highly parallelized copy-by-copy DNA molecular profiling. HYPER-Melt provides a facile means of detecting and assessing sequence variations of thousands of individual DNA molecules through digitization in a nanowell microchip array, allowing amplification and interrogation of individual template molecules by detecting HRM fluorescence changes due to sequence-dependent denaturation. As a model application, HYPER-Melt is used here for the detection and assessment of intermolecular heterogeneity of DNA methylation within the promoters of classical tumor suppressor genes. The capabilities of this platform are validated through serial dilutions of mixed epialleles, with demonstrated detection limits as low as 1 methylated variant in 2 million unmethylated templates (0.00005%) of a classic tumor suppressor gene, CDKN2A (p14 ARF ). The clinical potential of the platform is demonstrated using a digital assay for NDRG4 , a tumor suppressor gene that is commonly methylated in colorectal cancer, in liquid biopsies of healthy and colorectal cancer patients. Overall, the platform provides the depth of information, simplicity of use, and single-molecule sensitivity necessary for rapid assessment of intermolecular variation contributing to genetic and epigenetic heterogeneity for challenging applications in embryogenesis, carcinogenesis, and rare biomarker detection.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
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