ISSN:
1432-1912
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. The saluretic activity in rats and the carbonic anhydrase inhibitory activity (CAH) in vitro was compared in several aromatic sulphamyl compounds with free and alkylated sulphamyl groups. 2. Saluretic active disulphamylanilines showed a higher degree of CAH than saluretic inactive analogues. 3. No such correlation could be observed in dihydrobenzothiadiazines, which generally exert higher saluretic activity and smaller CAH in vitro than disulphamylanilines. There is however some correlation between the saluretic activity of dihydrobenzothiadiazines and the saluretic activity as well as the CAH in vitro of their corresponding disulphamylanilines, which can be formed by hydrolysis of the former. 4. The two compounds without substituent in the m-amino-position of the benzene nucleus do not fit into the scheme summarized in 2 and 3. 5. In compounds where the sulphamyl groups are alkylated (N-alkylation), no in vitro CAH can be expected. After peroral administration of saluretic active N-alkylated compounds, a CAH could be found in the urine, so that dealkylation can be assumed. CAH seems to be one of the conditions for saluretic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00244940
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