In:
International Journal of Bioprinting, AccScience Publishing, Vol. 8, No. 3 ( 2022-06-08), p. 578-
Abstract:
In nature, many biological tissues are composed of oriented structures, which endow tissues with special properties and functions. Although traditional hydrogels can achieve a high level of biomimetic composition, the orderly arrangement of internal structures remains a challenge. Therefore, it is of great significance to synthesize hydrogels with oriented structures easily and quickly. In this study, we first proposed and demonstrated a fabrication process for producing a well-ordered and dual-responsive cellulose nanofibers + hyaluronic acid methacrylate (CN+HAMA) hydrogels through an extrusion-based three-dimensional (3D) printing process. CN in the CN+HAMA hydrogels are directionally aligned after extrusion due to shear stress. In addition, the synthesized hydrogels exhibited responsive behaviors to both temperature and ultraviolet light. Since the temperature-responsiveness is reversible, the hydrogels can transit between the gelation and solution states while retaining their original qualities. Furthermore, the developed well-oriented CN+HAMA hydrogels induced directional cell growth, paving the way for potential applications in ordered biological soft-tissue repair
Type of Medium:
Online Resource
ISSN:
2424-7723
,
2424-8002
DOI:
10.18063/ijb.v8i3.578
Language:
Unknown
Publisher:
AccScience Publishing
Publication Date:
2022
detail.hit.zdb_id:
2834694-4
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