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  • American Association for Cancer Research (AACR)  (16)
  • 1
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5800-5800
    Abstract: Triple-negative breast cancer (TNBC) is the most deadly and aggressive phenotype, with a higher rate of metastatic recurrence. TNBC does yet have a suitable treatment option other than cytotoxic anticancer drugs. Although pitavastatin has been shown to exert anti-proliferative effects and cytotoxicity in various types of cancer cells, the precise mechanisms underlying pitavastatin’s anti-cancer effects in TNBC have not been fully elucidated. We sought to investigate the mechanism of pitavastatin-induced apoptosis and its effects on cancer stem cell (CSC)-like characteristics in TNBC. Exposure to pitavastatin induced mitochondria-mediated apoptotic cell death in BT549 and 4T1 cells. Mitochondrial dysfunction was accompanied with a robust production of reactive oxygen species (ROS) and collapse of mitochondrial membrane potential (MMP), resulting in subsequent activation of caspase-3/-7 and PARP cleavage. Pitavastatin effectively suppressed CSC-like properties in TNBC via targeting CD44+/CD24- and CD49f+/CD24- phenotypes, as well as impediment of mammosphere formation in vitro. This phenomenon was accompanied with dysregulation of STAT3 survival pathway, concomitant with significant downregulation of cyclin D1, survivin and vimentin. Pitavastatin effectively targets both the proliferating TNBC tumor cells and CSCs via the dysregulation of STAT3 and suppression of CSC-like properties, markedly reducing angiogenesis and tumor growth, coinciding with decreased Ki-67 expression. It is noteworthy that pitavastatin considerably suppressed metastasis, coinciding with significant reduction of MMP-2, MMP-9 and VEGF in the circulating blood of mice. Our findings highlight that pitavastatin may be potentially effective for the treatment of metastatic TNBC. Citation Format: Dongmi Ko, Juyeon Seo, Seongjae Kim, Soeun Park, Minsu Park, Kee Dal Nam, Yong koo Kang, Sora Seock, Eunsun Jung, Yoon-Jae Kim, Jaeyoun Park, Ji Young Kim, Jae Hong Seo. Anti-metastatic potential of pitavastatin in triple-negative breast cancer via targeting breast cancer stem-like properties and STAT3 signaling. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5800.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
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  • 2
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    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5903-5903
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5903-5903
    Abstract: Background: Biliary tract cancer (BTC) is an aggressive malignancy associated with a poor prognosis. Most BTC patients are diagnosed at an unresectable stage; further, the efficacy of cytotoxic chemotherapy for BTC remains unsatisfactory. Recently, there is growing evidence that gut microbial dysbiosis is related to multiple diseases, including biliary disease and cancer. However, the association between tumor and gut microbiome environments and BTC, especially extrahepatic cholangiocarcinoma (EH-CCA), remains unclear. In the present study, we compared the microbiome from the tissue and stool samples of EH-CCA patients and healthy living liver donors (controls). Methods: A total of 24 people (13 EH-CCA patients and 11 healthy controls) were included. We collected fecal and swab samples, which were obtained from the EH-CCA tissues of the patients and normal gallbladder tissues of the controls during operation. The bacterial 16S rRNA gene (V3 and V4 region) was amplified using PCR and sequenced on the Illumina MiSeq platform. The QIIME 2 pipelines were used to analyze the raw data. Results: The median age of the patients and controls were 70 (range, 58-79) and 29 (range, 19-35) years, respectively. The swab samples from EH-CCA patients showed significantly lower alpha diversity than the samples from the controls (pShannon & lt; 0.001). Proteobacteria was the most commonly found phylum (53%) in the EH-CCA patients; Firmicutes (79%) and Actinobacteria (13%) were the common phyla in the controls. The genera Streptococcus (25.1%), Escherichia_Shigella (16.9%), and Enterococcus (13.9%) were found in the patient samples, whereas Blautia (12%), Limosilactobacillus (12%), and Bifidobacterium (19%) were observed in the controls. The Principal Coordinate Analysis (PCoA) plot of the weighted UniFrac distances showed that the patient and control groups formed separate clusters. Among the fecal samples, Streptococcus (12.5%), bacterioides (8.2%) is most common in patients’ group, whereas Blautia (13.8%) and Faecalibacterium (11.5%) is most common in control group at the gene levels. The PCoA plot of the fecal samples showed significant differences in microbiota composition between the EH-CCA patients and healthy controls (P=0.001 by PERMANOVA). In the beta diversity analysis of all samples (swab plus fecal), the patient-swab samples formed distinct clusters, whereas the patient-fecal, control-swab, and control-fecal samples showed overlapping clusters.Conclusions: To the best of our knowledge, this study is the first that compares the microbiome of tissues and stools from EH-CCA patients and healthy controls; the EH-CCA patients and healthy controls showed different microbiota profiles. Further studies are needed to investigate the clinical implications of microbial dysbiosis in BTC and formulate novel microbiome-based treatments for BTC. Citation Format: Sora Kang, Jihee Kang, Gun-Seok Park, Seung-Hyun Ko, Jung-Hyun Park, Yunseon Jang, Ik-Chan Song, Hyewon Ryu, Seok-Hwan Kim. Comparison of the tissue and gut microbiome in extrahepatic cholangiocarcinoma patients and healthy liver donors. