ISSN:
1432-2072
Keywords:
Imipramine Metabolism
;
Desmethylimipramine
;
Routes of Administration
;
Route of Absorption
;
Intraperitoneal
;
Color tracing
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Rats were given i.p. injections of imipramine by two different techniques. In each animal the site of injection was localized by a new color tracing method. Unintentionally, one of the techniques resulted in an intramuscular application instead of an i.p. injection, in this case, no desmethylimipramine was detectable in the brain. The other technique gave a true i.p. injection which resulted in the appearance of desmethylimipramine in the brain. These findings probably explain the discrepancies of reported data on the appearance of desmethylimipramine in the brain after imipramine administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00403618
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