In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 51, No. 3 ( 1966-03), p. 369-376
Abstract:
The 'subcellular' localization of radioiodine was observed in the thyroid follicles of rats following the injection (i.p.) of 75 μc to 1000 μc of radioiodide ( 125 I). Twenty-four hours after the injection of the smaller doses (75, 150 and 250 μc), the radioiodine was distributed evenly throughout the follicular lumen. Twenty-four hours after the injection of the large dose (1 mc) of radioiodide, there were two histological patterns of follicular radioiodine localization. In the majority of follicles (about 85%) the radioiodine was distributed uniformly throughout the lumen. In the other follicles (15%) the activity was not uniformly distributed but was primarily localized along the cell-colloid border. At this interface, the radioactivity was entirely localized in the colloidal region. A possible explanation is that the follicles with an intra-colloidal ring of radioiodine are more sensitive to the early effects of radiation and could be reflecting some cellular biochemical alteration.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0510369
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1966
detail.hit.zdb_id:
1485160-X
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