In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 206, No. 4 ( 1964-04-01), p. 750-754
Abstract:
Free water clearance (C H H2 O ) was studied in five normal subjects and in a patient with diabetes insipidus before and during the infusion of angiotensin II (Ciba), .2 µg/min. With angiotensin, C H H2 O fell markedly, with only small changes in urinary osmolality both in the normal subjects and in the patient with diabetes insipidus. The fall in C H H2 O was accompanied by a fall in U Na V, effective renal plasma flow (ERPF), and glomerular filtration rate (GFR). A physiological dose of Pitressin (25 mU/hr) given after the angiotensin, abolished C H H2 O and markedly increased urinary osmolality while U Na V, ERPF, and GFR returned toward normal. The results may be best explained as a direct effect of angiotensin on renal hemodynamics, to decrease filtered sodium and water. Reabsorption of an increased fraction of filtered sodium and water by the proximal tubule would limit the amount reaching the diluting segment of the nephron and excreted in the urine. A possible role for angiotensin in the impaired water excretion of certain disease states, such as Addison's disease and congestive heart failure was suggested.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1964.206.4.750
Language:
English
Publisher:
American Physiological Society
Publication Date:
1964
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12
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