In:
European Journal of Microbiology and Immunology, Akademiai Kiado Zrt., Vol. 10, No. 2 ( 2020-06), p. 98-106
Abstract:
Listeria monocytogenes ( Lm ) is a food-borne pathogen with a high chance of infecting neonates, pregnant women, elderly and immunocompromised individuals. Lm infection in neonates can cause neonatal meningitis and sepsis with a high risk of severe neurological and developmental sequelae and high mortality rates. However, whether an acute neonatal Lm infection causes long-term effects on the immune system persisting until adulthood has not been fully elucidated. Here, we established a neonatal Lm infection model and monitored the composition of major immune cell subsets at defined time points post infection (p.i.) in secondary lymphoid organs and the intestine. Twelve weeks p.i., the CD8 + T cell population was decreased in colon and mesenteric lymph nodes (mLNs) with an opposing increase in the spleen. In the colon, we observed an accumulation of CD4 + and CD8 + effector/memory T cells with an increase of T-bet + T helper 1 (Th1) cells. In addition, 12 weeks p.i. an altered composition of innate lymphoid cell (ILC) and dendritic cell (DC) subsets was still observed in colon and mLNs, respectively. Together, these findings highlight organ-specific long-term consequences of an acute neonatal Lm infection on both the adaptive and innate immune system.
Type of Medium:
Online Resource
ISSN:
2062-8633
DOI:
10.1556/1886.2020.00007
Language:
Unknown
Publisher:
Akademiai Kiado Zrt.
Publication Date:
2020
detail.hit.zdb_id:
2652327-9
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