ISSN:
0001-1541
Keywords:
Chemistry
;
Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The horizontal rotating cylinder blood oxygenator has been developed to minimize shear, eliminate bubbles, reduce holdup, and provide for rapid change of the controlled temperature of the blood.To aid in the development of this apparatus a detailed mathematical model was formulated. A simplified model was also developed which yielded an analytical expression relating the amount of material transferred between the gas and liquid in the apparatus to operating variables. In developing these models an attempt was made to include a realistic mechanism for oxygen absorption in blood.Preliminary experiments were carried out by absorbing carbon dioxide into distilled water in the horizontal rotating cylinder. These preliminary results were found to be in good agreement with previous theoretical predictions and calculations that indicated that the equipment should be adequate to act as a lung substitute for a dog. When it was employed in this manner during open-heart surgery, insufficient oxygen was transferred to support the dog.It is concluded that the most probable reason for failure of the horizontal cylinder to act satisfactorily as a blood oxygenator is poor mixing in the blood pool.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aic.690120123
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