In:
Journal of Applied Physiology, American Physiological Society, Vol. 16, No. 1 ( 1961-01-01), p. 1-7
Abstract:
In 379 mice subjected to from 1 to 11 atm. of pO 2 and 0 to 304 mm Hg of pCO 2 for 90 minutes, oxygen was convulsigenic at pressures greater than 3 atm. and lethal at greater than 4 atm. Carbon dioxide in 1 atm. of O 2 was not convulsigenic but was lethal at very high tensions. In the presence of O 2 at high pressure (OHP) small elevations of CO 2 tension shortened the preconvulsive latent period, whereas CO 2 tensions greater than 120 mm Hg inhibited convulsions. Survival time in OHP was shortened by the addition of CO 2 . An interaction between OHP and CO 2 effects is suggested by both the preconvulsive latent period and survival time data. The effects of CO 2 on OHP and electroshock convulsions are compared and possible reasons for differences are discussed in light of the previously demonstrated general cortical depression and inhibition of convulsions by CO2. The potentiation of OHP convulsions by low CO 2 tensions is probably due to effects on brain blood flow. Although death can occur without convulsions there is a tendency for animals susceptible to convulsions to be also susceptible to the lethal properties of OHP with CO 2 . Submitted on July 28, 1960
Type of Medium:
Online Resource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/jappl.1961.16.1.1
Language:
English
Publisher:
American Physiological Society
Publication Date:
1961
detail.hit.zdb_id:
1404365-8
SSG:
12
SSG:
31
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