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  • 1
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    Magnetic proxy climate results from the Duanjiapo loess section, southernmost extremity of the Chinese loess plateau (2008)
    AGU
    Details
    Publication Date: 2017-04-04
    Description: We report mineral magnetic results from a 7.5 m loess sequence (150 samples) from the southernmost extremity of the Chinese loess plateau (which includes the last two glacial cycles). In this area the loess sediments experienced particularly intense weathering processes. The magnetic assemblage is dominated by a mixture of pseudo-single domain (PSD) and multidomain (MD) magnetite with associated superparamagnetic (SP) grains of either magnetite or maghemite in the paleosols and weathered loess horizons. All the rock magnetic parameters fluctuate in parallel with marine sediment δ18O data over the last 150Kyr, thus reflecting changing global paleoclimatic conditions. This relationship is also supported by the evidence of Milankovitch cycles in the magnetic susceptibility record. Paleorainfall estimates, when compared with other studies from the Chinese loess plateau, underline the (more) humid character of this region during the last ~130 kyr.
    Description: Published
    Description: 645-659
    Description: JCR Journal
    Description: reserved
    Keywords: magnetic mineralogy ; climatic cycles ; Loess ; China ; 01. Atmosphere::01.01. Atmosphere::01.01.02. Climate ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism ; 04. Solid Earth::04.05. Geomagnetism::04.05.07. Rock magnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
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    Lack of correlation between paleoprecipitation and magnetic susceptibility of Chinese loess/paleosol sequences (2008)
    AGU
    Details
    Publication Date: 2017-04-04
    Description: We have conducted a detailed mineral magnetic study of loess unit 8 (L8) and paleosol unit 8 (S8) from three localities (Jingbian, Yichuan, and Duanjiapo) along a N-S transect in the Chinese loess plateau. As expected, the lowfield magnetic susceptibility (χ) has higher values in S8 and lower values in L8. Similarly, superparamagnetic particle concentrations increase in S8 with increasingly humid climates along the N-S transect, which suggests that pedogenic magnetic enhancement is related to climate. However, in S8 at Duanjiapo, χ is so low that there is no correlation between χ and the degree of pedogenesis in this loess-paleosol cycle. It therefore appears that χ is not consistently the most suitable indicator of paleoclimate in Chinese loess-paleosol sequences. Our results indicate that there are complexities in the mineral magnetic response to pedogenesis, which could invalidate interpretation of the χ record of Chinese loess-paleosol sequences in terms of paleoprecipitation.
    Description: Published
    Description: 4259-4262
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: N/A or not JCR
    Description: reserved
    Keywords: rock magnetism ; magnetic susceptibility ; Chinese loess/paleosol sequences ; 04. Solid Earth::04.05. Geomagnetism::04.05.07. Rock magnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism (2017)
    American Society of Hematology (ASH)
    In: Blood
    Details
    Publication Date: 2017-03-17
    Description: The hematopoietic stem cell–enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads to expansion of hematopoietic stem cells accompanied by perturbed hematopoiesis with mostly myeloproliferative phenotypes. However, whether and how miR-125 family miRNAs cooperate with known AML oncogenes in vivo, and how the resultant leukemia is dependent on miR-125 overexpression, are not well understood. We modeled the frequent co-occurrence of miR-125b overexpression and MLL translocations by examining functional cooperation between miR-125b and MLL-AF9 . By generating a knock-in mouse model in which miR-125b overexpression is controlled by doxycycline induction, we demonstrated that miR-125b significantly enhances MLL-AF9 –driven AML in vivo, and the resultant leukemia is partially dependent on continued overexpression of miR-125b . Surprisingly, miR-125b promotes AML cell expansion and suppresses apoptosis involving a non–cell-intrinsic mechanism. MiR-125b expression enhances VEGFA expression and production from leukemia cells, in part by suppressing TET2 . Recombinant VEGFA recapitulates the leukemia-promoting effects of miR-125b , whereas knockdown of VEGFA or inhibition of VEGF receptor 2 abolishes the effects of miR-125b . In addition, significant correlation between miR-125b and VEGFA expression is observed in human AMLs. Our data reveal cooperative and dependent relationships between miR-125b and the MLL oncogene in AML leukemogenesis, and demonstrate a miR-125b - TET2 - VEGFA pathway in mediating non–cell-intrinsic leukemia-promoting effects by an oncogenic miRNA.
    Keywords: Myeloid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology (ASH)
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  • 4
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    IL-4 rescues surface IgM expression in chronic lymphocytic leukemia (2016)
    American Society of Hematology (ASH)
    In: Blood
    Details
    Publication Date: 2016-07-29
    Description: Chronic lymphocytic leukemia (CLL) cells express poor levels of surface immunoglobulin (sIg), and many are minimally activated or anergic in response to B-cell receptor (BCR) crosslinking in vitro. Paradoxically, CLL cells in patients are highly activated through BCR signaling and expand in proliferation centers, suggesting that the function of sIg signaling is rescued. Here, we find that, compared with normal naïve B cells, CLL cells express a low level of total CD79b protein but normal levels of CD79a and IgM protein. Association of both CD79a and CD79b to IgM is markedly reduced. We further find that interleukin-4 (IL-4) markedly rescues CD79b and sIgM protein in CLL samples. These changes significantly enhance signaling in response to BCR crosslinking. Furthermore, we find that these changes are more pronounced in immunoglobulin heavy chain variable ( IGHV )-unmutated CLL cells than IGHV -mutated CLL cells. The results described herein reveal that reduced sIgM is due to low expression of total CD79b protein in CLL cells. IL-4 substantially restores CD79b protein expression, sIgM expression, and BCR signaling.
    Keywords: Lymphoid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology (ASH)
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