ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of the four possible optically active 2-dehydro-emetines is described and their absolute configuration established. Only one of these isomers, namely (-)-2-dehydro-emetine (IIIa) which has at the two asymmetric centres 11b and 1′ the same absolute configuration as the natural alkaloid (-)-emetine, shows in vitro and in vivo high amoebicidal activity.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19620450656
Permalink