In:
Journal of Behavioral Addictions, Akademiai Kiado Zrt., Vol. 12, No. 2 ( 2023-06-29), p. 458-470
Abstract:
Impaired value-based decision-making is a feature of substance and behavioral addictions. Loss aversion is a core of value-based decision-making and its alteration plays an important role in addiction. However, few studies explored it in internet gaming disorder patients (IGD). Methods In this study, IGD patients (PIGD) and healthy controls (Con-PIGD) performed the Iowa gambling task (IGT), under functional magnetic resonance imaging (fMRI). We investigated group differences in loss aversion, brain functional networks of node-centric functional connectivity (nFC) and the overlapping community features of edge-centric functional connectivity (eFC) in IGT. Results PIGD performed worse with lower average net score in IGT. The computational model results showed that PIGD significantly reduced loss aversion. There was no group difference in nFC. However, there were significant group differences in the overlapping community features of eFC 1 . Furthermore, in Con-PIGD, loss aversion was positively correlated with the edge community profile similarity of the edge 2 between left IFG and right hippocampus at right caudate. This relationship was suppressed by response consistency 3 in PIGD. In addition, reduced loss aversion was negatively correlated with the promoted bottom-to-up neuromodulation from the right hippocampus to the left IFG in PIGD. Discussion and conclusions The reduced loss aversion in value-based decision making and their related edge-centric functional connectivity support that the IGD showed the same value-based decision-making deficit as the substance use and other behavioral addictive disorders. These findings may have important significance for understanding the definition and mechanism of IGD in the future.
Type of Medium:
Online Resource
ISSN:
2062-5871
,
2063-5303
DOI:
10.1556/2006.2023.00014
Language:
Unknown
Publisher:
Akademiai Kiado Zrt.
Publication Date:
2023
detail.hit.zdb_id:
2817933-X
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