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  • Nature Publishing Group (NPG)  (15)
  • American Association for the Advancement of Science (AAAS)  (4)
  • 1
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    Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-03-15
    Description: In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from animals that are at key sites in vertebrate evolution. Although the estrogen receptor [ER] appears to be the ancestral vertebrate steroid receptor and estradiol [E2] is the physiological ligand for vertebrate ERs, the identity of the ancestral ligand(s) for the ER remains unknown. Here, using an analysis of crystal structures of human ERα with E2 and other chemicals and 3D models of human ERα with 27-hydroxycholesterol and 5-androsten-3β,17β-diol, we propose that one or more Δ5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. The evidence that chemicals with a β-hydroxy at C3 in a saturated A ring can act as estrogens and the conformational flexibility of the vertebrate ER can explain the diversity of synthetic chemicals that disrupt estrogen responses by binding to vertebrate ERs.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 2
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    Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-03-15
    Description: In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from animals that are at key sites in vertebrate evolution. Although the estrogen receptor [ER] appears to be the ancestral vertebrate steroid receptor and estradiol [E2] is the physiological ligand for vertebrate ERs, the identity of the ancestral ligand(s) for the ER remains unknown. Here, using an analysis of crystal structures of human ERα with E2 and other chemicals and 3D models of human ERα with 27-hydroxycholesterol and 5-androsten-3β,17β-diol, we propose that one or more Δ5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. The evidence that chemicals with a β-hydroxy at C3 in a saturated A ring can act as estrogens and the conformational flexibility of the vertebrate ER can explain the diversity of synthetic chemicals that disrupt estrogen responses by binding to vertebrate ERs.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 3
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    Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma (2013)
    Nature Publishing Group (NPG)
    In: Oncogene
    Details
    Publication Date: 2013-09-27
    Description: Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma Oncogene 32, 4664 (26 September 2013). doi:10.1038/onc.2012.487 Authors: K Thompson-Wicking, R W Francis, A Stirnweiss, E Ferrari, M D Welch, E Baker, A R Murch, A M Gout, K W Carter, A K Charles, M B Phillips, U R Kees & A H Beesley
    Keywords: BRD4NUTcarcinomaNMCRNA-Seqtranscriptome
    Print ISSN: 0950-9232
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 4
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    Assessing the role of spatial correlations during collective cell spreading (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-07-17
    Description: Spreading cell fronts are essential features of development, repair and disease processes. Many mathematical models used to describe the motion of cell fronts, such as Fisher's equation, invoke a mean–field assumption which implies that there is no spatial structure, such as cell clustering, present. Here, we examine the presence of spatial structure using a combination of in vitro circular barrier assays, discrete random walk simulations and pair correlation functions. In particular, we analyse discrete simulation data using pair correlation functions to show that spatial structure can form in a spreading population of cells either through sufficiently strong cell–to–cell adhesion or sufficiently rapid cell proliferation. We analyse images from a circular barrier assay describing the spreading of a population of MM127 melanoma cells using the same pair correlation functions. Our results indicate that the spreading melanoma cell populations remain very close to spatially uniform, suggesting that the strength of cell–to–cell adhesion and the rate of cell proliferation are both sufficiently small so as not to induce any spatial patterning in the spreading populations. Scientific Reports 4 doi: 10.1038/srep05713
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 5
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    HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy (2017)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2017-05-06
    Description: Nature Medicine 23, 638 (2017). doi:10.1038/nm.4319 Authors: Jenna B Honeycutt, William O Thayer, Caroline E Baker, Ruy M Ribeiro, Steven M Lada, Youfang Cao, Rachel A Cleary, Michael G Hudgens, Douglas D Richman & J Victor Garcia Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppressive ART has not been established. Using humanized myeloid-only mice (MoM), we demonstrate that HIV infection of tissue macrophages is rapidly suppressed by ART, as reflected by a rapid drop in plasma viral load and a dramatic decrease in the levels of cell-associated viral RNA and DNA. No viral rebound was observed in the plasma of 67% of the ART-treated animals at 7 weeks after ART interruption, and no replication-competent virus was rescued from the tissue macrophages obtained from these animals. In contrast, in a subset of animals (∼33%), a delayed viral rebound was observed that is consistent with the establishment of persistent infection in tissue macrophages. These observations represent the first direct evidence, to our knowledge, of HIV persistence in tissue macrophages in vivo.
    Print ISSN: 1078-8956
    Electronic ISSN: 1546-170X
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 6
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    ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-12-24
    Description: ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons Nature Communications, Published online: 23 December 2016; doi:10.1038/ncomms14021 Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery and ribosomes required for efficient ribosome release at premature termination codons.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor (2018)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2018-04-05
    Description: S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor, Published online: 04 April 2018; doi:10.1038/s41598-018-23371-w S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 8
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    Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri (2018)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2018-10-23
    Description: Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri Investigation of inter- and intraspecies variation through genome sequencing of 〈i〉Aspergillus〈/i〉 section 〈i〉Nigri〈/i〉, Published online: 22 October 2018; doi:10.1038/s41588-018-0246-1 De novo assembly of 23 Aspergillus section Nigri and 6 Aspergillus niger genome sequences allows for inter- and intraspecies comparisons and prediction of secondary metabolite gene clusters.
