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  • AIP Publishing  (4)
  • 1
    Online Resource
    Online Resource
    A compact gas chromatography platform for detection of multicomponent volatile organic compounds biomarkers
    AIP Publishing ; 2022
    In:  Review of Scientific Instruments Vol. 93, No. 6 ( 2022-06-01)
    Details
    In: Review of Scientific Instruments, AIP Publishing, Vol. 93, No. 6 ( 2022-06-01)
    Abstract: Some human exhaled volatile organic compounds (VOCs) can be employed to diagnose related human endogenous diseases as characteristic biomarkers, which is expected to be applied to rapid screening and grading because of their non-invasive and cost-effective advantages. In this study, we developed a compact gas chromatography (GC) platform mainly composed of an integrated silicon-based micro-column chip using micro-electromechanical system techniques and a miniaturized metal oxide semiconductor gas detector. In addition, the sampling/switching valve with related components and embedded microcontrollers was used for airflow control. The fabricated system selectively detected the five VOCs (pentane, acetone, toluene, octane, and decane) considered the typical endogenous disease biomarkers. In the experiments, the functional parameters of the system were investigated, and the optimum temperature conditions of the system for separation were determined. The results show that the system can successfully test the studied five VOCs as low as 1 ppm. In addition, the influence of interfering gas (carbon dioxide and ammonia) on the system for the VOC mixture is also investigated. Moreover, to prove the possibility of breath analysis of the fabricated system, the detection performance of isoprene and acetone at the ppb level is studied. Then, the concentration changes of the isoprene at the ppb concentration for human breath are successfully detected in the system. Therefore, we believe that the prepared compact GC system has potential applications in the human endogenous disease diagnosis for the VOC biomarkers.
    Type of Medium: Online Resource
    ISSN: 0034-6748 , 1089-7623
    URL: Article
    DOI: 10.1063/5.0086618
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 209865-9
    detail.hit.zdb_id: 1472905-2
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Non-perturbing THz generation at the Tsinghua University Accelerator Laboratory 31 MeV electron beamline
    AIP Publishing ; 2018
    In:  Review of Scientific Instruments Vol. 89, No. 9 ( 2018-09-01)
    Details
    In: Review of Scientific Instruments, AIP Publishing, Vol. 89, No. 9 ( 2018-09-01)
    Abstract: In recent experiments at Tsinghua University Accelerator Laboratory, the 31 MeV electron beam, which has been compressed to subpicosecond pulse durations, has been used to generate high peak power, narrow band Terahertz (THz) radiation by transit through different slow wave structures, specifically quartz capillaries metallized on the outside. Despite the high peak powers that have been produced, the THz pulse energy is negligible compared to the energy of the electron beam. Therefore, the THz generation process can be complementary to other beamline applications like plasma wakefield acceleration studies and Compton x-ray free electron lasers. This approach can be used at x-ray free electron laser beamlines, where THz radiation can be generated without disturbing the x-ray generation process. In the experiment reported here, a high peak current electron beam generated strong narrow band (∼1% bandwidth) THz signals in the form of a mixture of TM01 and TM02 modes. Each slow wave structure is completed with a mode converter at the end of the structure that allows for efficient ( & gt;90%) power extraction into free space. In the experiment, both modes in these two dielectric-loaded waveguides TM01 (0.3 THz/0.5 THz) and TM02 (0.9 THz/1.3 THz) were explicitly measured with an interferometer. The THz pulse energy was measured with a calibrated Golay cell at a few μJ.
    Type of Medium: Online Resource
    ISSN: 0034-6748 , 1089-7623
    URL: Article
    DOI: 10.1063/1.5042006
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2018
    detail.hit.zdb_id: 209865-9
    detail.hit.zdb_id: 1472905-2
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Measurement of pre-bunched beam’s longitudinal form factor based on radiation from a tunable-gap undulator
    AIP Publishing ; 2018
    In:  Review of Scientific Instruments Vol. 89, No. 1 ( 2018-01-01)
    Details
    In: Review of Scientific Instruments, AIP Publishing, Vol. 89, No. 1 ( 2018-01-01)
    Abstract: The form factor, representing the statistical characteristics of a bunch’s longitudinal distribution, is one of the most essential properties of a pre-bunched electron beam and is used for many types of frontier accelerator applications. We demonstrated the measurement of a pre-bunched beam’s longitudinal form factor component based on coherent radiation from a widely tunable-gap undulator. The radiation energy from bunches with different longitudinal properties was measured as a function of undulator gap. The root-mean-square length of a 60 pC ultrashort quasi-Gaussian bunch generated by linac and chicane compression ranged from 75 fs to 240 fs, as obtained by fitting the radiation energy curve. Furthermore, the form factor component of the bunch train based on nonlinear longitudinal space charge oscillation was measured, and a higher-order harmonic component was observed with the proposed method than with the widely used coherent transition radiation method. The proposed method may satisfy the requirements of sub-fs bunch length measurement with proper undulator design.
    Type of Medium: Online Resource
    ISSN: 0034-6748 , 1089-7623
    URL: Article
    DOI: 10.1063/1.5010031
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2018
    detail.hit.zdb_id: 209865-9
    detail.hit.zdb_id: 1472905-2
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Phase control with two-beam interferometry method in a terahertz dielectric wakefield accelerator
    AIP Publishing ; 2017
    In:  Applied Physics Letters Vol. 111, No. 17 ( 2017-10-23)
    Details
    In: Applied Physics Letters, AIP Publishing, Vol. 111, No. 17 ( 2017-10-23)
    Abstract: High-gradient, beam-driven wakefield acceleration in THz structures is a promising technology for future free electron lasers and colliders. In this scheme, the main beam is accelerated by the wakefield of the high current drive beam. The time separation between the main and drive beams has to be chosen carefully to ensure that the main beam is in an accelerating phase of the drive's wakefield. THz accelerating structures provide high gradient acceleration due to their small apertures, but their phase control is difficult due to the picosecond-scale period. Here, we report on a wakefield acceleration experiment in a 460 GHz dielectric wakefield accelerator (DWA). The optimum phase of the main beam during the experiment is determined with a two-beam wakefield interferometry (TBI) measurement. This is performed without the measurement of the main and drive beam bunch lengths or their separation. In TBI, the interference of the wakefields produced by the drive and main beams is measured with an integrating THz detector. The TBI signal, as a function of separation between the drive and main beams, exhibits a minimum due to destructive interference of these wakefields, which corresponds to maximum acceleration of the main beam as is confirmed by the energy spectrometer measurement. The maximum energy gain of 0.8 MeV and maximum energy loss of 1.2 MeV for the main beam have been measured, which agrees well with theoretical predictions.
    Type of Medium: Online Resource
    ISSN: 0003-6951 , 1077-3118
    URL: Article
    DOI: 10.1063/1.4999959
    RVK:
    UA 1000
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2017
    detail.hit.zdb_id: 211245-0
    detail.hit.zdb_id: 1469436-0
    Location Call Number Limitation Availability
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