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  • 1965-1969  (8)
  • 1
    Online Resource
    Online Resource
    Aberrant left pulmonary artery.
    BMJ ; 1968
    In:  Heart Vol. 30, No. 1 ( 1968-01-01), p. 110-114
    Details
    In: Heart, BMJ, Vol. 30, No. 1 ( 1968-01-01), p. 110-114
    Type of Medium: Online Resource
    ISSN: 1355-6037
    URL: Article
    DOI: 10.1136/hrt.30.1.110
    Language: English
    Publisher: BMJ
    Publication Date: 1968
    detail.hit.zdb_id: 1475501-4
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  • 2
    Online Resource
    Online Resource
    HYDROXYPROLINE IN HEALING DERMAL WOUNDS OF NORMAL AND HYPOTHYROID RATS
    Oxford University Press (OUP) ; 1967
    In:  Acta Endocrinologica Vol. 54, No. 1 ( 1967-01), p. 1-7
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 54, No. 1 ( 1967-01), p. 1-7
    Abstract: Various fractions of hydroxyproline were determined in surgical dermal wounds and in the intact skin of normal and hypothyroid rats. Hypothyroidism was induced by feeding the animals for five months with thiouracil containing diet (0.3%). Fourteen day old wounds and samples of intact skin were processed by the extractive chemical method used for the study of tissue collagen. Significant increase of a saline-extractable. and total soluble hydroxyproline, and reduction of insoluble fraction was found in the normal wound. This was considered due to the vigorous biosynthesis of collagen. Such a synthesis was previously found by histological methods in the wounds of the same age in rats. No evidence of the synthesis of new collagen was found in the wounds of hypothyroid rats in which saline-extractable and total soluble fractions of hydroxyproline did not significantly increase during the healing process. Insoluble fractions were higher in the wounds of hypothyroid rats than in normal control animals. It was concluded that biosynthesis, solubility, and overall metabolism of collagen in hypothyroid rats is deficient, under the conditions of this experiment.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0540001
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1967
    detail.hit.zdb_id: 1485160-X
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  • 3
    Online Resource
    Online Resource
    Studies on lipoic acid uptake by bacteria. III. Intracellular distribution of enzymes
    Canadian Science Publishing ; 1969
    In:  Canadian Journal of Microbiology Vol. 15, No. 2 ( 1969-02-01), p. 183-187
    Details
    In: Canadian Journal of Microbiology, Canadian Science Publishing, Vol. 15, No. 2 ( 1969-02-01), p. 183-187
    Abstract: Because the lipoic acid activating systems catalyze reactions which are formally expected for an energy-dependent transport system, an examination of their cellular distribution was made. The pyruvate: lipoate oxidoreductase (acceptor-acetylating) complex (E.C. No. 1.2.4.1) and the lipoic acid activating system in both S. faecalis 10 C1 and E. coli (Crookes strain) were found entirely in the membrane supernatant solution preparations (soluble enzymes). NADH oxidase was located in the solubilized membrane preparation, suggesting that the membrane preparations were representative, and glucose-6-phosphate dehydrogenase was found almost exclusively in the soluble fraction. It appears unlikely from distribution studies that the enzyme(s) of the lipoic acid activating system are involved in the transport of the lipoic acid into the cell.
