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  • 1
    Electronic Resource
    Electronic Resource
    MICROASSAY OF ADENOSINE-3′,5′-MONOPHOSPHATE (CYCLIC AMP) IN BRAIN AND OTHER TISSUES BY THE LUCIFERIN-LUCIFERASE SYSTEM (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— A simple, sensitive and specific method for assaying cyclic AMP in various tissues is reported. Cyclic AMP was isolated from contaminating nucleotides and was converted to ATP with a phosphodiesterase-myokinase-pyruvate kinase system. The ATP was determined enzymically in a liquid scintillation counter by the firefly luciferin-luciferase technique. This procedure was capable of detecting as little as 5 × 10−14 mol of cyclic AMP and could therefore be used for analyses on less than 1 mg of brain. The assay was reproducible and linear over a wide range of tissue concentrations.In the rat, the highest levels of cyclic AMP (2.7–4.2 pmol/mg wet wt. of tissue) were present in the pineal, heart, pituitary, thyroid, cerebellar cortex, kidney, adrenal, liver and pyloric region of the stomach; intermediate levels (1.5–2.7 pmol/mg wet wt. of tissue) were found in testis, skin, aorta, intestine, submaxillary gland, spleen, muscle and cerebral cortex, moderately low levels (1.0–1.5 pmol/mg wet wt. of tissue) were found in lung, trachea and greater curvature of the stomach; whereas low levels (0.15–0.60 pmol/mg wet wt. of tissue) were found in adipose tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb00556.x
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  • 2
    Electronic Resource
    Electronic Resource
    PROTEIN METABOLISM AND AMINO ACID ACCUMULATION IN THE RAT SUBMAXILLARY GLAND DURING REDUCED SYMPATHETIC ACTIVITY (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Unilateral sympathetic decentralization of the superior cervical ganglion of rats was performed 3 days prior to the experiments. A two-compartment kinetic model was proposed to describe the effect of decentralization on (1) the uptake of a nonphysiological amino acid from plasma to the submaxillary gland and (2) the incorporation of a physiological amino acid from precursor pool into protein. The calculations based on the model showed that the fractional rate constant for efflux of the nonphysiological amino acid, α-[3-14C] aminoisobutyric acid, was greater in the decentralized than in the normal gland. However, efflux rate was equal in the two glands because the extrapolated zero time value of the initial concentration was greater in the normal gland.The labelled physiological amino acid, [14C]leucine, was used in initial experiments to assess turnover rate of the gland proteins but it was rapidly metabolized to many other radioactive compounds. Therefore, arginine[14C]guanido was employed-arginine being the only labelled amino acid found after injection. Since the steady state content of submaxillary gland proteins was not changed but the fractional rate constant of conversion of free arginine into protein (kp) was greater in the decentralized gland (kp= 0-40 h_l) than in the normal (kp= 0-27 h−1), we can conclude that decentralization increases protein turnover rate; thus, assuming that arginine[14C]guanido is homogeneously distributed in the tissue pools of free arginine, the rate of protein turnover is greater in the sympathetically decentralized gland than in the normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb12011.x
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  • 3
    Electronic Resource
    Electronic Resource
    Assay by multiple ion detection of phenylethylamine and phenylethanolamine in rat brain (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04413.x
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  • 4
    Electronic Resource
    Electronic Resource
    Regulation of Biosynthesis of Catecholamines and Serotonin in the CNS (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 491-491 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.002423
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  • 5
    Electronic Resource
    Electronic Resource
    THE PHARMACOLOGICAL IMPLICATIONS OF Δ9-TETRAHYDROCANNABINOL METABOLISM BY LUNG: EFFECTS OF 3-METHYLCHOLANTHRENE (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 191 (1971), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1971.tb14000.x
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  • 6
    Electronic Resource
    Electronic Resource
    DISCUSSION (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 185 (1971), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1971.tb45280.x
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  • 7
    Electronic Resource
    Electronic Resource
    Metabolism of Δ 9 -Tetrahydrocannabinol by Lung and Liver Homogenates of Rats treated with Methylcholanthrene (1971)
    [s.l.] : Nature Publishing Group
    Nature 234 (1971), S. 48-49 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Young male Sprague-Dawley rats (Zivic Miller, Pittsburgh, 50-60 g) were injected intraperitoneally with 3-methylcholanthrene (20 mg/kg) in 0.25 ml. of sesame oil daily for 4 days. Control rats were given injections of sesame oil. Each group consisted of three rats, fed liberally with Purina chow. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/234048a0
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  • 8
    Electronic Resource
    Electronic Resource
    Involvement of brain cholinergic mechanisms in the action of chlorpromazine (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 664-666 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chlorpromazine and haloperidol, neuroleptics which increase the turnover rate of DA in striatum6'7, presumably block DA receptor function8. Such an action has been credited as an explanation for the antagonism by chlorpromazine of certain behavioural effects induced by amphetamine9. It is pertinent ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249664a0
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  • 9
    Electronic Resource
    Electronic Resource
    Mechanisms involved in the trans-synaptic increase of tyrosine hydroxylase and dopamine-β-hydroxylase activity in sympathetic ganglia (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 280 (1973), S. 39-48 
    Details
    ISSN: 1432-1912
    Keywords: Superior Cervical Ganglion ; Cold Exposure ; Tyrosine Hydroxylase ; Decentralization ; Mecamylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exposure at 4°C for 4 h increases the activity of tyrosine hydroxylase (TH) and dopamine-β-hydroxylase in superior cervical ganglia of bilateral adrenal demedullated (three weeks before) rats, but not that of normal rats. One or two weeks after adrenal demedullation, TH and DBH activities failed to be increased after exposure to 4°C for 4 h. Pretreatment with a nicotinic receptor antagonist (mecamylamine 15 μmoles/kg i.p.) abolishes the induction of TH but several injections of this drug beginning either after termination of cold exposure or 24 h later fail to inhibit TH induction. Decentralization performed at the end of cold exposure, 17 or 24 h later abolishes TH and DBH induction elicited by cold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505353
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  • 10
    Electronic Resource
    Electronic Resource
    Involvement of 3′,5′-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 278 (1973), S. 195-206 
    Details
    ISSN: 1432-1912
    Keywords: cAMP ; Tyrosine Hydroxylase ; Adrenal Medulla ; Cold Exposure ; Catecholamine Turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the relationship between changes of 3′,5′-cyclic adenosine monophosphate (cAMP) and tyrosine hydroxylase (TH) activity in adrenal medulla of rats exposed to cold stress. Exposure of rats to 4° C produced a ten-fold increase of the cAMP content of adrenal medulla in about 30 min. This increase persisted for about one hour; the levels of cAMP returned to control value within 120 min in spite of the continued exposure to 4° C. In rats with monolaterally denervated (splanchnicotomized) adrenal, the exposure to 4° C produced only insignificant changes of cAMP concentration. During the exposure to 4° C we also observed an increase (about two times) of catecholamine turnover rate as measured by 3H-dopamine efflux from adrenal glands. This increased efflux persisted for 6 h of exposure to cold suggesting that the efflux of 3H-dopamine can increase without a simultaneous increase of cAMP concentrations. Exposure of rats to 4° C for two hour also increases (about two times) the TH activity as measured 24 h later. Exposure of the animals to 4° C for a time period longer than two hour (4 or 24 h) failed to produce further increases of TH activity. These results support the concept that the increase of cAMP concentrations in adrenal medulla may play a central role in initiating the chain of biochemical events modulating the synthesis of TH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500650
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