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5903.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
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  • 3
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    American Association for Cancer Research (AACR) ; 2015
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 24, No. 10_Supplement ( 2015-10-01), p. A02-A02
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 24, No. 10_Supplement ( 2015-10-01), p. A02-A02
    Abstract: Pacific Islanders (PIs) in the United States have among the highest prevalence of cigarette smoking and alcohol use both of which contribute significantly to increased risk for cancer. Across racial/ethnic groups, late adolescents and young adults between the ages of 18 and 30 years are particularly vulnerable to tobacco and alcohol use. The community-based participatory research (CBPR) program “Weaving an Islander Network for Cancer Awareness, Research, and Training (WINCART)” consisting of community researchers from five NHPI-led community-based organizations (CBOs) and academic researchers are collaborating on the development, implementation, and evaluation of a culturally attuned smoking cessation intervention for young adult PIs entitled “Motivating Pasifika against Cigarettes and Tobacco (MPACT).” Findings from MPACT baseline data provide a description of tobacco and alcohol use patterns in a community sample of young adult PI cigarette smokers in Southern California. The sample of 200 comprised 103(51.5%) males, primarily U.S. born participants 167(84.4%), and individuals self-identifying mostly as either Samoan 106(53%) or Tongan 82(41%). Education level for the majority was completion of high school or GED 89(45.4%) or some college or trade school 77(39.3%). Just over half 113(56.5%) were employed and only 113(56.5%) reported having medical insurance coverage. Regarding general health status, 84(42.6%) of participants rated their health good-excellent, while 113(57.3%) reported their health as fair-poor. Most of the sample reported light to moderate cigarette smoking, 83(43.2%) reported concurrent 30-day E-cigarette or vaping use, and 154(78.2%) smoked menthol cigarettes. Most 127(65.8%) believed that E-cigarettes or vaping were less harmful than cigarettes. The majority of the sample, 153(81%) reported past month alcohol use, 132(69.5%) reported binge drinking on a least one day during that time, and 71(37.4%) reported past month binge drinking on 3 days or more. Utilizing the Center for Epidemiologic Studies Depression (CES-D) Scale, a screening test for depression and depressive disorder, 87(47%) of the sample, reported symptoms consistent with a clinical diagnosis. These findings indicate that our study sample comprised young adult PIs smokers with a high unemployment rate, low-moderate education level, high fair to poor self-reported health status, light to moderate cigarette use with high concurrent rates of E-cigarette or vaping use, high rates of alcohol use, in particular, binge drinking, and high rates of depressive symptoms. These findings indicate the need for health education, preventive health services, and further research regarding tobacco and alcohol use health disparities that increase cancer risk in this Pacific Islander population. Citation Format: Paula Palmer, Sora Park Tanjasiri, Vanessa Tui'one May, Tupou Toilolo, Victor Kaiwi Pang, Dorothy Etimani Vaivao, Melanie Sabado, Nasya Tan, James Pike, Melevesi Fifita Talavou, Genesis Lutu, Bin Xie. Tobacco and alcohol comorbidities among young adult Pacific Islanders. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr A02.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2015
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  • 4
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    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 26, No. 2_Supplement ( 2017-02-01), p. A37-A37
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 26, No. 2_Supplement ( 2017-02-01), p. A37-A37
