ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
24-Hydroxycholesterol (cerebrosterol, cholest-5-ene-3β;, 24ξ-diol) occurs at low levels in human (Di Frisco, De Ruggieri and Ercoli, 1953; Ercoli and De Ruggieri, 1953a, 19536; Schubert, Rose and Burger, 1961; Van Lier and Smith, 1969, 1970), equine (Ercoli, Di Frisco and De Ruggieri, 1953a; Ercoli and De Ruggieri, 1953a, 1953b; Fieser, Huang and Bhattacharyya, 1957) and bovine (Richter and Dannenberg, 1969) brain tissue. Only one of two possible C-24 epimeric alcohols appears to occur in human brain (Van Lier and Smith, 1970) and the sterol may be regarded as a true endogenous trace-level sterol and not as an artifact of autoxidation derived during isolation and analysis. As a phase of our continuing interests in the presence of trace-level polar sterols in human tissues (Van Lier and Smith, 1967, 1969, 1970, 1971a; Smith and Van Lier, 1970), we sought to measure levels of 24-hydroxycholesterol in different parts of human brain by gas chromatographic means. The present report deals with our measurements of 24-hydroxycholesterol in human cortex, subcortical white matter, midbrain, pons, and cerebellum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1972.tb01406.x
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