In:
Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3083-3083
Abstract:
An approach to applying the histotripsy-like mechanical effects of ultrasound for cancer treatments is studied. We investigated the combinational effects of pulsed ultrasound at intensities used for HIFU (high intensity focused ultrasound) therapy and a type of locally injected superheated perfluorocarbon droplet (PCND). The droplets produce microbubbles when exposed to ultrasound. In our approach, chemical agents are also added to obtain combined mechanical and chemical antitumor effects. It was found that, in the presence of locally injected PCND, spatially controlled mechanical effects similar to histotripsy can be achieved with pulsed ultrasound (pHIFU) at several kW/cm2ex vivo. Further, it was suggested that even if the target volume is too vast to distribute PCND with a single injection, one injection is enough because PCND particles migrate inside tissues due to pHIFU. Further, the antitumor effects of pHIFU in combination with the local injection of PCND and an antitumor agent (Adriamycin) were investigated in vivo using murine tumors (Colon 26). Experiments were performed under acoustic conditions and with drug doses not severe enough to induce significant antitumor effects. It was found that PCND and Adriamycin were effective at suppressing tumor growth and tumor regrowth after suppression, respectively. The obtained results are very promising for developing novel cancer treatments.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2016
detail.hit.zdb_id:
1461063-2
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