    Abstract: Background: Pap tests comprise an essential cervical cancer prevention and detection method for women in the U.S. Unfortunately, the Pap test remains significantly underutilized among many ethnic/racial groups, particularly Pacific Islanders (PIs) who have low rates of Pap testing and high rates of cervical cancer incidence and mortality. Methods: A randomized community trial tested the efficacy of a social support-informed culturally developed intervention on increasing Pap testing among Chamorro, Samoan and Tongan women in Southern California. Using community-based participatory research (CBPR), Pacific Islander women and their husbands/partners were recruited from social organizations (churches and clans) that had been randomly assigned to receive the intervention or control education. Three waves (pretest, posttest and 6-month follow-up) of data collection included demographics, cervical cancer beliefs, social support between women and their husbands/partners, and Pap test attitudes and behaviors. Results: CBPR recruitment resulted in a total of 81 social organizations recruited that included n=575 Pacific Islander women and n=461 husbands/partners. Significant differences between groups at baseline included acculturation and health insurance coverage. Six month follow-up found that all women from baseline significantly increased knowledge and decreased fatalistic attitudes towards Pap testing. Women who were not adherent to Pap test guidelines in the intervention group had significantly higher rates of Pap testing compared to controls at six month follow-up. No differences were found in either women's perceived social support nor men's provision of social support for Pap testing. Conclusion: CBPR-informed behavioral interventions can increase cervical cancer screening in Pacific Islander women. Although social support did not mediate the relationship between women's knowledge and behavior, it did inform the development of a culturally tailored intervention for Chamorro, Samoan and Tongan women. Future studies can build upon these results by addressing other early detection (e.g., mammograms, colorectal exams, etc) and prevention (e.g., HPV vaccination) in these and other disparity populations. Citation Format: Sora Park Tanjasiri, Jie W. Weiss, Michele Mouttapa, Lola Sablan Santos. Outcomes of a Randomized Community Trial to Increase Pap Testing among Pacific Islanders in Southern California. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr A37.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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  • 5
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    American Association for Cancer Research (AACR) ; 2018
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 27, No. 7_Supplement ( 2018-07-01), p. IA31-IA31
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 27, No. 7_Supplement ( 2018-07-01), p. IA31-IA31
    Abstract: While cancer mortality is on the decline in the U.S., Pacific Islanders continue to experience high rates of cancer incidence, prevalence, and mortality due to the lack of appropriate, understandable, and accessible prevention, early detection, and treatment/survivorship information and services. California is home to the second-largest populations of Pacific Islanders, including Chamorros, Marshallese, Native Hawaiians, Samoans, and Tongans. In 2005 community and university researchers formed a multicommunity collaboration for cancer prevention and control called WINCART: Weaving an Islander Network for Cancer Awareness, Research and Training. Using a community-based participatory research (CBPR) approach, this collaboration developed decision-making processes, protocols, and MOUs that prioritized community benefits in the design and implementation of studies spanning the cancer control continuum including tobacco cessation, nutrition and physical activity promotion, colorectal screening, breast screening, Pap testing, cancer survivorship, and biospecimen collection. Specifically, this presentation will cover the elements that contributed to WINCART's successful CBPR collaborations, provide examples from selected studies, and share lessons learned for researchers interested in initiating or sustaining community-university partnerships in the future. Citation Format: Sora Park Tanjasiri, Paula Healani Palmer. Not showing up empty-handed: A multicommunity collaboration for cancer prevention and control [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA31.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2018
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  • 6
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 2941-2941