    Type of Medium: Online Resource
    ISSN: 0008-4166 , 1480-3275
    URL: Article
    DOI: 10.1139/m69-030
    RVK:
    WA 15000
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1969
    detail.hit.zdb_id: 280534-0
    detail.hit.zdb_id: 1481972-7
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Steric effects in the solvolysis of cis- and trans-1,1-dichloro-2,3-dipropylcyclopropane
    American Chemical Society (ACS) ; 1968
    In:  The Journal of Organic Chemistry Vol. 33, No. 10 ( 1968-10), p. 3947-3948
    Details
    In: The Journal of Organic Chemistry, American Chemical Society (ACS), Vol. 33, No. 10 ( 1968-10), p. 3947-3948
    Type of Medium: Online Resource
    ISSN: 0022-3263 , 1520-6904
    URL: Article
    DOI: 10.1021/jo01274a060
    RVK:
    VA 5350
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 1968
    detail.hit.zdb_id: 1472273-2
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  • 5
    Online Resource
    Online Resource
    Umbilical-vein Exposure for Transfusion in Newborn
    BMJ ; 1965
    In:  BMJ Vol. 2, No. 5470 ( 1965-11-06), p. 1125-1125
    Details
    In: BMJ, BMJ, Vol. 2, No. 5470 ( 1965-11-06), p. 1125-1125
    Type of Medium: Online Resource
    ISSN: 0959-8138 , 1468-5833
    URL: Article
    DOI: 10.1136/bmj.2.5470.1125-b
    Language: English
    Publisher: BMJ
    Publication Date: 1965
    detail.hit.zdb_id: 1479799-9
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  • 6
    Online Resource
    Online Resource
    BONE AND URINARY HYDROXYPROLINE IN NORMAL AND HYPOTHYROID RAT WITH A LONG BONE FRACTURE
    Oxford University Press (OUP) ; 1967
    In:  Acta Endocrinologica Vol. 56, No. 3 ( 1967-11), p. 547-553
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 56, No. 3 ( 1967-11), p. 547-553
    Abstract: Urinary excretion of hydroxyproline, considered as an index of collagen metabolism, was determined prior to, and during, a period of fracture healing in normal and hypothyroid rats. Hypothyroidism was induced by feeding the animals for eight months with a diet containing thiouracil (0.3%). A closed complete fracture of the humerus was produced and left unsupported for 28 days. At the end of this healing period, hydroxyproline of fractured and intact humerus was also determined. Significant increase of a saline extractable and total hydroxyproline was found in fractured bone of the normal rat and this was considered due to the synthesis of new collagen. No evidence of such a change in saline extractable hydroxyproline was found in hypothyroid rats. Significant progressive decrease of urinary hydroxyproline was found in hypothyroid rats during the period of fracture healing. Under the conditions of this experiment, evidence of deficient collagen synthesis and metabolism in hypothyroid rats is confirmed.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0560547
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1967
    detail.hit.zdb_id: 1485160-X
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  • 7
    Online Resource
    Online Resource
    Effect of growth hormone, an anabolic steroid, and cortisone upon various fractions of skin and bone hydroxyproline in mice
    Canadian Science Publishing ; 1968
    In:  Canadian Journal of Physiology and Pharmacology Vol. 46, No. 4 ( 1968-07-01), p. 591-594
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 46, No. 4 ( 1968-07-01), p. 591-594
    Abstract: Various fractions of hydroxyproline were determined in skin, femora, and humeri of DBA/2 mice treated for 2 weeks with one of three hormones: bovine growth hormone, anabolic steroid (17-β-hydroxy-17-α-methylandrostano[3,2-c]pyrazole), and cortisone acetate. The following fractions were studied: 0.15 M NaCl, 0.50 M NaCl, 0.50 M citrate, and total hydroxyproline. Since collagen is the only protein in the body containing hydroxyproline in significant amounts, this fractionation method allows an appraisal of the rates of synthesis, maturation, and breakdown of collagen. Growth hormone produced a significant increase in all extractable fractions and in the total hydroxyproline content of tissues studied. The action of anabolic steroid on hydroxyproline was generally comparable to that of growth hormone, but was less marked. Both total hydroxyproline and saline-extractable fractions were significantly reduced in skin and bone of cortisone-treated mice.
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/y68-086
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1968
    detail.hit.zdb_id: 2004356-9
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  • 8
    Online Resource
    Online Resource
    EFFECT OF GROWTH HORMONE AND AN ANABOLIC STEROID ON HYDROXYPROLINE IN HEALING DERMAL WOUNDS IN RATS
    Oxford University Press (OUP) ; 1968
    In:  Acta Endocrinologica Vol. 59, No. 1 ( 1968-09), p. 53-66
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 59, No. 1 ( 1968-09), p. 53-66
    Abstract: Various fractions of hydroxyproline were determined in intact skin and in surgical dermal wounds of rats treated or not with one of two hormones: bovine growth hormone and anabolic steroid methandrostenolone. Serum hydroxyproline was also studied in these rats. Sampling was done prior to surgery, and at the end of the first and third weeks following operation. It was assumed that with the methods used, some information may be obtained regarding the synthesis and breakdown of collagen at early stage of wound healing. Presence of dermal wound was associated with significant increase of saline-extractable and total hydroxyproline in the skin distant from the healing wound. These fractions were also elevated in the scars. Growth hormone produced a significant increase in all extractable fractions and total hydroxyproline of both skin and scar. Serum hydroxyproline was also elevated in rats treated with growth hormone. These changes were considered due to the action of growth hormone on both synthesis and breakdown of collagen. The action of anabolic steroid on tissue hydroxyproline was generally comparable to that of growth hormone, but was much less marked. Methandrostenolone did not affect serum hydroxyproline content under the conditions of this experiment.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.0590053
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1968
    detail.hit.zdb_id: 1485160-X
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