ISSN:
1471-0528
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Endocervical columnar epithelium with stroma intact, was maintained in organ culture for up to ten days. Many explants showed a progressive dedifferentiation, pyknosis and eventual loss of columnar cells with a gradual replacement of these with metaplastic cells apparently of stromal origin. This was a progression of changes similar to squamous metaplasia seen in vivo. Studies of the surface characteristics of the cultured tissue, with the scanning electron microscope, showed a change of cell type from columnar cells with closely packed micro-villi, to a flattened squamous type with interdigitating cell boundaries and a mixed surface structure of micro-ridges and micro-villi.The significance of these results and the use of this organ culture system as a model in the study of the actiology of cervical malignancy is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-0528.1973.tb02175.x
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