    Abstract: ROR1, a member of the ROR (Receptor Tyrosine Kinase-Like Orphan Receptor)-family, is overexpressed in the process of embryo and fetal development, and controls cell polarity, cell migration and neurite growth. The expression is gradually reduced as development progresses, and it is hardly expressed in adults, but the overexpression of ROR1 is observed in various blood and solid cancer cells, so it is classified as an oncofetal gene. ABL102, a First-in-Class bispecific antibody targeting ROR1 and 4-1BB, elicits superior T cell activation by tumor specific T cell engagement through ROR1 dependent 4-1BB clustering. Our data showed that tumor target dependents binding of ROR1 and costimulatory 4-1BB by ABL102 induced 4-1BB activation in cell-based 4-1BB bioassay. ABL102 lead to IFN-γ secretion and tumor cell killing with a ROR1 dependent manner in co-culture assay with tumor cells and human PBMC. In h4-1BB knock-in mouse model bearing hROR1-expressing tumors, ABL102 potently inhibited tumor progression with a high rate of complete remission (CR). Mice with CR were further protected from the rechallenge of previously exposed tumors after 3 months of cessation of ABL102 treatment, implicating that immunological memory might be generated. In 4-week pilot toxicity study using cynomolgus monkeys, no ABL102-related toxicity was observed up to 100mg/kg, including mortality, body weight, hematology, liver toxicity, clinical chemistry and pathology, indicating a favorable safety profile. In conclusion, ABL102 exhibited potent in vitro and vivo anti-tumor activity and it was well tolerated and safe in the NHP toxicity study. These results strongly suggest that ABL102 is promising therapeutics for ROR1 positive cancer patients. Citation Format: Yangsoon Lee, Kyeong-Su Park, Wonjun Son, Sora Kim, Hyunseong Youn, Jiseon Yoo, Hanbyul Lee, Jonghwa Won. ROR1 targeted 4-1BB costimulatory bispecific antibody, ABL102, exhibits potent in vitro and vivo antitumor activity and superior safety profile [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2941.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
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  • 7
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 12_Supplement ( 2020-12-01), p. PO-021-PO-021
    Abstract: Introduction: Orange County (OC) is home to the third-largest population of Asian Americans in the U.S., including the largest population of Vietnamese outside of Vietnam. While breast, lung and colorectal cancers are the top overall causes of cancer incidence and mortality in OC, unique cancers are prevalent among Asian and Pacific Islanders including liver and stomach cancers. The University of California, Irvine Chao Family Comprehensive Cancer Center (UCI CFCCC) adapted a hub-and- spoke model of care (Elrod & Fortenberry, 2017) to increase efficiency among underserved Asian Americans who continue to experience disparities in screening, early detection, and access to cancer treatment. Methods: Our hub-and-spoke model arranges service delivery assets into a network between community organizations through culturally/linguistically competent and trained community health navigators, OC medicaid primary and specialty care providers for low/moderate complexity patients, and UCI CFCCC for high-complexity cancer treatment. UCI CFCCC serves as the anchor establishment (hub) which offers a full array of services. This is complemented by community providers and care coordinators at local Federally Qualified Health Centers (spokes) which offer culturally-tailored primary prevention services. The community patient navigators (rim) located at community-based organizations, routes patients needing more tailored services to the spokes or hub for screening or treatment. Results: Patient Navigators at OC Herald Center, OC Asian Pacific Islander Community Alliance, and Vietnamese American Cancer Foundation have educated 2,246 Korean, Vietnamese, and Chinese individuals on cancer prevention and screening guidelines. Of those, 320 medicaid members have been routed to KCS Health Centers (Korean-serving FQHC lookalike), Southland Integrated Services, Inc (Vietnamese and Chinese-serving FQHC), or Medicaid community providers for cancer screening and/or follow-up. 64 community providers have been trained on NCCN guideline adherent care for Korean, Vietnamese, and Chinese. UCI CFCCC has developed an algorithm/pathway for Medicaid-serving community physicians to easily refer qualified Vietnamese, Chinese, or Korean patients to the hub for complex care or clinical trials. Conclusions: The current COVID-19 pandemic has exacerbated disparities in screening and early detection, and compounds the uncertainty about the importance of optimizing cancer care quality (i.e. access proportion and timeliness, adherence to guidelines, patient satisfaction). Disparities being highlighted in COVID-19 has shown us the power and need of community engagement models to rapidly catalyze and create unique community-based efforts that strengthen capacities and infrastructures, and promote best practices in cancer prevention and early detection designed to decrease cancer incidence and/or mortality in the communities we serve. Citation Format: Cevadne Lee, Ellen Ahn, Mary Anne Foo, Sherry Huang, Becky Nguyen, Tricia Nguyen, Jacqueline Tran, Robert Bristow, Sora Park Tanjasiri. A hub and spoke model to improve cancer care quality: Advancing Cancer Care Together (ACCT) for Asian American Medicaid beneficiaries in Orange County, California [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-021.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
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  • 8
