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  • 1
    Online Resource
    Online Resource
    Supporting Information
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 4 ( 1970-01-01), p. 401-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 4 ( 1970-01-01), p. 401-
    Abstract: Recently, three-dimensional (3D) bioprinting technology is becoming an appealing approach for osteochondral repair. However, it is challenging to develop a bilayered scaffold with anisotropic structural properties to mimic a native osteochondral tissue. Herein, we developed a bioink consisting of decellularized extracellular matrix and silk fibroin to print the bilayered scaffold. The bilayered scaffold mimics the natural osteochondral tissue by controlling the composition, mechanical properties, and growth factor release in each layer of the scaffold. The in vitro results show that each layer of scaffolds had a suitable mechanical strength and degradation rate. Furthermore, the scaffolds encapsulating transforming growth factor-beta (TGF- & beta;) and bone morphogenetic protein-2 (BMP-2) can act as a controlled release system and promote directed differentiation of bone marrow-derived mesenchymal stem cells. Furthermore, the in vivo experiments suggested that the scaffolds loaded with growth factors promoted osteochondral regeneration in the rabbit knee joint model. Consequently, the biomimetic bilayered scaffold loaded with TGF- & beta; and BMP-2 would be a promising strategy for osteochondral repair.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.18063/ijb.v7i4.401
    DOI: 10.18063/ijb.v7i4.401.s177
    DOI: 10.18063/ijb.v7i4.401.s178
    DOI: 10.18063/ijb.v7i4.401.s179
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Significance of EGFRGene Mutation in Fresh Cytological Specimens of Lung Adenocarcinoma
    Bio-Byword Scientific Publishing, Pty. Ltd. ; 1970
    In:  Proceedings of Anticancer Research Vol. 2, No. 2 ( 1970-01-01)
    Details
    In: Proceedings of Anticancer Research, Bio-Byword Scientific Publishing, Pty. Ltd., Vol. 2, No. 2 ( 1970-01-01)
    Abstract: Objective:This paper aims to study the mutation of epidermal growth factor receptor (EGFR) gene in fresh cytological specimens from patients with lung adenocarcinoma, and to determine the prognosis of positive patients by tyrosine kinase inhibitor (TKI). Methods: A total of 313 specimens from needle aspiration and pleural effusion were collected in the Cancer Detection Center of the Fourth Hospital of Hebei Medical University. After HE and immunocytochemistry stainings, the specimens were diagnosed as lung adenocarcinoma by two cytology pathologists. Themutation of 18-21 exon was detectied using ARMS to observe mutations situation. Then, the objective response rate (ORR) and the progression-free survival (PFS) between the targeted group and the chemotherapy group of patients were comparedith. Results: Among 313 cases, 293 cases of lung adenocarcinoma were diagnosed, and DNA specimens were extracted from 288 cases. The success rate was about 98.3%. 130 mutations were found and the rate was 45.1%. EGFR mutation of adenocarcinoma patients mainly occurred to females, nonsmokers, but had nothing to do with age. The ORR was statistically different between the targeted group with chemotherapy (P 〈 0.01), and PFS curve of targeted group was on chemotherapy group. The efficacy and the survival time of targeted group and targeted and chemotherapy group were superior to that of chemotherapy group. The results of the EGFR mutation and the prognosis of the tested positive patients in the fresh cytology samples were consistent with that from previous literatures. Conclusion: The results of the testwere accurate, and fresh cytological specimens can be used as a replacement for tumor tissue specimens.
    Type of Medium: Online Resource
    ISSN: 2208-3553 , 2208-3545
    URL: Issue
    URL: Article
    DOI: 10.26689/par.v2i2
    DOI: 10.26689/par.v2i2.362
    Language: Unknown
    Publisher: Bio-Byword Scientific Publishing, Pty. Ltd.
    Publication Date: 1970
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  • 3
    Online Resource
    Online Resource
    Fabrication and Biomedical Applications of Heart-on-a-chip
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 3 ( 1970-01-01), p. 370-
    Details
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 3 ( 1970-01-01), p. 370-
    Abstract: Heart diseases have become the main killer threatening human health, and various methods have been developed to study heart disease. Among them, heart-on-a-chip has emerged in recent years as a method for constructing disease (or normal) models in vitro and is considered as a promising tool to study heart diseases. Compared with other methods, the advantages of heart-on-a-chip include the high portability, high throughput, and the capability to mimic microenvironments in vivo. It has shown a great potential in disease mechanism study and drug screening. In this paper, we review the recent advances in hearton-a-chip, including the fabrication methods (e.g., 3D bioprinting) and biomedical applications. By analyzing the structure of the existing heart-on-a-chip, we proposed that a highly integrated heart-on-a-chip includes four elements: Microfluidic chips, cells/microtissues, microactuators to construct the microenvironment, and microsensors for results readout. Finally, the current challenges and future directions of heart-on-a-chip are discussed.
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    URL: Article
    DOI: 10.18063/ijb.v7i3.370
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
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  • 4
    Online Resource
    Online Resource
    Role of Clusterin in the Female Reproductive System
    Nepal Journals Online (JOL) ; 1970
    In:  Nepal Journal of Obstetrics and Gynaecology Vol. 5, No. 2 ( 1970-01-01), p. 3-7
    Details
    In: Nepal Journal of Obstetrics and Gynaecology, Nepal Journals Online (JOL), Vol. 5, No. 2 ( 1970-01-01), p. 3-7
    Abstract: DOI: http://dx.doi.org/10.3126/njog.v5i2.5069 NJOG 2010 Nov-Dec; 5(2): 3-7
    Type of Medium: Online Resource
    ISSN: 1999-8546 , 1999-9623
    URL: Article
    DOI: 10.3126/njog.v5i2.5069
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 1970
    detail.hit.zdb_id: 2430134-6
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