In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 198, No. 2 ( 1960-02-01), p. 237-243
Abstract:
Arterial pH of anesthetized dogs was maintained constant for 90 minutes during continuous infusion of 0.15 m HCl or NaHCO 3 (0.3 cc/kg/min.) by adjusting alveolar ventilation with a respiration pump. This resulted in simultaneous metabolic acidosis and respiratory alkalosis (acid infusion) or metabolic alkalosis and respiratory acidosis (base infusion) equal in degree with respect to their effect on blood pH. Since urine pH dropped and renal acid excretion increased during metabolic acidosis and respiratory alkalosis, while pH rose and acid excretion decreased during metabolic alkalosis and respiratory acidosis, metabolic acid-base disturbances appear to exert more influence on renal acid excretion than do respiratory disturbances comparable in terms of their effect on pH. This difference in response was shown not to be due to a time lag in renal response to respiratory disturbances, nor could it be explained by effects on urine flow, renal hemodynamics or renal handling of sodium.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1960.198.2.237
Language:
English
Publisher:
American Physiological Society
Publication Date:
1960
detail.hit.zdb_id:
1477334-X
detail.hit.zdb_id:
2065807-2
detail.hit.zdb_id:
1477287-5
detail.hit.zdb_id:
1477308-9
detail.hit.zdb_id:
1477297-8
detail.hit.zdb_id:
1477331-4
detail.hit.zdb_id:
1477300-4
detail.hit.zdb_id:
1477329-6
SSG:
12
Permalink