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    American Association for Cancer Research (AACR) ; 2016
    In:  Cancer Research Vol. 76, No. 14_Supplement ( 2016-07-15), p. 460-460
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 76, No. 14_Supplement ( 2016-07-15), p. 460-460
    Abstract: Background: An active cyclin D1 isoform, cyclin D1b, arises as a result of a failure to splice the fourth intron of the CCND1 pre-mRNA transcript. The expression of cyclin D1b has been associated with tumorigenesis and tumor progression in many types of human cancer. However, no studies with cyclin D1b have yet been reported in the thyroid cancer. Methods: We investigated the CCND1 rs9344 (cDNA 870) polymorphism by TaqMan SNP genotyping assay and expression profiles of mRNA and protein of full-length cyclin D1 (cyclin D1a) and cyclin D1b by quantative real-time PCR and immunohistochemistry in 286 thyroid tumors including 16 nodular hyperplasias, 33 follicular adenomas (FA), 179 papillary thyroid carcinomas (PTC), 32 follicular thyroid carcinomas (FTC), 5 poorly differentiated carcinomas (PDC), 4 anaplastic thyroid carcinomas (ATC), and 17 medullary thyroid carcinomas (MTC). The relationships between cyclin D1 expression levels and clinicopathological features were analyzed. Results: The cyclinD1b mRNA expression level in all thyroid tumors was significantly higher in the AA and GA genotype groups compared with the GG genotype group (p & lt;0.001 and p = 0.006, respectively). The mRNA expression levels of cyclin D1b was significantly higher in PTCs when compared to benign or other malignant tumors (p & lt;0.001) while no significant difference in cyclin D1a mRNA expression was observed according to the genotypes or tumor types. PTCs showed similar expression levels of cyclin D1b mRNA regardless of histologic subtypes, even when compared with follicular variant. In immunohistochemistry analysis, cyclin D1b overexpression was observed in PTC, PDC, ATC, and MTC, but not in FA and FTC. Cytoplasmic overexpression of cyclin D1b was significantly associated with advanced tumor stage in all PTCs (p = 0.025). Nuclear overexpression of cyclin D1b was associated with an increased incidence of lymph node metastases (p = 0.014) in classic PTCs. Conclusion: The A allele of the rs9344 polymorphism predisposes for cyclin D1b production in thyroid cancer. Cyclin D1b overexpression has a diagnostic biomarker utility to differentiate PTC from benign follicular nodules and may be functionally involved in the progression of the disease. Citation Format: Chan Kwon Jung, Sora Jeon, Yourha Kim, Ahwon Lee, Gyeong Sin Park. Diagnostic and prognostic value of expression of CCND1 splice variant cyclin D1b in papillary thyroid carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 460.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    RVK:
    RVK:
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2016
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  • 9
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    American Association for Cancer Research (AACR) ; 2014
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 23, No. 11_Supplement ( 2014-11-01), p. B67-B67
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 23, No. 11_Supplement ( 2014-11-01), p. B67-B67
    Abstract: Background: Pacific Islanders (PIs) experience high cancer health disparities, including later stage of cervical cancer diagnosis due in large part to more than 10% lower Pap screening rates compared to non-Hispanic Whites. The aim of this community-based participatory research (CBPR) randomized control intervention is to increase rates of Pap testing among PI women residing in Southern California. Baseline data examined whether a Multi-Attribute Utility (MAU) model (a descriptive behavioral decision-making model) and women's perceived receipt of social support from their husband/partner significantly predicted Pap testing within the past three years. We also examined whether social support mediated the relationship between utility and Pap testing. Procedures: PI couples were recruited from Samoan, Tongan, and Chamorro churches and cultural social networks, and were randomly assigned to one of two educational interventions regarding cervical cancer screening. Participating women had to be between 21 and 65 years old and married or in a long-term relationship. A baseline questionnaire assessed women's MAU decision-making parameters (subjective value, subjective likelihood, and momentary salience) for eight anticipated consequences of getting a Pap test. Items also assessed female participants' perceived social support (appraisal, emotional, instrumental, and informational) from their husband/partner, and Pap testing behaviors. Results: Only half of the participants (49.9%) had received a Pap test within the past three years. A logistic regression model indicated that the total MAU score (which is the sum of the products of perceived subjective value, perceived subjective likelihood, and momentary salience across the eight parameters) was associated with higher rates of Pap testing (AOR= 1.10, p & lt; 0.01). Four additional logistic regression models were run, one for each of the four different social support subscales. Appraisal support (AOR= 1.21, p= 0.000), emotional support (AOR= 1.25, p= 0.000), informational support (AOR= 1.13, p & lt; 0.000), and instrumental support (AOR= 1.19, p= 0.000) were all associated with higher rates of Pap testing. Next, four mediational models were run, one for each of the four social support subscales, with instrumental support significantly mediating the relationship between MAU total scores and Pap testing. Specifically, the mediational model indicated MAU total scores had both a direct relationship with increased Pap testing, as well as an indirect relationship with increased Pap testing through its relationship with increased instrumental support. Conclusions: Results indicate that PI women's Pap testing follows a personal decision, with husband/partner's instrumental support enhancing the decision to receive a Pap test. Provision of such social support is the basis for the present intervention that educates men about the importance of expressing their concern for, and intention to assist with, regular Pap testing among PI women. Citation Format: Sora Park Tanjasiri, Jie Wu Weiss, Michele Mouttapa, Lola Sablan Santos, Jasmine Lacsamana DeGuzman, Vanessa Tuione May, Lourdes Quitugua, Dorothy Vaivao. Role of social support in Pap test decision making among Pacific Islander women. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B67. doi:10.1158/1538-7755.DISP13-B67
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2014
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  • 10
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    American Association for Cancer Research (AACR) ; 2020
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. B007-B007
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. B007-B007
    Abstract: Cancer continues to be the leading cause of death in Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs), with over one-third of the AANHPI population residing in California and Hawai’i. Due to linguistic, cultural, and sociodemographic differences, cancer prevention, control, and treatment remains a challenge. These compounded factors hinder AANHPIs from seeking care or following through with provider’s recommendations as they experience high level of dissatisfaction in care, risk of misdiagnosis or ineffective treatment plans, resulting in low levels of engagement with the healthcare system. This has called for a need to create partnerships and improve coordination between community, primary care, and specialty care. The Bristol-Myers Squibb Foundation’s Specialty Care for Vulnerable Populations initiative addresses inequities in access to and utilization of specialty care services by medically underserved and vulnerable populations in the US. The goal of this national initiative is to catalyze sustainable improvement and expansion of specialty care and health service delivery by safety net providers for people at high risk of cancer and cardiovascular disease. In response to the cancer disparities and inequities faced by AANHPI populations, the Bristol-Myers Squibb Foundation’s Specialty Care for Vulnerable Populations awarded 4 organizations $750,000 each to support 3 year health service delivery demonstration projects to improve access to quality cancer care, patient engagement, and supportive services to AANHPIs. Objectives for this session will be: • Describe the cancer disparities in Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs) • Explain current research and new partnerships to improve cancer outcomes and access for AANHPIs • Disseminate different models of care bolstering community, primary care, and specialty care in AANHPI cancer patients This session will delve into the cancer disparities apparent in AANHPIs and highlight the 4 AANHPI-dedicated projects to create better coordination between community, primary care, and specialty care: 1. University of California Davis Cancer Center/Health & Life Organization 2. University of California San Francisco 3. University of California Irvine Chao Family Comprehensive Cancer Center 4. University of Hawai’i John A. Burns School of Family Medicine These projects include forming new partnerships between a NCI comprehensive cancer center + FQHC-lookalike; testing an in-person and virtual patient navigation portal; utilizing a hub-and-spoke model between primary care, FQHCs, and specialty care; and bolstering telehealth capabilities to train workers in USAPI territories and Hawai’i on cancer topics and services. Citation Format: Priscilla Ko, Patricia Doykos, Moon Chen, Scarlett Lin Gomez, Neal Palafox, Sora Park Tanjasiri. Developing community-primary care-specialty care partnerships to address cancer disparities in Asian Americans, Native Hawaiians, and Pacific Islanders [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B007.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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