In:
Research Journal of Pharmacy and Technology, A and V Publications
Abstract:
A network of proinflammatory cytokines plays an important role in the pathogenesis of osteoarthritis and rheumatoid arthritis. Among these pro-inflammatory cytokines, IL-1 superfamily cytokines like IL-1α, IL-1β, IL-18, IL-33, IL-36 (α, β, γ) play a pivotal role in the pathogenesis in both osteoarthritis & rheumatoid arthritis. IL-1β produced by activated macrophages, activated chondrocytes, synoviocytes, osteoarthritic cartilage & subchondral bone. Various literature reveals that IL-1β also plays deleterious effects in cartilage destruction in osteoarthritis & rheumatoid arthritis by increasing the release of various proteolytic enzymes like A Disintegrin-like and Metalloproteinases with Thrombospondin Motifs (ADAMTS) and matrix metalloproteinases (MMPs) like MMP-1, MMP-3 and MMP-13. Apart from this, IL-1β also increases the expression of cathepsin B in chondrocytes that act as an important mediator of cartilage degradation. Novel anti-osteoarthritic drug diacerein shows pro-anabolic, anticatabolic and anti-inflammatory effects on synovial membrane and cartilage by its IL-1β inhibitory effects. The aim of this review article is to discuss the role of diacerein in osteoarthritis and to explore the possible mechanism of action of diacerein in rheumatoid arthritis.
Type of Medium:
Online Resource
ISSN:
0974-360X
,
0974-3618
DOI:
10.52711/0974-360X.2022.00454
Language:
English
Publisher:
A and V Publications
Publication Date:
2022
detail.hit.zdb_id:
2846942-2
SSG:
15,3
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