    Print ISSN: 1061-4036
    Electronic ISSN: 1546-1718
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 9
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    Self-organizing and stochastic behaviors during the regeneration of hair stem cells (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-30
    Description: Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321266/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321266/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plikus, Maksim V -- Baker, Ruth E -- Chen, Chih-Chiang -- Fare, Clyde -- de la Cruz, Damon -- Andl, Thomas -- Maini, Philip K -- Millar, Sarah E -- Widelitz, Randall -- Chuong, Cheng-Ming -- AR47364/AR/NIAMS NIH HHS/ -- AR60306/AR/NIAMS NIH HHS/ -- R01 AR042177/AR/NIAMS NIH HHS/ -- R01 AR042177-17/AR/NIAMS NIH HHS/ -- R01 AR042177-18/AR/NIAMS NIH HHS/ -- R01 AR060306/AR/NIAMS NIH HHS/ -- R01 AR060306-02/AR/NIAMS NIH HHS/ -- R01 AR060306-03/AR/NIAMS NIH HHS/ -- R01-AR42177/AR/NIAMS NIH HHS/ -- R01-AR47709/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):586-9. doi: 10.1126/science.1201647.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Southern California (USC), Los Angeles, CA 90033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527712" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Morphogenetic Proteins/*metabolism ; Computer Simulation ; Hair Follicle/*cytology/*growth & development/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Biological ; Rabbits ; *Regeneration ; *Signal Transduction ; Stem Cells/*physiology ; Stochastic Processes ; Wnt Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    The plant cell wall-decomposing machinery underlies the functional diversity of forest fungi (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-19
    Description: Brown rot decay removes cellulose and hemicellulose from wood--residual lignin contributing up to 30% of forest soil carbon--and is derived from an ancestral white rot saprotrophy in which both lignin and cellulose are decomposed. Comparative and functional genomics of the "dry rot" fungus Serpula lacrymans, derived from forest ancestors, demonstrated that the evolution of both ectomycorrhizal biotrophy and brown rot saprotrophy were accompanied by reductions and losses in specific protein families, suggesting adaptation to an intercellular interaction with plant tissue. Transcriptome and proteome analysis also identified differences in wood decomposition in S. lacrymans relative to the brown rot Postia placenta. Furthermore, fungal nutritional mode diversification suggests that the boreal forest biome originated via genetic coevolution of above- and below-ground biota.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eastwood, Daniel C -- Floudas, Dimitrios -- Binder, Manfred -- Majcherczyk, Andrzej -- Schneider, Patrick -- Aerts, Andrea -- Asiegbu, Fred O -- Baker, Scott E -- Barry, Kerrie -- Bendiksby, Mika -- Blumentritt, Melanie -- Coutinho, Pedro M -- Cullen, Dan -- de Vries, Ronald P -- Gathman, Allen -- Goodell, Barry -- Henrissat, Bernard -- Ihrmark, Katarina -- Kauserud, Havard -- Kohler, Annegret -- LaButti, Kurt -- Lapidus, Alla -- Lavin, Jose L -- Lee, Yong-Hwan -- Lindquist, Erika -- Lilly, Walt -- Lucas, Susan -- Morin, Emmanuelle -- Murat, Claude -- Oguiza, Jose A -- Park, Jongsun -- Pisabarro, Antonio G -- Riley, Robert -- Rosling, Anna -- Salamov, Asaf -- Schmidt, Olaf -- Schmutz, Jeremy -- Skrede, Inger -- Stenlid, Jan -- Wiebenga, Ad -- Xie, Xinfeng -- Kues, Ursula -- Hibbett, David S -- Hoffmeister, Dirk -- Hogberg, Nils -- Martin, Francis -- Grigoriev, Igor V -- Watkinson, Sarah C -- New York, N.Y. -- Science. 2011 Aug 5;333(6043):762-5. doi: 10.1126/science.1205411. Epub 2011 Jul 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Science, University of Swansea, Singleton Park, Swansea SA2 8PP, UK. d.c.eastwood@swansea.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764756" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/microbiology ; Basidiomycota/classification/enzymology/*genetics/physiology ; *Biodiversity ; Biological Evolution ; Biota ; Cell Wall/*metabolism ; Coniferophyta/microbiology ; Coriolaceae/enzymology/genetics/physiology ; Gene Expression Profiling ; Genes, Fungal ; Genomics ; Lignin/metabolism ; Mycorrhizae/enzymology/*genetics/physiology ; Oxidoreductases/genetics/metabolism ; Peroxidases/genetics/metabolism ; Phylogeny ; Proteome ; Symbiosis ; Trees/*microbiology ; Wood/metabolism/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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